KEGG   DRUG: Interferon gamma-1b
Entry
D00747                      Drug                                   
Name
Interferon gamma-1b (USAN/INN);
Actimmune (TN)
Product
Formula
C734H1166N204O216S5
Exact mass
16454.513
Mol weight
16464.674
Sequence
MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN
FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE
LSPAAKTGKR KRSQMLFRGR
  Type
Peptide
Class
Immunological agent
 DG01752  Interferone
Remark
ATC code: L03AB03
Chemical structure group: DG00737
Product (DG00737): D00747<US> D03357<JP>
Efficacy
Antineoplastic, Immunomodulator, Biological response modifier
  Disease
Chronic granulomatous disease [DS:H00098]
Malignant osteopetrosis [DS:H00436]
Target
IFNGR1 (CD119) [HSA:3459] [KO:K05132]
IFNGR2 [HSA:3460] [KO:K05133]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa05200  Pathways in cancer
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AB Interferons
     L03AB03 Interferon gamma
      D00747  Interferon gamma-1b (USAN/INN) <US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunostimulants
   Interferons
    Interferon Gamma 1b
     D00747  Interferon gamma-1b (USAN/INN)
Drug groups [BR:br08330]
 Immunological agent
  DG01752  Interferone
   DG00737  Interferon gamma
    D00747  Interferon gamma-1b
Drug classes [BR:br08332]
 Immunological agent
  DG01752  Interferone
   D00747  Interferon gamma-1b
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Interferon receptors
    IFNGR1 (CD119)
     D00747  Interferon gamma-1b (USAN/INN) <US>
    IFNGR2
     D00747  Interferon gamma-1b (USAN/INN) <US>
Drug groups [BR:br08330]
 Immunological agent
  DG01752  Interferone
   DG00737  Interferon gamma
Other DBs
CAS: 98059-61-1
PubChem: 7847812
ChEBI: 5939

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