Entry |
|
Name |
Abacavir sulfate (JAN/USP); Ziagen (TN) |
Product |
|
Generic |
ABACAVIR (American Health Packaging), ABACAVIR (Aurobindo Pharma Limited), ABACAVIR (Aurobindo Pharma Limited), ABACAVIR (AvPAK), ABACAVIR (Camber Pharmaceuticals), ABACAVIR (Camber Pharmaceuticals), ABACAVIR (Cipla USA), ABACAVIR (Major Pharmaceuticals), ABACAVIR (REMEDYREPACK), ABACAVIR (Rising Pharmaceuticals), ABACAVIR (Strides Pharma Science Limited), ABACAVIR (XLCare Pharmaceuticals), ABACAVIR SULFATE (Mylan Institutional), ABACAVIR SULFATE (Mylan Pharmaceuticals) |
Formula |
(C14H18N6O)2. H2SO4
|
Exact mass |
670.2758
|
Mol weight |
670.7431
|
Structure |
|
Class |
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
|
Remark |
Therapeutic category: | 6250 |
Product (DG00660): | D00891<JP/US> |
Product (mixture): | D08775<JP/US> D10600<JP/US> D10838<US> |
|
Efficacy |
Antiviral, Reverse transcriptase inhibitor |
Disease |
|
Target |
HIV-1 reverse transcriptase [KO: K24802] |
Pathway |
|
Interaction |
|
Structure map |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
J05AF06 Abacavir
D00891 Abacavir sulfate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Antivirals
Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)
Abacavir
D00891 Abacavir sulfate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
625 Antivirals
6250 Antivirals
D00891 Abacavir sulfate (JAN/USP)
Drug groups [BR:br08330]
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG00660 Abacavir
D00891 Abacavir sulfate
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
DG00660 Abacavir
D00891 Abacavir sulfate
Drug classes [BR:br08332]
Antiviral
DG03107 Anti-HIV agent
D00891 Abacavir sulfate
Antimicrobials [BR:br08307]
Antivirals
Genome replication inhibitor
HIV reverse transcriptase inhibitor
D00891 Abacavir sulfate (JAN/USP) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D00891
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00891
Drug groups [BR:br08330]
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG00660 Abacavir
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
DG00660 Abacavir
Antimicrobials abbreviations [BR:br08327]
Antivirals
Genome replication inhibitor
HIV reverse transcriptase inhibitor
DG00660 Abacavir
|
Other DBs |
|
KCF data |
ATOM 47
1 S4a S 33.1161 -16.8714
2 O1d O 31.7182 -16.8656
3 O1d O 34.5138 -16.8714
4 O1d O 33.1102 -15.4737
5 O1d O 33.1102 -18.2750
6 C8y C 23.3800 -16.8700
7 C8y C 23.3800 -18.3400
8 C8y C 24.5700 -16.1700
9 N5x N 22.1900 -16.3800
10 N4y N 22.1200 -18.7600
11 N5x N 24.5700 -19.1100
12 N1b N 24.5700 -14.8400
13 N5x N 25.8300 -16.9400
14 C8x C 21.3500 -17.5000
15 C1y C 21.0000 -19.6700
16 C8y C 25.8300 -18.4100
17 C1y C 25.8300 -14.1400
18 C1x C 19.8100 -18.9000
19 C2x C 20.5800 -21.0000
20 N1a N 27.0200 -19.1800
21 C1x C 27.2300 -14.2100
22 C1x C 26.5300 -12.9500
23 C1y C 18.7600 -19.6700
24 C2x C 19.2500 -21.0000
25 C1b C 17.4300 -19.3200
26 O1a O 16.3800 -20.1600
27 C8y C 23.3800 -16.8700
28 C8y C 23.3800 -18.3400
29 N4y N 22.1200 -18.7600
30 C1y C 21.0000 -19.6700
31 C1x C 19.8100 -18.9000
32 C1y C 18.7600 -19.6700
33 C1b C 17.4300 -19.3200
34 O1a O 16.3800 -20.1600
35 C2x C 19.2500 -21.0000
36 C2x C 20.5800 -21.0000
37 C8x C 21.3500 -17.5000
38 N5x N 22.1900 -16.3800
39 N5x N 24.5700 -19.1100
40 C8y C 25.8300 -18.4100
41 N1a N 27.0200 -19.1800
42 N5x N 25.8300 -16.9400
43 C8y C 24.5700 -16.1700
44 N1b N 24.5700 -14.8400
45 C1y C 25.8300 -14.1400
46 C1x C 27.2300 -14.2100
47 C1x C 26.5300 -12.9500
BOND 52
1 1 2 1
2 1 3 1
3 1 4 2
4 1 5 2
5 6 7 2
6 6 8 1
7 6 9 1
8 7 10 1
9 7 11 1
10 8 12 1
11 8 13 2
12 9 14 2
13 15 10 1 #Up
14 11 16 2
15 12 17 1
16 15 18 1
17 15 19 1
18 16 20 1
19 17 21 1
20 17 22 1
21 18 23 1
22 19 24 2
23 23 25 1 #Up
24 25 26 1
25 10 14 1
26 13 16 1
27 21 22 1
28 23 24 1
29 27 28 2
30 27 43 1
31 27 38 1
32 28 29 1
33 28 39 1
34 43 44 1
35 43 42 2
36 38 37 2
37 30 29 1 #Up
38 39 40 2
39 44 45 1
40 30 31 1
41 30 36 1
42 40 41 1
43 45 46 1
44 45 47 1
45 31 32 1
46 36 35 2
47 32 33 1 #Up
48 33 34 1
49 29 37 1
50 42 40 1
51 46 47 1
52 32 35 1
BRACKET 1 13.6500 -20.7200 13.6500 -13.1600
1 29.4000 -13.1600 29.4000 -20.7200
1 2
ORIGINAL 1 6 7 10 15 18 23 25 26 24 19 14 9 11 16 20 13
1 8 12 17 21 22
REPEAT 1 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
1 43 44 45 46 47
|