| Entry |
|
|---|
| Name |
Dyphylline (USP);
Diprophylline (JAN/INN);
Lufyllin (TN) |
|---|
| Formula |
C10H14N4O4
|
|---|
| Exact mass |
254.1015
|
|---|
| Mol weight |
254.2426
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Respiratory system agent
DG01616 Xanthine derivative
DG01609 Xanthine-type bronchodilator
|
|---|
| Remark |
| Therapeutic category: | 2115 |
| Product (mixture): | D04259<JP> D04261<JP> D04342<JP> D08695<JP> |
|
|---|
| Efficacy |
Bronchodilator, Cardiotonic, Phosphodiesterase inhibitor |
|---|
| Comment |
Xanthine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03D OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03DA Xanthines
R03DA01 Diprophylline
D00691 Dyphylline (USP) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
211 Cardiotonics
2115 Caffeines
D00691 Dyphylline (USP); Diprophylline (JAN/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for respiratory organs
26 Antitussives and expectorants
D00691 Dyphylline (USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Diprophylline
D00691 Dyphylline (USP)
Drug groups [BR:br08330]
Respiratory system agent
DG01616 Xanthine derivative
DG01609 Xanthine-type bronchodilator
D00691 Dyphylline
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adenosine
ADORA1
D00691 Dyphylline (USP) <JP>
ADORA2B
D00691 Dyphylline (USP) <JP>
Enzymes
Hydrolases (EC3)
Phosphodiesterases
PDE
D00691 Dyphylline (USP) <JP>
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 18
1 C8y C 28.1400 -17.7100
2 C8y C 28.1400 -19.1100
3 N4y N 26.8100 -17.2900
4 C8y C 29.3300 -17.0100
5 N4y N 29.3300 -19.8100
6 N5x N 26.8100 -19.6000
7 C1b C 25.6200 -16.5900
8 C8x C 25.9700 -18.4800
9 N4y N 30.5900 -17.7100
10 O5x O 29.3300 -15.6100
11 C8y C 30.5900 -19.1100
12 C1a C 29.3300 -21.2800
13 C1c C 24.4300 -17.2900
14 C1a C 31.7800 -17.0100
15 O5x O 31.7800 -19.8100
16 C1b C 23.1700 -16.5900
17 O1a O 24.4300 -18.6900
18 O1a O 21.9800 -17.2900
BOND 19
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 1
8 4 9 1
9 4 10 2
10 5 11 1
11 5 12 1
12 7 13 1
13 9 14 1
14 11 15 2
15 13 16 1
16 13 17 1
17 16 18 1
18 6 8 2
19 9 11 1
|
|---|
