| Entry |
|
|---|
| Name |
Quinidine gluconate (USP);
Quinaglute (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C20H24N2O2. C6H12O7
|
|---|
| Exact mass |
520.2421
|
|---|
| Mol weight |
520.572
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
|
|---|
| Remark |
| Product (DG00192): | D00642<US> D02272<JP/US> |
|
|---|
| Efficacy |
Antiarrhythmic, Sodium channel blocker |
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTIARRHYTHMICS, CLASS I AND III
C01BA Antiarrhythmics, class Ia
C01BA01 Quinidine
D00642 Quinidine gluconate (USP) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Antiarrhythmics
Vaughn Williams-Class I
Quinidine
D00642 Quinidine gluconate (USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG00192 Quinidine
D00642 Quinidine gluconate
Drug classes [BR:br08332]
Cardiovascular agent
DG01653 Antiarrhythmics
D00642 Quinidine gluconate
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D00642 Quinidine gluconate (USP) <US>
SCN2A
D00642 Quinidine gluconate (USP) <US>
SCN3A
D00642 Quinidine gluconate (USP) <US>
SCN4A
D00642 Quinidine gluconate (USP) <US>
SCN5A
D00642 Quinidine gluconate (USP) <US>
SCN8A
D00642 Quinidine gluconate (USP) <US>
SCN9A
D00642 Quinidine gluconate (USP) <US>
SCN10A
D00642 Quinidine gluconate (USP) <US>
SCN11A
D00642 Quinidine gluconate (USP) <US>
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00642
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG00192 Quinidine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 37
1 C8y C 17.1259 -25.8770
2 C8y C 18.3511 -25.1828
3 C8y C 17.1200 -27.2832
4 C8x C 15.9240 -25.1769
5 C1c C 18.3568 -23.7825
6 C8x C 19.5645 -25.8887
7 C8x C 15.9240 -27.9891
8 N5x N 18.3394 -27.9948
9 C8y C 14.7046 -25.8770
10 C1y C 19.5762 -23.0824
11 O1a O 17.1374 -23.0707
12 C8x C 19.5588 -27.2949
13 C8x C 14.7046 -27.2832
14 O2a O 13.4911 -25.1769
15 N1y N 21.0115 -22.2073
16 C1x C 18.8470 -22.0381
17 C1a C 13.4911 -23.7766
18 C1x C 21.0115 -20.9704
19 C1x C 22.5109 -23.0124
20 C1y C 20.2589 -21.2038
21 C1y C 20.2647 -20.2178
22 C1x C 21.8167 -21.9038
23 C2b C 19.7280 -18.9109
24 C2a C 20.5914 -17.8024
25 C1c C 28.2753 -26.6350
26 C1c C 27.0735 -25.9406
27 C1c C 29.4887 -25.9406
28 O1a O 28.2753 -28.0410
29 C1c C 25.8598 -26.6350
30 O1a O 27.0735 -24.5346
31 C6a C 30.7024 -26.6350
32 O1a O 29.4887 -24.5346
33 C1b C 24.6464 -25.9406
34 O1a O 25.8598 -28.0410
35 O6a O 31.9158 -25.9406
36 O6a O 30.7024 -28.0410
37 O1a O 23.4327 -26.6350
BOND 39
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 2
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 5 11 1 #Down
11 6 12 1
12 7 13 1
13 9 14 1
14 10 15 1
15 10 16 1
16 14 17 1
17 15 18 1
18 15 19 1
19 16 20 1
20 18 21 1
21 19 22 1
22 21 23 1 #Up
23 23 24 2
24 8 12 2
25 9 13 2
26 20 21 1
27 20 22 1
28 25 26 1
29 25 27 1
30 25 28 1 #Up
31 26 29 1
32 26 30 1 #Up
33 27 31 1
34 27 32 1 #Up
35 29 33 1
36 29 34 1 #Down
37 31 35 1
38 31 36 2
39 33 37 1
|
|---|
