 | | DRUG: Zolpidem tartrate | |
| Entry |
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| Name |
Zolpidem tartrate (JP18/USP);
Ambien (TN);
Intermezzo (TN) |
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| Product |
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| Generic |
ZOLPIDEM (ACI Healthcare USA), ZOLPIDEM (Aphena Pharma Solutions - Tennessee), ZOLPIDEM (Bryant Ranch Prepack), ZOLPIDEM (Bryant Ranch Prepack), ZOLPIDEM (Bryant Ranch Prepack), ZOLPIDEM (Bryant Ranch Prepack), ZOLPIDEM (Bryant Ranch Prepack), ZOLPIDEM (Bryant Ranch Prepack), ZOLPIDEM (Bryant Ranch Prepack), ZOLPIDEM (Bryant Ranch Prepack), ZOLPIDEM (Bryant Ranch Prepack), ZOLPIDEM (Bryant Ranch Prepack), ZOLPIDEM (NuCare Pharmaceuticals), ZOLPIDEM (NuCare Pharmaceuticals), ZOLPIDEM (NuCare Pharmaceuticals), ZOLPIDEM (Proficient Rx LP), ZOLPIDEM TARTRATE (A-S Medication Solutions), ZOLPIDEM TARTRATE (A-S Medication Solutions), ZOLPIDEM TARTRATE (A-S Medication Solutions), ZOLPIDEM TARTRATE (A-S Medication Solutions), ZOLPIDEM TARTRATE (A-S Medication Solutions), ZOLPIDEM TARTRATE (A-S Medication Solutions), ZOLPIDEM TARTRATE (A-S Medication Solutions), ZOLPIDEM TARTRATE (A-S Medication Solutions), ZOLPIDEM TARTRATE (Advanced Rx Pharmacy of Tennessee), ZOLPIDEM TARTRATE (Advanced Rx Pharmacy of Tennessee), ZOLPIDEM TARTRATE (Advanced Rx Pharmacy of Tennessee), ZOLPIDEM TARTRATE (Advanced Rx Pharmacy of Tennessee), ZOLPIDEM TARTRATE (Advanced Rx Pharmacy of Tennessee), ZOLPIDEM TARTRATE (Advanced Rx Pharmacy of Tennessee), ZOLPIDEM TARTRATE (Advanced Rx Pharmacy of Tennessee), ZOLPIDEM TARTRATE (Advanced Rx Pharmacy of Tennessee), ZOLPIDEM TARTRATE (American Health Packaging), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Aphena Pharma Solutions - Tennessee), ZOLPIDEM TARTRATE (Asclemed USA), ZOLPIDEM TARTRATE (Asclemed USA), ZOLPIDEM TARTRATE (Aurobindo Pharma Limited), ZOLPIDEM TARTRATE (AvKARE), ZOLPIDEM TARTRATE (Breckenridge Pharmaceutical), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Bryant Ranch Prepack), ZOLPIDEM TARTRATE (Cardinal Health 107), ZOLPIDEM TARTRATE (DIRECT RX), ZOLPIDEM TARTRATE (Denton Pharma), ZOLPIDEM TARTRATE (DirectRX), ZOLPIDEM TARTRATE (Direct_Rx), ZOLPIDEM TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), ZOLPIDEM TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), ZOLPIDEM TARTRATE (Lupin Pharmaceuticals), ZOLPIDEM TARTRATE (Lupin Pharmaceuticals), ZOLPIDEM TARTRATE (Major Pharmaceuticals), ZOLPIDEM TARTRATE (McKesson Corporation dba SKY Packaging), ZOLPIDEM TARTRATE (Medsource Pharmaceuticals), ZOLPIDEM TARTRATE (Medsource Pharmaceuticals), ZOLPIDEM TARTRATE (NorthStar Rx LLC), ZOLPIDEM TARTRATE (NuCare Pharmaceuticals), ZOLPIDEM TARTRATE (NuCare Pharmaceuticals), ZOLPIDEM TARTRATE (NuCare Pharmaceuticals), ZOLPIDEM TARTRATE (NuCare Pharmaceuticals), ZOLPIDEM TARTRATE (NuCare Pharmaceuticals), ZOLPIDEM TARTRATE (NuCare Pharmaceuticals), ZOLPIDEM TARTRATE (PD-Rx Pharmaceuticals), ZOLPIDEM TARTRATE (PD-Rx Pharmaceuticals), ZOLPIDEM TARTRATE (PD-Rx Pharmaceuticals), ZOLPIDEM TARTRATE (PD-Rx Pharmaceuticals), ZOLPIDEM TARTRATE (Par Pharmaceutical), ZOLPIDEM TARTRATE (Preferred Pharmaceuticals), ZOLPIDEM TARTRATE (Preferred Pharmaceuticals), ZOLPIDEM TARTRATE (Preferred Pharmaceuticals), ZOLPIDEM TARTRATE (Preferred Pharmaceuticals), ZOLPIDEM TARTRATE (Preferred Pharmaceuticals), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Proficient Rx LP), ZOLPIDEM TARTRATE (Quality Care Products LLC), ZOLPIDEM TARTRATE (Quality Care Products), ZOLPIDEM TARTRATE (Quality Care Products), ZOLPIDEM TARTRATE (REMEDYREPACK), ZOLPIDEM TARTRATE (REMEDYREPACK), ZOLPIDEM TARTRATE (REMEDYREPACK), ZOLPIDEM TARTRATE (REMEDYREPACK), ZOLPIDEM TARTRATE (RPK Pharmaceuticals), ZOLPIDEM TARTRATE (Sandoz), ZOLPIDEM TARTRATE (Sandoz), ZOLPIDEM TARTRATE (St Marys Medical Park Pharmacy), ZOLPIDEM TARTRATE (St. Mary's Medical Park Pharmacy), ZOLPIDEM TARTRATE (Sun Pharmaceutical Industries), ZOLPIDEM TARTRATE (Teva Pharmaceuticals USA), ZOLPIDEM TARTRATE (Torrent Pharmaceuticals Limited), ZOLPIDEM TARTRATE (Winthrop U.S), ZOLPIDEM TARTRATE (medsource pharmaceuticals), ZOLPIDEM TARTRATE SUBLINGUAL (Par Pharmaceutical) |
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| Formula |
(C19H21N3O)2. C4H6O6
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| Exact mass |
764.3534
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| Mol weight |
764.8659
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| Structure |
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| Class |
Neuropsychiatric agent
DG01836 Non-benzodiazepine sedative-hypnotics
DG03202 Hypnotic
DG01567 GABA-A receptor agonist
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01642 CYP2C9 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 1129 |
| Product (DG00922): | D00706<JP/US> |
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| Efficacy |
Sedative-hypnotic |
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| Disease |
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| Comment |
Imidazopyridines
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]; CYP2C9 [HSA: 1559], CYP1A2 [HSA: 1544]
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| Interaction |
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| Structure map |
| map07230 | GABA-A receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05C HYPNOTICS AND SEDATIVES
N05CF Benzodiazepine related drugs
N05CF02 Zolpidem
D00706 Zolpidem tartrate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Sleep Disorder Agents
Sleep Promoting Agents
Zolpidem
D00706 Zolpidem tartrate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
112 Hypnotics and sedatives, anxiolytics
1129 Others
D00706 Zolpidem tartrate (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01836 Non-benzodiazepine sedative-hypnotics
DG00922 Zolpidem
D00706 Zolpidem tartrate
DG03202 Hypnotic
DG00922 Zolpidem
D00706 Zolpidem tartrate
DG01567 GABA-A receptor agonist
DG00922 Zolpidem
D00706 Zolpidem tartrate
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00922 Zolpidem
D00706 Zolpidem tartrate
DG01642 CYP2C9 substrate
DG00922 Zolpidem
D00706 Zolpidem tartrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00922 Zolpidem
D00706 Zolpidem tartrate
Drug classes [BR:br08332]
Neuropsychiatric agent
DG03202 Hypnotic
D00706 Zolpidem tartrate
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D00706 Zolpidem tartrate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00706 Zolpidem tartrate
D00706 Zolpidem tartrate tablets
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00706
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00706
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01836 Non-benzodiazepine sedative-hypnotics
DG00922 Zolpidem
DG03202 Hypnotic
DG00922 Zolpidem
DG01567 GABA-A receptor agonist
DG00922 Zolpidem
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00922 Zolpidem
DG01642 CYP2C9 substrate
DG00922 Zolpidem
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00922 Zolpidem
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| Other DBs |
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| KCF data |
ATOM 56
1 C8y C 19.9502 -16.5666
2 C8y C 20.7843 -15.4409
3 N4y N 18.6204 -16.1292
4 C1b C 19.9445 -17.9607
5 C8y C 22.1841 -15.4469
6 N5x N 19.9562 -14.2979
7 C8y C 18.6263 -14.7236
8 C8x C 17.4130 -16.8291
9 C5a C 21.1576 -18.6547
10 C8x C 22.8783 -16.6542
11 C8x C 22.8900 -14.2336
12 C8x C 17.4130 -14.0237
13 C8y C 16.1942 -16.1234
14 N1c N 21.1576 -20.0546
15 O5a O 22.3709 -17.9490
16 C8x C 24.2782 -16.6600
17 C8x C 24.2898 -14.2395
18 C8x C 16.1942 -14.7236
19 C1a C 14.9809 -16.8291
20 C1a C 22.3709 -20.7428
21 C1a C 19.9445 -20.7487
22 C8y C 24.9838 -15.4585
23 C1a C 26.3837 -15.4643
24 C1c C 32.6423 -17.7973
25 C1c C 33.8437 -17.0974
26 C6a C 31.4292 -17.1033
27 O1a O 32.6423 -19.1972
28 C6a C 35.0570 -17.7856
29 O1a O 33.8437 -15.6918
30 O6a O 30.2159 -17.8032
31 O6a O 31.4233 -15.7035
32 O6a O 36.2701 -17.0916
33 O6a O 35.0511 -19.1914
34 C8y C 19.9502 -16.5666
35 C8y C 20.7843 -15.4409
36 C8y C 22.1841 -15.4469
37 C8x C 22.8783 -16.6542
38 C8x C 24.2782 -16.6600
39 C8y C 24.9838 -15.4585
40 C1a C 26.3837 -15.4643
41 C8x C 24.2898 -14.2395
42 C8x C 22.8900 -14.2336
43 N5x N 19.9562 -14.2979
44 C8y C 18.6263 -14.7236
45 N4y N 18.6204 -16.1292
46 C8x C 17.4130 -16.8291
47 C8y C 16.1942 -16.1234
48 C1a C 14.9809 -16.8291
49 C8x C 16.1942 -14.7236
50 C8x C 17.4130 -14.0237
51 C1b C 19.9445 -17.9607
52 C5a C 21.1576 -18.6547
53 N1c N 21.1576 -20.0546
54 C1a C 22.3709 -20.7428
55 C1a C 19.9445 -20.7487
56 O5a O 22.3709 -17.9490
BOND 59
1 24 25 1
2 24 26 1
3 24 27 1 #Up
4 25 28 1
5 25 29 1 #Up
6 26 30 1
7 26 31 2
8 28 32 1
9 28 33 2
10 1 2 2
11 1 3 1
12 1 4 1
13 2 5 1
14 2 6 1
15 3 7 1
16 3 8 1
17 4 9 1
18 5 10 2
19 5 11 1
20 7 12 1
21 8 13 2
22 9 14 1
23 9 15 2
24 10 16 1
25 11 17 2
26 12 18 2
27 13 19 1
28 14 20 1
29 14 21 1
30 16 22 2
31 22 23 1
32 6 7 2
33 13 18 1
34 17 22 1
35 34 35 2
36 34 45 1
37 34 51 1
38 35 36 1
39 35 43 1
40 45 44 1
41 45 46 1
42 51 52 1
43 36 37 2
44 36 42 1
45 44 50 1
46 46 47 2
47 52 53 1
48 52 56 2
49 37 38 1
50 42 41 2
51 50 49 2
52 47 48 1
53 53 54 1
54 53 55 1
55 38 39 2
56 39 40 1
57 43 44 2
58 47 49 1
59 41 39 1
BRACKET 1 13.0900 -21.8400 13.0900 -12.8100
1 28.1400 -12.8100 28.1400 -21.8400
1 2
ORIGINAL 1 1 2 5 10 16 22 23 17 11 6 7 3 8 13 19 18
1 12 4 9 14 20 21 15
REPEAT 1 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49
1 50 51 52 53 54 55 56
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