KEGG   DRUG: Cevimeline hydrochloride
Entry
D00661                      Drug                                   
Name
Cevimeline hydrochloride (USAN);
Cevimeline hydrochloride hydrate (JAN);
Evoxac (TN);
Saligren (TN)
Product
  Generic
Formula
(C10H17NOS)2. 2HCl. H2O
Exact mass
488.1701
Mol weight
489.5633
Structure
Class
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
 DG01719  Parasympathomimetic agent
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2399
ATC code: N07AX03
Chemical structure group: DG00993
Product (DG00993): D00661<JP/US>
Efficacy
Salivation accelaletor, Muscarinic acetylcholine receptor agonist
  Disease
Sjögren's Syndrome [DS:H01502]
Comment
Arecoline derivative
Target
CHRM3 [HSA:1131] [KO:K04131]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX03 Cevimeline
      D00661  Cevimeline hydrochloride (USAN) <JP/US>
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Cevimeline
   D00661  Cevimeline hydrochloride (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D00661  Cevimeline hydrochloride (USAN); Cevimeline hydrochloride hydrate (JAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01490  Muscarinic cholinergic receptor agonist
   DG00993  Cevimeline
    D00661  Cevimeline hydrochloride
  DG01719  Parasympathomimetic agent
   DG00993  Cevimeline
    D00661  Cevimeline hydrochloride
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00993  Cevimeline
    D00661  Cevimeline hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00993  Cevimeline
     D00661  Cevimeline hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM3
     D00661  Cevimeline hydrochloride (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D00661
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00661
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00661
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00661
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00661
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01490  Muscarinic cholinergic receptor agonist
   DG00993  Cevimeline
  DG01719  Parasympathomimetic agent
   DG00993  Cevimeline
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00993  Cevimeline
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00993  Cevimeline
Other DBs
CAS: 153504-70-2
PubChem: 7847727
ChEBI: 3568
LigandBox: D00661
NIKKAJI: J1.915.230H
KCF data

ATOM        29
            1   C1z C    24.9536  -15.4572
            2   C1y C    24.9536  -14.0450
            3   C1x C    23.6698  -16.2274
            4   C1x C    23.6698  -13.2748
            5   C1x C    24.0550  -14.9437
            6   N1y N    22.3861  -15.4572
            7   C1x C    22.3861  -14.0450
            8   C1x C    23.4130  -14.4302
            9   O2x O    24.9536  -16.8968
            10  C1y C    26.3228  -17.3417
            11  S2x S    27.1689  -16.1770
            12  C1x C    26.3228  -15.0123
            13  C1a C    26.7689  -18.7147
            14  O0  O    31.1826  -14.4759
            15  X   Cl   31.0386  -16.9232
            16  C1z C    24.9536  -15.4572
            17  C1y C    24.9536  -14.0450
            18  C1x C    23.6698  -13.2748
            19  C1x C    22.3861  -14.0450
            20  N1y N    22.3861  -15.4572
            21  C1x C    23.6698  -16.2274
            22  C1x C    23.4130  -14.4302
            23  C1x C    24.0550  -14.9437
            24  O2x O    24.9536  -16.8968
            25  C1y C    26.3228  -17.3417
            26  S2x S    27.1689  -16.1770
            27  C1x C    26.3228  -15.0123
            28  C1a C    26.7689  -18.7147
            29  X   Cl   31.0386  -16.9232
BOND        30
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     6   7 1
            9     6   8 1
            10    1   9 1 #Up
            11    9  10 1
            12   10  11 1
            13   11  12 1
            14    1  12 1
            15   10  13 1 #Down
            16   16  17 1
            17   16  21 1
            18   17  18 1
            19   17  23 1
            20   21  20 1
            21   18  19 1
            22   23  22 1
            23   20  19 1
            24   20  22 1
            25   16  24 1 #Up
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   16  27 1
            30   25  28 1 #Down
BRACKET     1    21.7000  -19.3900   21.7000  -12.8100
            1    28.1400  -12.8100   28.1400  -19.3900
            1  2
 ORIGINAL  1    1   2   4   7   6   3   8   5   9  10  11  12  13
 REPEAT    1   16  17  18  19  20  21  22  23  24  25  26  27  28
            2    29.4700  -17.7800   29.4700  -15.9600
            2    31.7100  -15.9600   31.7100  -17.7800
            2  2
 ORIGINAL  2   15
 REPEAT    2   29

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