KEGG   DRUG: Brinzolamide
Entry
D00652                      Drug                                   
Name
Brinzolamide (JAN/USP/INN);
Azopt (TN)
Product
  Generic
Formula
C12H21N3O5S3
Exact mass
383.0643
Mol weight
383.5072
Structure
Simcomp
Class
Cardiovascular agent
 DG01534  Carbonic anhydrase inhibitor
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Remark
Same as: C07760
Therapeutic category: 1319
ATC code: S01EC04
Product: D00652<JP/US>
Product (mixture): D10512<JP> D10854<JP/US>
Efficacy
Antiglaucoma, Carbonic anhydrase inhibitor
  Disease
Open-angle glaucoma [DS:H00612]
Target
CA2 [HSA:760] [KO:K18245]
  Pathway
hsa04964  Proximal tubule bicarbonate reclamation
Interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EC Carbonic anhydrase inhibitors
     S01EC04 Brinzolamide
      D00652  Brinzolamide (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Carbonic Anhydrase Inhibitors, Ophthalmic
    Brinzolamide
     D00652  Brinzolamide (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00652  Brinzolamide (JAN/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01534  Carbonic anhydrase inhibitor
   D00652  Brinzolamide
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D00652  Brinzolamide
Drug classes [BR:br08332]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D00652  Brinzolamide
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Aldehyde-lyases
    CA2
     D00652  Brinzolamide (JAN/USP/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00652
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00652
Other DBs
CAS: 138890-62-7
PubChem: 7847718
ChEBI: 3176
PDB-CCD: BZ1[PDBj]
LigandBox: D00652
NIKKAJI: J1.143.859H
KCF data

ATOM        23
            1   C8y C    22.7083  -13.1828
            2   C8y C    22.7024  -14.5595
            3   S2x S    23.8982  -12.5004
            4   S2x S    21.3899  -12.7628
            5   C1y C    23.8982  -15.2479
            6   C8x C    21.3957  -14.9854
            7   N1y N    25.0825  -13.1828
            8   O3c O    22.6383  -11.5902
            9   O3c O    25.0067  -11.6602
            10  C8y C    20.5849  -13.8828
            11  C1x C    25.0825  -14.5595
            12  N1b N    23.8982  -16.6246
            13  C1b C    26.2784  -12.5004
            14  S4a S    19.2140  -13.8828
            15  C1b C    25.0884  -17.3073
            16  C1b C    27.4919  -13.2062
            17  N1a N    19.1614  -15.4812
            18  O3c O    19.1614  -12.5004
            19  O3c O    17.7730  -13.8887
            20  C1a C    25.0942  -18.6839
            21  C1b C    28.7052  -12.5004
            22  O2a O    29.9185  -13.2062
            23  C1a C    31.1261  -12.5004
BOND        24
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     3   9 2
            9     4  10 1
            10    5  11 1
            11    5  12 1 #Down
            12    7  13 1
            13   10  14 1
            14   12  15 1
            15   13  16 1
            16   14  17 1
            17   14  18 2
            18   14  19 2
            19   15  20 1
            20   16  21 1
            21   21  22 1
            22   22  23 1
            23    6  10 2
            24    7  11 1

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