KEGG   DRUG: Riluzole
Entry
D00775                      Drug                                   
Name
Riluzole (JAN/USP/INN);
Rilutek (TN)
Product
  Generic
Formula
C8H5F3N2OS
Exact mass
234.0075
Mol weight
234.1983
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
Remark
Same as: C07937
Therapeutic category: 1190
ATC code: N07XX02
Product: D00775<JP/US>
Efficacy
Nerve cells protectant
  Disease
Amyotrophic lateral sclerosis [DS:H00058]
Comment
Amyotrophic lateral sclerosis treatment
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
hsa05014  Amyotrophic lateral sclerosis
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07X OTHER NERVOUS SYSTEM DRUGS
    N07XX Other nervous system drugs
     N07XX02 Riluzole
      D00775  Riluzole (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Amyotrophic Lateral Sclerosis (ALS) Agents
   Riluzole
    D00775  Riluzole (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D00775  Riluzole (JAN/USP/INN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   D00775  Riluzole
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), non-NMDA
    GRIA
     D00775  Riluzole (JAN/USP/INN) <JP/US>
    GRIK
     D00775  Riluzole (JAN/USP/INN) <JP/US>
   Glutamate (ionotropic), NMDA
    GRIN (NMDAR)
     D00775  Riluzole (JAN/USP/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00775
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00775
Other DBs
CAS: 1744-22-5
PubChem: 7847840
ChEBI: 8863
PDB-CCD: 657[PDBj]
LigandBox: D00775
NIKKAJI: J22.921K
KCF data

ATOM        15
            1   C1d C    22.1906  -18.2535
            2   O2a O    23.4014  -17.5492
            3   X   F    20.9739  -17.5492
            4   X   F    22.1849  -19.6507
            5   X   F    20.9739  -18.9405
            6   C8y C    24.6065  -18.2535
            7   C8x C    25.8233  -17.5492
            8   C8x C    24.6065  -19.6507
            9   C8y C    27.0284  -18.2478
            10  C8x C    25.8233  -20.3494
            11  C8y C    27.0343  -19.6507
            12  S2x S    28.3616  -17.8053
            13  N5x N    28.3733  -20.0757
            14  C8y C    29.1882  -18.9346
            15  N1a N    30.5797  -18.8705
BOND        16
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     6   7 2
            7     6   8 1
            8     7   9 1
            9     8  10 2
            10    9  11 2
            11    9  12 1
            12   11  13 1
            13   12  14 1
            14   14  15 1
            15   10  11 1
            16   13  14 2

» Japanese version   » Back

DBGET integrated database retrieval system