| Entry |
|
|---|
| Name |
Dorzolamide hydrochloride (JP18/USP);
Trusopt (TN) |
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| Product |
|
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| Generic |
DORZOLAMIDE HCL (Bausch & Lomb Incorporated), DORZOLAMIDE HYDROCHLORIDE (Alembic Pharmaceuticals), DORZOLAMIDE HYDROCHLORIDE (Biocon Pharma), DORZOLAMIDE HYDROCHLORIDE (FOSUN PHARMA USA), DORZOLAMIDE HYDROCHLORIDE (Gland Pharma Limited), DORZOLAMIDE HYDROCHLORIDE (Golden State Medical Supply), DORZOLAMIDE HYDROCHLORIDE (Indoco Remedies Limited), DORZOLAMIDE HYDROCHLORIDE (Leading Pharma), DORZOLAMIDE HYDROCHLORIDE (Sandoz), DORZOLAMIDE HYDROCHLORIDE OPHTHALMIC (A-S Medication Solutions), DORZOLAMIDE HYDROCHLORIDE OPHTHALMIC SOLUTION (Micro Labs Limited) |
|---|
| Formula |
C10H16N2O4S3. HCl
|
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| Exact mass |
360.0039
|
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| Mol weight |
360.901
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01534 Carbonic anhydrase inhibitor
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01639 CYP2C19 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 1319 |
| Product (DG01135): | D00653<JP/US> |
| Product (mixture): | D08493<JP/US> |
|
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| Efficacy |
Antiglaucoma, Carbonic anhydrase inhibitor |
|---|
| Disease |
Open-angle glaucoma [DS: H00612] |
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| Comment |
Diuretic aciton
|
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| Target |
|
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| Pathway |
| hsa04964 | Proximal tubule bicarbonate reclamation |
|
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559], CYP2C19 [HSA: 1557], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
| map07055 | Sulfonamide derivatives - overview |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EC Carbonic anhydrase inhibitors
S01EC03 Dorzolamide
D00653 Dorzolamide hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Ophthalmic Agents
Intraocular Pressure Lowering Agents
Carbonic Anhydrase Inhibitors, Ophthalmic
Dorzolamide
D00653 Dorzolamide hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D00653 Dorzolamide hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01534 Carbonic anhydrase inhibitor
DG01135 Dorzolamide
D00653 Dorzolamide hydrochloride
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01135 Dorzolamide
D00653 Dorzolamide hydrochloride
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01135 Dorzolamide
D00653 Dorzolamide hydrochloride
DG01639 CYP2C19 substrate
DG01135 Dorzolamide
D00653 Dorzolamide hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01135 Dorzolamide
D00653 Dorzolamide hydrochloride
Drug classes [BR:br08332]
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D00653 Dorzolamide hydrochloride
Target-based classification of drugs [BR:br08310]
Enzymes
Lyases (EC4)
Aldehyde-lyases
CA
D00653 Dorzolamide hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00653 Dorzolamide hydrochloride
D00653 Dorzolamide hydrochloride ophthalmic solution
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00653
Drug groups [BR:br08330]
Cardiovascular agent
DG01534 Carbonic anhydrase inhibitor
DG01135 Dorzolamide
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01135 Dorzolamide
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01135 Dorzolamide
DG01639 CYP2C19 substrate
DG01135 Dorzolamide
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01135 Dorzolamide
|
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| Other DBs |
|
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| KCF data |
ATOM 20
1 C8y C 19.3200 -14.9100
2 C8y C 19.3200 -16.3100
3 S2x S 20.5100 -14.2800
4 S2x S 17.9900 -14.4900
5 C1y C 20.5100 -17.0100
6 C8x C 17.9900 -16.7300
7 C1y C 21.7000 -14.9100
8 O3c O 19.2500 -13.3700
9 O3c O 21.6300 -13.4400
10 C8y C 17.2200 -15.6100
11 C1x C 21.7000 -16.3100
12 N1b N 20.5100 -18.4100
13 C1a C 22.8900 -14.2800
14 S4a S 15.8200 -15.6100
15 C1b C 21.7000 -19.0400
16 N1a N 15.8200 -17.2200
17 O3c O 15.8200 -14.2800
18 O3c O 14.3500 -15.6100
19 C1a C 21.7314 -20.4396
20 X Cl 23.7300 -17.6400
BOND 20
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 2
8 3 9 2
9 4 10 1
10 5 11 1
11 5 12 1 #Down
12 7 13 1 #Up
13 10 14 1
14 12 15 1
15 14 16 1
16 14 17 2
17 14 18 2
18 6 10 2
19 7 11 1
20 15 19 1
|
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