KEGG   DRUG: Trichlormethiazide
Entry
D00658                      Drug                                   
Name
Trichlormethiazide (JP18/USP/INN);
Naqua (TN)
Formula
C8H8Cl3N3O4S2
Exact mass
378.9022
Mol weight
380.6558
Structure
Simcomp
Class
Cardiovascular agent
 DG03231  Antihypertensive
  DG01749  Thiazide diuretic
 DG01690  Sulfonamide diuretic
  DG01749  Thiazide diuretic
Remark
Same as: C07767
Therapeutic category: 2132
ATC code: C03AA06
Product: D00658<JP>
Product (mixture): D10480<JP>
Efficacy
Antihypertensive, Diuretic, Na+-Cl- symport inhibitor
Comment
Thiazides
Target
SLC12A3 (TSC) [HSA:6559] [KO:K14426]
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425]
Interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03A LOW-CEILING DIURETICS, THIAZIDES
    C03AA Thiazides, plain
     C03AA06 Trichlormethiazide
      D00658  Trichlormethiazide (JP18/USP/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2132  Thiazides
     D00658  Trichlormethiazide (JP18/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG01749  Thiazide diuretic
    D00658  Trichlormethiazide
  DG01690  Sulfonamide diuretic
   DG01749  Thiazide diuretic
    D00658  Trichlormethiazide
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D00658  Trichlormethiazide
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1 (NKCC2)
     D00658  Trichlormethiazide (JP18/USP/INN) <JP>
    SLC12A3 (TSC)
     D00658  Trichlormethiazide (JP18/USP/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00658  Trichlormethiazide
  D00658  Trichlormethiazide tablets
Other DBs
CAS: 133-67-5
PubChem: 7847724
ChEBI: 9683
LigandBox: D00658
NIKKAJI: J2.527E
KCF data

ATOM        20
            1   C8y C    24.9600  -17.0201
            2   C8y C    25.0243  -18.4245
            3   C8x C    26.1773  -16.3296
            4   S2x S    23.7547  -16.3238
            5   N1x N    23.7547  -19.1210
            6   C8x C    26.1656  -19.1267
            7   C8y C    27.3827  -17.0318
            8   N1x N    22.5374  -17.0201
            9   O3c O    22.5316  -15.6216
            10  O3c O    24.9543  -15.6158
            11  C1y C    22.5374  -18.4245
            12  C8y C    27.3769  -18.4305
            13  S4a S    28.5823  -16.3296
            14  C1c C    21.3203  -19.1210
            15  X   Cl   28.5765  -19.1267
            16  N1a N    29.7936  -15.4811
            17  O3c O    27.5933  -15.3290
            18  O3c O    29.6356  -17.1781
            19  X   Cl   20.1090  -18.4245
            20  X   Cl   21.3844  -20.5195
BOND        21
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     4   9 2
            9     4  10 2
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13   11  14 1
            14   12  15 1
            15   13  16 1
            16   13  17 2
            17   13  18 2
            18   14  19 1
            19   14  20 1
            20    7  12 1
            21    8  11 1

» Japanese version   » Back

DBGET integrated database retrieval system