KEGG   DRUG: Ropinirole hydrochloride
Entry
D00784                      Drug                                   
Name
Ropinirole hydrochloride (JAN/USP);
Requip (TN)
Product
  Generic
ROPINIROLE (A-S Medication Solutions), ROPINIROLE (A-S Medication Solutions), ROPINIROLE (A-S Medication Solutions), ROPINIROLE (Accord Healthcare), ROPINIROLE (Actavis Pharma), ROPINIROLE (Alembic Pharmaceuticals Limited), ROPINIROLE (Alembic Pharmaceuticals), ROPINIROLE (Bionpharma), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (DIRECT RX), ROPINIROLE (Direct_Rx), ROPINIROLE (Direct_Rx), ROPINIROLE (Direct_Rx), ROPINIROLE (Dr. Reddys Laboratories Limited), ROPINIROLE (Glenmark Pharmaceuticals), ROPINIROLE (Marlex Pharmaceuticals), ROPINIROLE (REMEDYREPACK), ROPINIROLE (REMEDYREPACK), ROPINIROLE (REMEDYREPACK), ROPINIROLE (REMEDYREPACK), ROPINIROLE (REMEDYREPACK), ROPINIROLE (Sandoz), ROPINIROLE (Solco Healthcare US), ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions), ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions), ROPINIROLE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), ROPINIROLE HYDROCHLORIDE (Alembic Pharmaceuticals), ROPINIROLE HYDROCHLORIDE (American Health Packaging), ROPINIROLE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), ROPINIROLE HYDROCHLORIDE (AvKARE), ROPINIROLE HYDROCHLORIDE (AvPAK), ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack), ROPINIROLE HYDROCHLORIDE (Cardinal Health 107), ROPINIROLE HYDROCHLORIDE (Major Pharmaceuticals), ROPINIROLE HYDROCHLORIDE (NCS HealthCare of KY), ROPINIROLE HYDROCHLORIDE (Northwind Pharmaceuticals), ROPINIROLE HYDROCHLORIDE (Proficient Rx LP), ROPINIROLE HYDROCHLORIDE (REMEDYREPACK), ROPINIROLE HYDROCHLORIDE (SOLCO HEALTHCARE US), ROPINIROLE HYDROCHLORIDE (SOLCO HEALTHCARE US), ROPINIROLE HYDROCHLORIDE (Zydus Lifesciences Limited)
Formula
C16H24N2O. HCl
Exact mass
296.1655
Mol weight
296.8355
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01472  Dopamine agonist
  DG01468  Dopamine D2-receptor agonist
 DG01967  Antiparkinson agent
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
Remark
Therapeutic category: 1169
ATC code: N04BC04
Chemical structure group: DG00862
Product (DG00862): D00784<JP/US>
Efficacy
Antiparkinsonian, Dopamine receptor agonist
  Disease
Parkinson disease [DS:H00057]
Restless legs syndrome [DS:H01597]
Target
DRD2 [HSA:1813] [KO:K04145]
DRD3 [HSA:1814] [KO:K04146]
DRD4 [HSA:1815] [KO:K04147]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
hsa05012  Parkinson disease
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Structure map
map07057  Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BC Dopamine agonists
     N04BC04 Ropinirole
      D00784  Ropinirole hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Dopamine Agonists
   Ropinirole
    D00784  Ropinirole hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D00784  Ropinirole hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01472  Dopamine agonist
   DG01468  Dopamine D2-receptor agonist
    DG00862  Ropinirole
     D00784  Ropinirole hydrochloride
  DG01967  Antiparkinson agent
   DG00862  Ropinirole
    D00784  Ropinirole hydrochloride
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00862  Ropinirole
    D00784  Ropinirole hydrochloride
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01967  Antiparkinson agent
   D00784  Ropinirole hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00784  Ropinirole hydrochloride (JAN/USP) <JP/US>
    DRD3
     D00784  Ropinirole hydrochloride (JAN/USP) <JP/US>
    DRD4
     D00784  Ropinirole hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00784
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00784
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01472  Dopamine agonist
   DG01468  Dopamine D2-receptor agonist
    DG00862  Ropinirole
  DG01967  Antiparkinson agent
   DG00862  Ropinirole
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00862  Ropinirole
Other DBs
CAS: 91374-20-8
PubChem: 7847849
ChEBI: 8889
LigandBox: D00784
KCF data

ATOM        20
            1   C8y C    26.1291  -19.3087
            2   C8y C    24.9204  -18.6139
            3   C8y C    26.1291  -20.7101
            4   C1x C    27.4604  -18.8825
            5   C1b C    24.9204  -17.2007
            6   C8x C    23.6999  -19.3087
            7   N1x N    27.4604  -21.1423
            8   C8x C    24.9204  -21.4225
            9   C5x C    28.2721  -20.0152
            10  C1b C    23.7059  -16.5058
            11  C8x C    23.6999  -20.7159
            12  O5x O    29.6735  -20.0152
            13  N1c N    22.4912  -17.2007
            14  C1b C    21.2767  -16.5058
            15  C1b C    22.4912  -18.5963
            16  C1b C    20.0620  -17.2007
            17  C1b C    21.2767  -19.2970
            18  C1a C    18.8533  -16.5058
            19  C1a C    21.2767  -20.6925
            20  X   Cl   32.6749  -19.9798
BOND        20
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    9  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   17  19 1
            19    7   9 1
            20    8  11 2

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Ontology (8)   
   KEGG BRITE (8)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (2)   
   PubChem (1)   
   ChEBI (1)   
Gene (6)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (3)   
All databases (22)   

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