| Entry |
|
|---|
| Name |
Metoclopramide (JP18/INN);
Elieten (TN);
Terperan (TN) |
|---|
| Formula |
C14H22ClN3O2
|
|---|
| Exact mass |
299.1401
|
|---|
| Mol weight |
299.7964
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
Gastrointestinal agent
DG01763 Propulsive
DG01489 5-HT3-receptor antagonist
DG01762 Antiemetic
DG01783 Benzamide type antiemetic
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
|---|
| Remark |
| Therapeutic category: | 2399 |
| Product (DG00055): | D00726<JP> D02213<JP> D05008<US> |
|
|---|
| Efficacy |
Anti-emetic, Prokinetic, Dopamine D2 receptor antagonist |
|---|
| Comment |
Benzamide derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
|---|
| Structure map |
| map07211 | Serotonin receptor agonists/antagonists |
| map07213 | Dopamine receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
A03F PROPULSIVES
A03FA Propulsives
A03FA01 Metoclopramide
D00726 Metoclopramide (JP18/INN) <JP>
USP drug classification [BR:br08302]
Antiemetics
Antiemetics, Other
Metoclopramide
D00726 Metoclopramide (JP18/INN)
Gastrointestinal Agents
Gastrointestinal Agents, Other
Metoclopramide
D00726 Metoclopramide (JP18/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
239 Miscellaneous
2399 Others
D00726 Metoclopramide (JP18/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00055 Metoclopramide
D00726 Metoclopramide
Gastrointestinal agent
DG01763 Propulsive
DG00055 Metoclopramide
D00726 Metoclopramide
DG01489 5-HT3-receptor antagonist
DG00055 Metoclopramide
D00726 Metoclopramide
DG01762 Antiemetic
DG01783 Benzamide type antiemetic
DG00055 Metoclopramide
D00726 Metoclopramide
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00055 Metoclopramide
D00726 Metoclopramide
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00055 Metoclopramide
D00726 Metoclopramide
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D00726 Metoclopramide (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00726 Metoclopramide
D00726 Metoclopramide tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00726
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00055 Metoclopramide
Gastrointestinal agent
DG01763 Propulsive
DG00055 Metoclopramide
DG01489 5-HT3-receptor antagonist
DG00055 Metoclopramide
DG01762 Antiemetic
DG01783 Benzamide type antiemetic
DG00055 Metoclopramide
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00055 Metoclopramide
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00055 Metoclopramide
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 20
1 C8y C 27.1658 -16.8047
2 C8y C 27.1658 -15.4044
3 C8x C 25.9755 -17.5049
4 C5a C 28.4261 -17.5049
5 C8x C 25.9755 -14.7043
6 O2a O 28.4261 -14.7043
7 C8y C 24.7854 -16.8047
8 N1b N 29.6164 -16.8047
9 O5a O 28.4261 -18.9052
10 C8y C 24.7854 -15.4044
11 C1a C 29.6164 -15.4044
12 X Cl 23.5951 -17.5049
13 C1b C 30.8766 -17.5049
14 N1a N 23.5951 -14.7043
15 C1b C 32.0669 -16.8047
16 N1c N 33.2572 -17.5049
17 C1b C 34.5175 -16.8047
18 C1b C 33.2572 -18.9052
19 C1a C 35.7077 -17.5049
20 C1a C 34.5175 -19.6053
BOND 20
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 4 8 1
8 4 9 2
9 5 10 1
10 6 11 1
11 7 12 1
12 8 13 1
13 10 14 1
14 13 15 1
15 15 16 1
16 16 17 1
17 16 18 1
18 17 19 1
19 18 20 1
20 7 10 2
|
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