 | | DRUG: Morphine sulfate | |
| Entry |
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| Name |
Morphine sulfate (USP);
Morphine sulfate hydrate (JP18);
Morphine sulfate pentahydrate;
Astramor PH (TN);
Avinza (TN);
Depodur (TN);
Kadian (TN);
MS contin (TN) |
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| Product |
DURAMORPH (Hikma Pharmaceuticals USA), MORPHINE SULFATE (ATLANTIC BIOLOGICALS CORP.), MORPHINE SULFATE (ATLANTIC BIOLOGICALS CORP.), MORPHINE SULFATE (American Health Packaging), MORPHINE SULFATE (Fresenius Kabi USA), MORPHINE SULFATE (Fresenius Kabi USA), MORPHINE SULFATE (Fresenius Kabi), MORPHINE SULFATE (Hikma Pharmaceuticals USA), MORPHINE SULFATE (Hikma Pharmaceuticals USA), MORPHINE SULFATE (Hikma Pharmaceuticals USA), MORPHINE SULFATE (Hospira), MORPHINE SULFATE (Hospira), MORPHINE SULFATE (PAI Holdings), MORPHINE SULFATE (Precision Dose), MORPHINE SULFATE (Precision Dose), MORPHINE SULFATE (Precision Dose), MORPHINE SULFATE (Precision Dose), MORPHINE SULFATE (Precision Dose), MORPHINE SULFATE (Quality Care Products LLC), MS CONTIN (Rhodes Pharmaceuticals L.P.) |
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| Generic |
MITIGO (Piramal Critical Care), MORPHINE SULFATE (Actavis Pharma), MORPHINE SULFATE (Actavis Pharma), MORPHINE SULFATE (American Health Packaging), MORPHINE SULFATE (American Health Packaging), MORPHINE SULFATE (Amneal Pharmaceuticals of New York LLC), MORPHINE SULFATE (Ascend Laboratories), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Civica), MORPHINE SULFATE (Hikma Pharmaceuticals USA), MORPHINE SULFATE (Hospira), MORPHINE SULFATE (International Medication Systems), MORPHINE SULFATE (Lupin Pharmaceuticals), MORPHINE SULFATE (Major Pharmaceuticals), MORPHINE SULFATE (Mayne Pharma Commercial LLC), MORPHINE SULFATE (Mayne Pharma Commercial LLC), MORPHINE SULFATE (Nortec Development Associates), MORPHINE SULFATE (Novel Laboratories), MORPHINE SULFATE (PAI Holdings), MORPHINE SULFATE (Quality Care Products LLC), MORPHINE SULFATE (Quality Care Products), MORPHINE SULFATE (Quality Care Products), MORPHINE SULFATE (Quality Care Products), MORPHINE SULFATE (Rhodes Pharmaceuticals L. P.), MORPHINE SULFATE (SpecGx LLC), MORPHINE SULFATE (SpecGx LLC), MORPHINE SULFATE (SpecGx LLC), MORPHINE SULFATE (Sun Pharmaceutical Industries), MORPHINE SULFATE (Tris Pharma), MORPHINE SULFATE (Upsher-Smith Laboratories), MORPHINE SULFATE (Upsher-Smith Laboratories), MORPHINE SULFATE (Winder Laboratories LLC) |
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| Formula |
(C17H19NO3)2. H2SO4. 5H2O
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| Exact mass |
758.2932
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| Mol weight |
758.8302
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
Analgesic
DG01984 Opioid analgesics
Metabolizing enzyme substrate
DG02924 UGT substrate
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| Remark |
| Therapeutic category: | 8114 |
| Product (DG00810): | D00842<JP/US> D02271<JP> |
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| Efficacy |
Analgesic (narcotic), Opioid receptor agonist |
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| Comment |
Opium alkaloid
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
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| Interaction |
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| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
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| Other map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02A OPIOIDS
N02AA Natural opium alkaloids
N02AA01 Morphine
D00842 Morphine sulfate (USP) <JP/US>
USP drug classification [BR:br08302]
Analgesics
Opioid Analgesics, Long-acting
Morphine
D00842 Morphine sulfate (USP)
Opioid Analgesics, Short-acting
Morphine
D00842 Morphine sulfate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
8 Narcotics
81 Alkaloidal narcotics
811 Opium alkaloids
8114 Morphines
D00842 Morphine sulfate (USP); Morphine sulfate hydrate (JP18)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00810 Morphine
D00842 Morphine sulfate
Analgesic
DG01984 Opioid analgesics
DG00810 Morphine
D00842 Morphine sulfate
Metabolizing enzyme substrate
DG02924 UGT substrate
DG00810 Morphine
D00842 Morphine sulfate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D00842 Morphine sulfate (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00842 Morphine sulfate hydrate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00842
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00810 Morphine
Analgesic
DG01984 Opioid analgesics
DG00810 Morphine
Metabolizing enzyme substrate
DG02924 UGT substrate
DG00810 Morphine
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| Other DBs |
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| KCF data |
ATOM 52
1 S4a S 29.2515 -20.6431
2 O1d O 29.2457 -19.2411
3 O1d O 29.2457 -22.0511
4 O1d O 27.8437 -20.6374
5 O1d O 30.6536 -20.6431
6 O0 O 30.0311 -24.2752
7 C1z C 18.8784 -23.6206
8 C8y C 18.8784 -22.2988
9 C1y C 20.0610 -24.3162
10 C1y C 17.7653 -24.2467
11 C1x C 20.0610 -22.9945
12 C8y C 17.7653 -21.6727
13 C8y C 20.0610 -21.6727
14 C1y C 21.1741 -23.6206
15 C2x C 20.0610 -25.5684
16 O2x O 16.4436 -22.9248
17 C1y C 17.7653 -25.5684
18 C1x C 22.2871 -22.9945
19 C8y C 17.7653 -20.3509
20 C1x C 21.1741 -22.3683
21 C8x C 20.0610 -20.3509
22 N1y N 22.2871 -24.3162
23 C2x C 18.8784 -26.2641
24 O1a O 16.6523 -26.2641
25 C8x C 18.9480 -19.7249
26 O1a O 16.6523 -19.7249
27 C1a C 23.6837 -24.3162
28 O0 O 30.0311 -24.2752
29 O0 O 30.0311 -24.2752
30 O0 O 30.0311 -24.2752
31 O0 O 30.0311 -24.2752
32 C1z C 18.8784 -23.6206
33 C8y C 18.8784 -22.2988
34 C8y C 17.7653 -21.6727
35 C8y C 17.7653 -20.3509
36 C8x C 18.9480 -19.7249
37 C8x C 20.0610 -20.3509
38 C8y C 20.0610 -21.6727
39 C1x C 21.1741 -22.3683
40 C1y C 21.1741 -23.6206
41 C1y C 20.0610 -24.3162
42 C2x C 20.0610 -25.5684
43 C2x C 18.8784 -26.2641
44 C1y C 17.7653 -25.5684
45 C1y C 17.7653 -24.2467
46 O2x O 16.4436 -22.9248
47 O1a O 16.6523 -26.2641
48 N1y N 22.2871 -24.3162
49 C1x C 22.2871 -22.9945
50 C1x C 20.0610 -22.9945
51 C1a C 23.6837 -24.3162
52 O1a O 16.6523 -19.7249
BOND 54
1 1 2 2
2 1 3 2
3 1 4 1
4 1 5 1
5 7 8 1
6 7 9 1
7 7 10 1
8 7 11 1 #Up
9 8 12 2
10 8 13 1
11 9 14 1
12 9 15 1
13 10 16 1 #Down
14 10 17 1
15 11 18 1
16 12 19 1
17 13 20 1
18 13 21 2
19 14 22 1 #Up
20 15 23 2
21 17 24 1 #Down
22 19 25 2
23 19 26 1
24 12 16 1
25 14 20 1
26 17 23 1
27 18 22 1
28 21 25 1
29 22 27 1
30 32 33 1
31 32 41 1
32 32 45 1
33 32 50 1 #Up
34 33 34 2
35 33 38 1
36 41 40 1
37 41 42 1
38 45 46 1 #Down
39 45 44 1
40 50 49 1
41 34 35 1
42 38 39 1
43 38 37 2
44 40 48 1 #Up
45 42 43 2
46 44 47 1 #Down
47 35 36 2
48 35 52 1
49 34 46 1
50 40 39 1
51 44 43 1
52 49 48 1
53 37 36 1
54 48 51 1
BRACKET 1 28.0700 -25.2700 28.0700 -23.2400
1 30.4500 -23.2400 30.4500 -25.2700
1 5
ORIGINAL 1 6
REPEAT 1 29 30 31 32
2 14.5600 -27.0200 14.5600 -18.6900
2 25.4800 -18.6900 25.4800 -27.0200
2 2
ORIGINAL 2 7 8 12 19 25 21 13 20 14 9 15 23 17 10 16 24
2 27 22 18 11 28 26
REPEAT 2 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48
2 49 50 51 52 53 54
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