KEGG   DRUG: Ondansetron hydrochloride hydrate
Entry
D00678                      Drug                                   
Name
Ondansetron hydrochloride hydrate (JAN/USP);
Ondansetron hydrochloride;
Zofran (TN)
Product
  Generic
ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (ACTAVIS PHARMA), ONDANSETRON (Accord Healthcare), ONDANSETRON (Accord Healthcare), ONDANSETRON (Advanced Rx Pharmacy of Tennessee), ONDANSETRON (Advanced Rx Pharmacy of Tennessee), ONDANSETRON (American Health Packaging), ONDANSETRON (American Health Packaging), ONDANSETRON (Amneal Pharmaceuticals LLC), ONDANSETRON (Apotex Corp.), ONDANSETRON (Athenex Pharmaceutical Division), ONDANSETRON (Aurobindo Pharma Limited), ONDANSETRON (AvPAK), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Cardinal Health 107), ONDANSETRON (Cardinal Health 107), ONDANSETRON (Cardinal Health 107), ONDANSETRON (Cardinal Health 107), ONDANSETRON (Chartwell RX), ONDANSETRON (Civica), ONDANSETRON (Direct_Rx), ONDANSETRON (Direct_Rx), ONDANSETRON (Eugia US LLC), ONDANSETRON (Eywa Pharma), ONDANSETRON (Fosun Pharma USA), ONDANSETRON (Fresenius Kabi USA), ONDANSETRON (Fresenius Kabi USA), ONDANSETRON (Fresenius Kabi USA), ONDANSETRON (Gland Pharma Limited), ONDANSETRON (Gland Pharma Limited), ONDANSETRON (Glenmark Pharmaceuticals), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (Henry Schein), ONDANSETRON (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), ONDANSETRON (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), ONDANSETRON (Hikma Pharmaceuticals USA), ONDANSETRON (Hikma Pharmaceuticals USA), ONDANSETRON (Hospira), ONDANSETRON (Lannett Company), ONDANSETRON (Major Pharmaceuticals), ONDANSETRON (McKesson Corporation dba SKY Packaging), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (Medical Purchasing Solutions), ONDANSETRON (Natco Pharma Limited), ONDANSETRON (Natco Pharma USA LLC), ONDANSETRON (NorthStar Rx LLC), ONDANSETRON (NorthStar Rx LLC), ONDANSETRON (Northwind Pharmaceuticals), ONDANSETRON (Northwind Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PharmPak), ONDANSETRON (Pharmasource Meds), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Qilu Pharmaceutical), ONDANSETRON (Quality Care Products), ONDANSETRON (REMEDYREPACK), ONDANSETRON (REMEDYREPACK), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (RedPharm Drug), ONDANSETRON (ST. MARY'S MEDICAL PARK PHARMACY), ONDANSETRON (Sagent Pharmaceuticals), ONDANSETRON (St. Mary's Medical Park Pharmacy), ONDANSETRON (Sun Pharmaceutical Industries), ONDANSETRON (Taro Pharmaceuticals U.S.A.), ONDANSETRON (West-Ward Pharmaceuticals Corp), ONDANSETRON HCL (Advanced Rx Pharmacy of Tennessee), ONDANSETRON HCL (Advanced Rx Pharmacy of Tennessee), ONDANSETRON HCL (Advanced Rx Pharmacy of Tennessee), ONDANSETRON HYDROCHLORIDE (A-S Medication Solutions), ONDANSETRON HYDROCHLORIDE (A-S Medication Solutions), ONDANSETRON HYDROCHLORIDE (A-S Medication Solutions), ONDANSETRON HYDROCHLORIDE (American Health Packaging), ONDANSETRON HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), ONDANSETRON HYDROCHLORIDE (Aurobindo Pharma Limited), ONDANSETRON HYDROCHLORIDE (AvPAK), ONDANSETRON HYDROCHLORIDE (Baxter Healthcare Corporation), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack), ONDANSETRON HYDROCHLORIDE (Cardinal Health 107), ONDANSETRON HYDROCHLORIDE (Cardinal Health 107), ONDANSETRON HYDROCHLORIDE (Cardinal Health 107), ONDANSETRON HYDROCHLORIDE (Cardinal Health 107), ONDANSETRON HYDROCHLORIDE (Chartwell RX), ONDANSETRON HYDROCHLORIDE (Denton Pharma), ONDANSETRON HYDROCHLORIDE (Denton Pharma), ONDANSETRON HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), ONDANSETRON HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), ONDANSETRON HYDROCHLORIDE (Hikma Pharmaceuticals USA), ONDANSETRON HYDROCHLORIDE (Major Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NCS HealthCare of KY), ONDANSETRON HYDROCHLORIDE (Northwind Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Northwind Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Northwind Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Northwind Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (NuCare Pharmceuticals), ONDANSETRON HYDROCHLORIDE (PD-Rx Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (PD-Rx Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Pharmpak), ONDANSETRON HYDROCHLORIDE (Precision Dose), ONDANSETRON HYDROCHLORIDE (Preferred Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Preferred Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Proficient Rx LP), ONDANSETRON HYDROCHLORIDE (Proficient Rx LP), ONDANSETRON HYDROCHLORIDE (Proficient Rx LP), ONDANSETRON HYDROCHLORIDE (QPharma), ONDANSETRON HYDROCHLORIDE (QPharma), ONDANSETRON HYDROCHLORIDE (QPharma), ONDANSETRON HYDROCHLORIDE (Quality Care Products LLC), ONDANSETRON HYDROCHLORIDE (Quality Care Products LLC), ONDANSETRON HYDROCHLORIDE (REMEDYREPACK), ONDANSETRON HYDROCHLORIDE (RPK Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (RPK Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (RPK Pharmaceuticals), ONDANSETRON HYDROCHLORIDE (Rising Pharma Holdings), ONDANSETRON HYDROCHLORIDE (ST. MARY'S MEDICAL PARK PHARMACY), ONDANSETRON HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), ONDANSETRON HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), ONDANSETRON HYDROCHLORIDE (Steriscience Specialties Private Limited), ONDANSETRON HYDROCHLORIDE (Steriscience Specialties Private Limited), ONDANSETRON HYDROCHLORIDE (Sun Pharmaceutical Industries), ONDANSETRON HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), ONDANSETRON HYDROCHLORIDE (medsource pharmaceuticals)
Formula
C18H19N3O. 2H2O. HCl
Exact mass
365.1506
Mol weight
365.8545
Structure
Simcomp
Class
Gastrointestinal agent
 DG01489  5-HT3-receptor antagonist
 DG01762  Antiemetic
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2391
ATC code: A04AA01
Chemical structure group: DG00060
Product (DG00060): D00456<US> D00678<JP/US>
Efficacy
Anti-emetic, Serotonin 5-HT3 receptor antagonist
Target
HTR3 [HSA:3359 9177 170572 200909 285242] [KO:K04819]
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Structure map
map07211  Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AA Serotonin (5HT3) antagonists
     A04AA01 Ondansetron
      D00678  Ondansetron hydrochloride hydrate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Antiemetics
  Emetogenic Therapy Adjuncts
   Ondansetron
    D00678  Ondansetron hydrochloride hydrate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2391  Antiemetics
     D00678  Ondansetron hydrochloride hydrate (JAN/USP)
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01489  5-HT3-receptor antagonist
   DG00060  Ondansetron
    D00678  Ondansetron hydrochloride hydrate
  DG01762  Antiemetic
   DG00060  Ondansetron
    D00678  Ondansetron hydrochloride hydrate
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00060  Ondansetron
    D00678  Ondansetron hydrochloride hydrate
  DG01644  CYP2D6 substrate
   DG00060  Ondansetron
    D00678  Ondansetron hydrochloride hydrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00060  Ondansetron
     D00678  Ondansetron hydrochloride hydrate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Serotonin
    HTR3
     D00678  Ondansetron hydrochloride hydrate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00678
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01489  5-HT3-receptor antagonist
   DG00060  Ondansetron
  DG01762  Antiemetic
   DG00060  Ondansetron
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00060  Ondansetron
  DG01644  CYP2D6 substrate
   DG00060  Ondansetron
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00060  Ondansetron
Other DBs
CAS: 103639-04-9
PubChem: 7847744
ChEBI: 7774
LigandBox: D00678
NIKKAJI: J1.630.992C
KCF data

ATOM        25
            1   C8y C    27.9300   -8.4700
            2   C8y C    29.2600   -8.9600
            3   C8y C    27.9300   -7.0700
            4   C5x C    26.7400   -9.1700
            5   C8y C    30.0300   -7.7700
            6   C8x C    29.8200  -10.2200
            7   N4y N    29.2600   -6.6500
            8   C1x C    26.7400   -6.3700
            9   C1y C    25.4800   -8.4700
            10  O5x O    26.7400  -10.5700
            11  C8x C    31.4300   -7.9100
            12  C8x C    31.2200  -10.3600
            13  C1a C    29.6800   -5.3200
            14  C1x C    25.4800   -7.0700
            15  C1b C    24.2900   -9.1700
            16  C8x C    32.0600   -9.2400
            17  N4y N    23.1000   -8.4700
            18  C8y C    23.1000   -7.0700
            19  C8x C    21.7000   -8.8900
            20  N5x N    21.7700   -6.5800
            21  C1a C    24.2900   -6.3000
            22  C8x C    20.9300   -7.7000
            23  X   Cl   34.7900   -6.5800
            24  O0  O    35.4900   -8.5400
            25  O0  O    35.4900   -8.5400
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 2
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13    8  14 1
            14    9  15 1
            15   11  16 1
            16   15  17 1
            17   17  18 1
            18   17  19 1
            19   18  20 2
            20   18  21 1
            21   19  22 2
            22    5   7 1
            23    9  14 1
            24   12  16 2
            25   20  22 1
BRACKET     1    33.3200   -9.3800   33.3200   -7.7700
            1    35.9800   -7.7700   35.9800   -9.3800
            1  2
 ORIGINAL  1   24
 REPEAT    1   25

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Chemical substance (3)   
   PubChem (1)   
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