Entry |
|
Name |
Thioridazine hydrochloride (JP18/USP); Mellaril (TN) |
Product |
|
Generic |
|
Formula |
C21H26N2S2. HCl
|
Exact mass |
406.1304
|
Mol weight |
407.0355
|
Structure |
|
Simcomp |
|
Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
|
Remark |
Product (DG00882): | D00798<US> |
|
Efficacy |
Antipsychotic, Sedative-hypnotic, Dopamine D2 receptor antagonist |
Disease |
|
Comment |
Phenothiazine derivative
|
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Interaction |
|
Structure map |
map07029 | Antipsychotics - phenothiazines |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AC Phenothiazines with piperidine structure
N05AC02 Thioridazine
D00798 Thioridazine hydrochloride (JP18/USP) <US>
USP drug classification [BR:br08302]
Antipsychotics
1st Generation/Typical
Thioridazine
D00798 Thioridazine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00882 Thioridazine
D00798 Thioridazine hydrochloride
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00882 Thioridazine
D00798 Thioridazine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D00798 Thioridazine hydrochloride (JP18/USP) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00798 Thioridazine hydrochloride
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00798
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00882 Thioridazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00882 Thioridazine
|
Other DBs |
|
KCF data |
ATOM 26
1 N1y N 23.5960 -17.9088
2 C8y C 22.3761 -18.6092
3 C8y C 24.8099 -18.6209
4 C1b C 23.5901 -16.5080
5 C8y C 22.3702 -20.0158
6 C8x C 21.1679 -17.9029
7 C8y C 24.7982 -20.0215
8 C8x C 26.0298 -17.9262
9 C1b C 24.8042 -15.8133
10 S2x S 23.5843 -20.7162
11 C8x C 21.1679 -20.7103
12 C8x C 19.9480 -18.6092
13 C8x C 26.0064 -20.7279
14 C8y C 27.2322 -18.6442
15 C1y C 24.8042 -14.4127
16 C8x C 19.9480 -20.0158
17 C8x C 27.2146 -20.0449
18 N1y N 26.0181 -13.7123
19 C1x C 23.5960 -13.7123
20 C1x C 26.0181 -12.3172
21 C1a C 27.2146 -14.4127
22 C1x C 23.5960 -12.3172
23 C1x C 24.8042 -11.6227
24 S2a S 28.4627 -17.9562
25 C1a C 29.7005 -18.6933
26 X Cl 33.2288 -18.0699
BOND 28
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 5 11 1
11 6 12 2
12 7 13 1
13 8 14 2
14 9 15 1
15 11 16 2
16 13 17 2
17 15 18 1
18 15 19 1
19 18 20 1
20 18 21 1
21 19 22 1
22 20 23 1
23 7 10 1
24 12 16 1
25 14 17 1
26 22 23 1
27 14 24 1
28 24 25 1
|