 | | DRUG: Diphenhydramine hydrochloride | |
| Entry |
|
|---|
| Name |
Diphenhydramine hydrochloride (JP18/USP);
Benadryl (TN) |
|---|
| Product |
|
|---|
| Generic |
DIPHENHYDRAMINE (Fresenius Kabi USA), DIPHENHYDRAMINE (Fresenius Kabi USA), DIPHENHYDRAMINE (Micro Labs Limited), DIPHENHYDRAMINE (REMEDYREPACK), DIPHENHYDRAMINE HYDROCHLORIDE (A-S Medication Solutions), DIPHENHYDRAMINE HYDROCHLORIDE (A-S Medication Solutions), DIPHENHYDRAMINE HYDROCHLORIDE (Armas Pharmaceuticals), DIPHENHYDRAMINE HYDROCHLORIDE (Cardinal Health 107), DIPHENHYDRAMINE HYDROCHLORIDE (Cardinal Health 107), DIPHENHYDRAMINE HYDROCHLORIDE (Fresenius Kabi USA), DIPHENHYDRAMINE HYDROCHLORIDE (Gland Pharma Limited), DIPHENHYDRAMINE HYDROCHLORIDE (HF Acquisition Co LLC), DIPHENHYDRAMINE HYDROCHLORIDE (HF Acquisition Co LLC), DIPHENHYDRAMINE HYDROCHLORIDE (HF Acquisition Co. LLC), DIPHENHYDRAMINE HYDROCHLORIDE (Henry Schein), DIPHENHYDRAMINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), DIPHENHYDRAMINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), DIPHENHYDRAMINE HYDROCHLORIDE (Medical Purchasing Solutions), DIPHENHYDRAMINE HYDROCHLORIDE (Medical Purchasing Solutions), DIPHENHYDRAMINE HYDROCHLORIDE (Medical Purchasing Solutions), DIPHENHYDRAMINE HYDROCHLORIDE (Mylan Institutional LLC), DIPHENHYDRAMINE HYDROCHLORIDE (PAI Holdings), DIPHENHYDRAMINE HYDROCHLORIDE (REMEDYREPACK), DIPHENHYDRAMINE HYDROCHLORIDE (REMEDYREPACK) |
|---|
| Formula |
C17H21NO. HCl
|
|---|
| Exact mass |
291.139
|
|---|
| Mol weight |
291.8157
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
|
|---|
| Remark |
| Therapeutic category: | 4411 |
| Product (DG00390): | D00300<JP> D00669<JP/US> D00520<JP/US> |
| Product (mixture): | D04259<JP> D04806<JP> D08769<JP> |
|
|---|
| Efficacy |
Antiallergic, H1 receptor antagonist |
|---|
| Disease |
|
|---|
| Comment |
Diphenhydramine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07212 | Histamine H1 receptor antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04AA Antihistamines for topical use
D04AA32 Diphenhydramine
D00669 Diphenhydramine hydrochloride (JP18/USP) <JP/US>
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AA Aminoalkyl ethers
R06AA02 Diphenhydramine
D00669 Diphenhydramine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antiemetics
Antiemetics, Other
Diphenhydramine
D00669 Diphenhydramine hydrochloride (JP18/USP)
Antiparkinson Agents
Anticholinergics
Diphenhydramine
D00669 Diphenhydramine hydrochloride (JP18/USP)
Respiratory Tract/Pulmonary Agents
Antihistamines
Histamine (H1) Receptor Antagonists, Sedating
Diphenhydramine
D00669 Diphenhydramine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
44 Allergic agents
441 Antihistamines
4411 Diphenhydramines
D00669 Diphenhydramine hydrochloride (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for nervous and sensory systems
01 Cold remedy (oral use)
D00669 Diphenhydramine hydrochloride (JP18/USP)
04 Sedative hypnotic agents
D00669 Diphenhydramine hydrochloride (JP18/USP)
06 Antivertigo drugs (incl. motion/morning sickness remedies)
D00669 Diphenhydramine hydrochloride (JP18/USP)
Allergic agents
52 Antihistamine based drugs
D00669 Diphenhydramine hydrochloride (JP18/USP)
Agents for integumentary system
57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
D00669 Diphenhydramine hydrochloride (JP18/USP)
Agents for ophthalmologic use
64 Allergy eye drops
D00669 Diphenhydramine hydrochloride (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Diphenhydramine
D00669 Diphenhydramine hydrochloride (JP18/USP)
Second-class OTC drugs
Inorganic and organic chemicals
Diphenhydramine
D00669 Diphenhydramine hydrochloride (JP18/USP)
Third-class OTC drugs
Inorganic and organic chemicals
Diphenhydramine
D00669 Diphenhydramine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00390 Diphenhydramine
D00669 Diphenhydramine hydrochloride
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D00669 Diphenhydramine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D00669 Diphenhydramine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00669 Diphenhydramine hydrochloride
Rx-to-OTC switch list in the USA [br08315.html]
D00669
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00390 Diphenhydramine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 20
1 X Cl 34.6500 -16.2400
2 C1c C 28.0247 -15.1856
3 C8y C 26.8139 -15.8899
4 C8y C 29.2415 -15.8899
5 O2a O 28.0306 -13.7884
6 C8x C 26.8139 -17.2930
7 C8x C 25.6030 -15.1856
8 C8x C 29.2358 -17.2930
9 C8x C 30.4465 -15.1856
10 C1b C 29.2415 -13.0840
11 C8x C 25.6030 -17.9856
12 C8x C 24.3862 -15.8899
13 C8x C 30.4465 -17.9856
14 C8x C 31.6632 -15.8899
15 C8x C 24.3862 -17.2930
16 C8x C 31.6573 -17.2930
17 C1b C 30.4774 -13.7950
18 N1c N 31.6739 -13.1016
19 C1a C 32.8632 -13.7857
20 C1a C 31.6717 -11.6927
BOND 20
1 6 11 2
2 7 12 1
3 8 13 1
4 9 14 2
5 11 15 1
6 13 16 2
7 12 15 2
8 14 16 1
9 2 3 1
10 2 4 1
11 2 5 1
12 3 6 1
13 3 7 2
14 4 8 2
15 4 9 1
16 5 10 1
17 10 17 1
18 17 18 1
19 18 19 1
20 18 20 1
|
|---|
|
» Japanese version » Back
|
|