KEGG   DRUG: Metyrosine
Entry
D00762                      Drug                                   
Name
Metyrosine (USP);
Metirosine (JAN/INN);
Demser (TN)
Product
DEMSER (Bausch Health US)
  Generic
METYROSINE (Amneal Pharmaceuticals NY LLC), METYROSINE (Oceanside Pharmaceuticals)
Formula
C10H13NO3
Exact mass
195.0895
Mol weight
195.2151
Structure
Simcomp
Class
Cardiovascular agent
 DG01617  Catecholamine synthesis inhibitors
Remark
Same as: C07921
Therapeutic category: 2190
ATC code: C02KB01
Product: D00762<JP/US>
Efficacy
Antihypertensive, Tyrosine monooxygenase inhibitor
Comment
Tyrosine derivative
Target
TH [HSA:7054] [KO:K00501]
  Pathway
hsa00350  Tyrosine metabolism
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02K OTHER ANTIHYPERTENSIVES
    C02KB Tyrosine hydroxylase inhibitors
     C02KB01 Metirosine
      D00762  Metyrosine (USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D00762  Metyrosine (USP); Metirosine (JAN/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01617  Catecholamine synthesis inhibitors
   D00762  Metyrosine
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Other monooxygenases
    TH
     D00762  Metyrosine (USP) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00762
Other DBs
CAS: 672-87-7
PubChem: 7847827
ChEBI: 6912
LigandBox: D00762
NIKKAJI: J9.465J
KCF data

ATOM        14
            1   C1d C    20.4400  -16.2400
            2   C6a C    21.6300  -15.5400
            3   C1b C    19.2500  -15.5400
            4   C1a C    19.6700  -17.5700
            5   N1a N    21.3500  -17.2900
            6   O6a O    22.8200  -16.2400
            7   O6a O    21.6300  -14.1400
            8   C8y C    17.9900  -16.2400
            9   C8x C    17.9900  -17.5700
            10  C8x C    16.8000  -15.5400
            11  C8x C    16.8000  -18.2700
            12  C8x C    15.6100  -16.2400
            13  C8y C    15.6100  -17.5700
            14  O1a O    14.4200  -18.2700
BOND        14
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 2
            7     3   8 1
            8     8   9 2
            9     8  10 1
            10    9  11 1
            11   10  12 2
            12   11  13 2
            13   13  14 1
            14   12  13 1

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Ontology (5)   
   KEGG BRITE (5)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (5)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (15)   

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