| Entry |
|
|---|
| Name |
Chlorpheniramine maleate (JP18/USP);
Chlor-trimeton (TN);
Teldrin (TN) |
|---|
| Formula |
C16H19ClN2. C4H4O4
|
|---|
| Exact mass |
390.1346
|
|---|
| Mol weight |
390.8606
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
|
|---|
| Remark |
| Therapeutic category: | 4419 |
| Product (DG01099): | D00665<JP> |
| Product (mixture): | D04044<JP> D04313<JP> D11075<US> D12312<US> |
|
|---|
| Efficacy |
Antiallergic, H1 receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07212 | Histamine H1 receptor antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AB Substituted alkylamines
R06AB04 Chlorphenamine
D00665 Chlorpheniramine maleate (JP18/USP) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
44 Allergic agents
441 Antihistamines
4419 Others
D00665 Chlorpheniramine maleate (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for nervous and sensory systems
01 Cold remedy (oral use)
D00665 Chlorpheniramine maleate (JP18/USP)
06 Antivertigo drugs (incl. motion/morning sickness remedies)
D00665 Chlorpheniramine maleate (JP18/USP)
Agents for urogenital organs and anus
30 Hemorrhoid drugs for external use
D00665 Chlorpheniramine maleate (JP18/USP)
Allergic agents
52 Antihistamine based drugs
D00665 Chlorpheniramine maleate (JP18/USP)
Agents for integumentary system
57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
D00665 Chlorpheniramine maleate (JP18/USP)
Agents for ophthalmologic use
64 Allergy eye drops
D00665 Chlorpheniramine maleate (JP18/USP)
67 Eyewash
D00665 Chlorpheniramine maleate (JP18/USP)
Agents for otolaryngologic use
69 Oral medicine for nasal inflammation
D00665 Chlorpheniramine maleate (JP18/USP)
70 Nasal sprays for inflammation
D00665 Chlorpheniramine maleate (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Chlorphenamine
D00665 Chlorpheniramine maleate (JP18/USP)
Third-class OTC drugs
Inorganic and organic chemicals
Chlorphenamine
D00665 Chlorpheniramine maleate (JP18/USP)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01099 Chlorphenamine
D00665 Chlorpheniramine maleate
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D00665 Chlorpheniramine maleate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D00665 Chlorpheniramine maleate (JP18/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00665 Chlorpheniramine maleate
D00665 Chlorpheniramine maleate tablets
D00665 Chlorpheniramine maleate powder
D00665 Chlorpheniramine maleate injection
Rx-to-OTC switch list in the USA [br08315.html]
D00665
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01099 Chlorphenamine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 27
1 C2b C 19.2774 -11.8495
2 C2b C 17.7264 -11.8554
3 C6a C 19.9250 -12.9665
4 C6a C 17.0845 -12.9784
5 O6a O 19.2832 -14.0898
6 O6a O 21.2204 -12.9607
7 O6a O 15.7890 -12.9784
8 O6a O 17.7381 -14.0956
9 C8x C 7.0000 -14.8400
10 C8y C 7.0000 -16.2400
11 C8x C 8.2124 -16.9400
12 C8x C 9.4249 -16.2400
13 C8y C 9.4249 -14.8400
14 C8x C 8.2124 -14.1400
15 C8x C 11.8497 -16.2400
16 C8y C 11.8497 -14.8400
17 C1c C 10.6373 -14.1400
18 C8x C 13.0622 -16.9400
19 C8x C 14.2746 -16.2400
20 C8x C 14.2746 -14.8400
21 N5x N 13.0622 -14.1400
22 X Cl 5.7876 -16.9400
23 C1b C 10.6373 -12.7400
24 C1b C 11.8518 -12.0388
25 N1c N 11.8518 -10.6402
26 C1a C 13.0479 -9.9495
27 C1a C 10.6230 -9.9306
BOND 27
1 1 2 2
2 1 3 1
3 2 4 1
4 3 5 1
5 3 6 2
6 4 7 1
7 4 8 2
8 9 10 2
9 10 11 1
10 11 12 2
11 12 13 1
12 13 14 2
13 9 14 1
14 15 16 1
15 16 17 1
16 13 17 1
17 15 18 2
18 18 19 1
19 19 20 2
20 20 21 1
21 16 21 2
22 10 22 1
23 17 23 1
24 23 24 1
25 24 25 1
26 25 26 1
27 25 27 1
|
|---|
