 | | DRUG: Azelastine hydrochloride | |
| Entry |
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| Name |
Azelastine hydrochloride (JP18/USP);
Astelin (TN) |
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| Product |
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| Generic |
AZELASTINE (Ascend Laboratories), AZELASTINE HCL NASAL (Bryant Ranch Prepack), AZELASTINE HCL NASAL (Padagis Israel Pharmaceuticals), AZELASTINE HYDROCHLORIDE (A-S Medication Solutions), AZELASTINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), AZELASTINE HYDROCHLORIDE (Apotex Corp.), AZELASTINE HYDROCHLORIDE (Apotex Corp.), AZELASTINE HYDROCHLORIDE (Aurobindo Pharma Limited), AZELASTINE HYDROCHLORIDE (Aurobindo Pharma Limited), AZELASTINE HYDROCHLORIDE (AvKARE), AZELASTINE HYDROCHLORIDE (Breckenridge Pharmaceutical), AZELASTINE HYDROCHLORIDE (Bryant Ranch Prepack), AZELASTINE HYDROCHLORIDE (Fosun Pharma USA), AZELASTINE HYDROCHLORIDE (Gland Pharma Limited), AZELASTINE HYDROCHLORIDE (Preferred Pharmaceuticals), AZELASTINE HYDROCHLORIDE (Proficient Rx LP), AZELASTINE HYDROCHLORIDE (RPK Pharmaceuticals), AZELASTINE HYDROCHLORIDE (RPK Pharmaceuticals), AZELASTINE HYDROCHLORIDE (RPK Pharmaceuticals), AZELASTINE HYDROCHLORIDE (Sandoz), AZELASTINE HYDROCHLORIDE (Somerset Therapeutics), AZELASTINE HYDROCHLORIDE (Sun Pharmaceutical Industries), AZELASTINE HYDROCHLORIDE (Sun Pharmaceutical Industries), AZELASTINE HYDROCHLORIDE (Zydus Lifesciences Limited), AZELASTINE HYDROCHLORIDE (Zydus Pharmaceuticals USA), AZELASTINE HYDROCHLORIDE OPHTHALMIC SOLUTION 0.05% (Alembic Pharmaceuticals) |
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| Formula |
C22H24ClN3O. HCl
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| Exact mass |
417.1375
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| Mol weight |
418.3594
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| Structure |
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| Simcomp |
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Dermatological agent
DG03243 Atopic dermatitis agent
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| Remark |
| Therapeutic category: | 4490 |
| Product (DG01036): | D00659<JP/US> |
| Product (mixture): | D11656<US> |
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| Efficacy |
Antiallergic, Antiasthmatic, H1 receptor antagonist |
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| Disease |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Interaction |
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| Structure map |
| map07212 | Histamine H1 receptor antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AC Antiallergic agents, excl. corticosteroids
R01AC03 Azelastine
D00659 Azelastine hydrochloride (JP18/USP) <JP/US>
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AX Other antihistamines for systemic use
R06AX19 Azelastine
D00659 Azelastine hydrochloride (JP18/USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01G DECONGESTANTS AND ANTIALLERGICS
S01GX Other antiallergics
S01GX07 Azelastine
D00659 Azelastine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Ophthalmic Agents
Ophthalmic Anti-allergy Agents
Antihistamine
Azelastine
D00659 Azelastine hydrochloride (JP18/USP)
Respiratory Tract/Pulmonary Agents
Antihistamines
Histamine (H1) Receptor Antagonists, Mildly/Non-sedating
Azelastine
D00659 Azelastine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
44 Allergic agents
449 Miscellaneous
4490 Miscellaneous
D00659 Azelastine hydrochloride (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
Allergic agents
52 Antihistamine based drugs
D00659 Azelastine hydrochloride (JP18/USP)
53 Other allergic agents
D00659 Azelastine hydrochloride (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Azelastine
D00659 Azelastine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01036 Azelastine
D00659 Azelastine hydrochloride
Dermatological agent
DG03243 Atopic dermatitis agent
D00659 Azelastine hydrochloride
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D00659 Azelastine hydrochloride
Dermatological agent
DG03243 Atopic dermatitis agent
D00659 Azelastine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D00659 Azelastine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00659 Azelastine hydrochloride
D00659 Azelastine hydrochloride granules
Rx-to-OTC switch list in the USA [br08315.html]
D00659
Rx-to-OTC switch list in Japan [br08314.html]
D00659
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01036 Azelastine
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| Other DBs |
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| KCF data |
ATOM 28
1 X Cl 31.8050 -18.2160
2 C1y C 27.4868 -20.1967
3 C1x C 28.5815 -19.3346
4 C1x C 29.9443 -19.6454
5 N1y N 30.5451 -20.8963
6 C1x C 27.4868 -21.6031
7 C1x C 29.9452 -22.1612
8 C1x C 28.5815 -22.4722
9 N4y N 26.2277 -19.5856
10 N5x N 26.2845 -18.1858
11 C8y C 24.9979 -17.4984
12 C8y C 23.7944 -18.2084
13 C8y C 23.8074 -19.6086
14 C8y C 25.0240 -20.2960
15 C8x C 22.5778 -17.5209
16 C8x C 21.3741 -18.2308
17 C8x C 21.3171 -19.6311
18 C8x C 22.6037 -20.3185
19 C1b C 24.9845 -16.0905
20 C8y C 26.2038 -15.4501
21 C8x C 27.4009 -16.2066
22 C8x C 28.7080 -15.5568
23 C8y C 28.6938 -14.1607
24 C8x C 27.4969 -13.4042
25 C8x C 26.1898 -14.0539
26 X Cl 29.9185 -13.5170
27 C1a C 31.9483 -20.9628
28 O5x O 24.9670 -21.6792
BOND 30
1 4 5 1
2 2 6 1
3 5 7 1
4 3 4 1
5 6 8 1
6 2 3 1
7 7 8 1
8 2 9 1
9 9 10 1
10 10 11 2
11 11 12 1
12 12 13 1
13 13 14 1
14 9 14 1
15 12 15 2
16 15 16 1
17 16 17 2
18 17 18 1
19 13 18 2
20 11 19 1
21 19 20 1
22 20 21 2
23 21 22 1
24 22 23 2
25 23 24 1
26 24 25 2
27 20 25 1
28 23 26 1
29 5 27 1
30 14 28 2
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