| Entry |
|
|---|
| Name |
Trifluoperazine hydrochloride (JAN/USP);
Stelazine (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C21H24F3N3S. 2HCl
|
|---|
| Exact mass |
479.1177
|
|---|
| Mol weight |
480.4175
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
|
|---|
| Remark |
| Product (DG00877): | D00799<US> |
|
|---|
| Efficacy |
Antipsychotic, Sedative-hypnotic, Dopamine D2 receptor antagonist |
|---|
| Disease |
|
|---|
| Comment |
Phenothiazine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07029 | Antipsychotics - phenothiazines |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AB Phenothiazines with piperazine structure
N05AB06 Trifluoperazine
D00799 Trifluoperazine hydrochloride (JAN/USP) <US>
USP drug classification [BR:br08302]
Antipsychotics
1st Generation/Typical
Trifluoperazine
D00799 Trifluoperazine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00877 Trifluoperazine
D00799 Trifluoperazine hydrochloride
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00877 Trifluoperazine
D00799 Trifluoperazine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D00799 Trifluoperazine hydrochloride (JAN/USP) <US>
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00877 Trifluoperazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00877 Trifluoperazine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 30
1 C8y C 20.9546 -18.6482
2 N1y N 22.1730 -17.9486
3 C8y C 20.9487 -20.0474
4 C8x C 19.7478 -17.9427
5 C8y C 23.3855 -18.6540
6 C1b C 22.1730 -16.5437
7 S2x S 22.1613 -20.7527
8 C8x C 19.7478 -20.7470
9 C8x C 18.5294 -18.6482
10 C8y C 23.3739 -20.0531
11 C8x C 24.5980 -17.9661
12 C1b C 23.3798 -15.8499
13 C8x C 18.5294 -20.0474
14 C8x C 24.5749 -20.7586
15 C8y C 25.8048 -18.6773
16 C1b C 23.3798 -14.4567
17 C8x C 25.8631 -20.0765
18 N1y N 24.5865 -13.7512
19 C1x C 25.7991 -14.4507
20 C1x C 24.5865 -12.3520
21 C1x C 27.0116 -13.7454
22 C1x C 25.7991 -11.6526
23 N1y N 27.0116 -12.3463
24 C1a C 28.2243 -11.6409
25 C1d C 27.0183 -17.9497
26 X F 28.2100 -17.2200
27 X F 27.7200 -19.1100
28 X F 26.3200 -16.7300
29 X Cl 31.6716 -18.2170
30 X Cl 31.6716 -18.2170
BOND 31
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 1
8 4 9 2
9 5 10 2
10 5 11 1
11 6 12 1
12 8 13 2
13 10 14 1
14 11 15 2
15 12 16 1
16 14 17 2
17 16 18 1
18 18 19 1
19 18 20 1
20 19 21 1
21 20 22 1
22 21 23 1
23 23 24 1
24 7 10 1
25 9 13 1
26 15 17 1
27 22 23 1
28 15 25 1
29 25 26 1
30 25 27 1
31 25 28 1
BRACKET 1 30.2400 -18.9000 30.2400 -17.2200
1 32.2700 -17.2200 32.2700 -18.9000
1 2
ORIGINAL 1 29
REPEAT 1 30
|
|---|
