| Entry |
|
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| Name |
Dexchlorpheniramine maleate (USP);
d-Chlorpheniramine maleate (JP18);
Mylaramine (TN);
Polaramine (TN) |
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| Product |
|
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| Generic |
|
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| Formula |
C16H19ClN2. C4H4O4
|
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| Exact mass |
390.1346
|
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| Mol weight |
390.8606
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
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| Remark |
| Therapeutic category: | 4419 |
| Product (DG01098): | D00668<JP/US> |
| Product (mixture): | D04447<JP> |
|
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| Efficacy |
Antiallergic, Antipruritic, H1 receptor antagonist |
|---|
| Disease |
Perennial and seasonal allergic rhinitis [DS: H01360] |
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
|
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| Metabolism |
|
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
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| Structure map |
| map07212 | Histamine H1 receptor antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AB Substituted alkylamines
R06AB02 Dexchlorpheniramine
D00668 Dexchlorpheniramine maleate (USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
44 Allergic agents
441 Antihistamines
4419 Others
D00668 Dexchlorpheniramine maleate (USP); d-Chlorpheniramine maleate (JP18)
Classification of Japanese OTC drugs [BR:br08313]
Agents for nervous and sensory systems
01 Cold remedy (oral use)
D00668 Dexchlorpheniramine maleate (USP)
06 Antivertigo drugs (incl. motion/morning sickness remedies)
D00668 Dexchlorpheniramine maleate (USP)
Allergic agents
52 Antihistamine based drugs
D00668 Dexchlorpheniramine maleate (USP)
Agents for otolaryngologic use
69 Oral medicine for nasal inflammation
D00668 Dexchlorpheniramine maleate (USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Chlorphenamine
D00668 Dexchlorpheniramine maleate (USP)
Third-class OTC drugs
Inorganic and organic chemicals
Chlorphenamine
D00668 Dexchlorpheniramine maleate (USP)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01098 Dexchlorpheniramine
D00668 Dexchlorpheniramine maleate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01098 Dexchlorpheniramine
D00668 Dexchlorpheniramine maleate
DG01633 CYP3A/CYP3A4 substrate
DG01098 Dexchlorpheniramine
D00668 Dexchlorpheniramine maleate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG01098 Dexchlorpheniramine
D00668 Dexchlorpheniramine maleate
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D00668 Dexchlorpheniramine maleate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D00668 Dexchlorpheniramine maleate (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00668 d-Chlorpheniramine maleate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00668
Rx-to-OTC switch list in the USA [br08315.html]
D00668
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01098 Dexchlorpheniramine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01098 Dexchlorpheniramine
DG01633 CYP3A/CYP3A4 substrate
DG01098 Dexchlorpheniramine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG01098 Dexchlorpheniramine
|
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| Other DBs |
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| KCF data |
ATOM 27
1 C8x C 20.6148 -17.3864
2 C8y C 20.6148 -18.7909
3 C8x C 21.8313 -19.4932
4 C8x C 23.0477 -18.7909
5 C8y C 23.0477 -17.3864
6 C8x C 21.8313 -16.6840
7 C8x C 25.4806 -18.7909
8 C8y C 25.4806 -17.3864
9 C1c C 24.2641 -16.6840
10 C8x C 26.6971 -19.4932
11 C8x C 27.9134 -18.7909
12 C8x C 27.9134 -17.3864
13 N5x N 26.6971 -16.6840
14 X Cl 19.3984 -19.4932
15 C1b C 24.2641 -15.2794
16 C1b C 25.4827 -14.5758
17 N1c N 25.4827 -13.1727
18 C1a C 26.6827 -12.4797
19 C1a C 24.2497 -12.4607
20 C6a C 33.4389 -15.9340
21 C2b C 32.7702 -14.7804
22 O6a O 32.8450 -17.1623
23 O6a O 34.7766 -15.9277
24 C2b C 31.1688 -14.7865
25 C6a C 30.5061 -15.9461
26 O6a O 29.1684 -15.9461
27 O6a O 31.1811 -17.1684
BOND 27
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 8 13 2
15 2 14 1
16 9 15 1 #Down
17 15 16 1
18 16 17 1
19 17 18 1
20 17 19 1
21 20 21 1
22 20 22 1
23 20 23 2
24 21 24 2
25 24 25 1
26 25 26 1
27 25 27 2
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