| Entry |
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| Name |
Fluvastatin sodium (JAN/USP);
Lescol (TN) |
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| Product |
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| Generic |
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| Formula |
C24H25FNO4. Na
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| Exact mass |
433.1665
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| Mol weight |
433.4478
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| Structure |
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| Simcomp |
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| Class |
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
Transporter substrate
DG02856 SLCO1B1 substrate
Transporter inhibitor
DG02882 ABCB11 inhibitor
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| Remark |
| Therapeutic category: | 2189 |
| Product (DG00354): | D00892<JP/US> |
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| Efficacy |
Antihyperlipidemic, HMG-CoA reductase inhibitor |
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| Disease |
Hypercholesterolemia (Heterozygous familial) [DS: H00155] Mixed dyslipidemia [DS: H01635] |
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| Target |
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| Pathway |
| hsa00900 | Terpenoid backbone biosynthesis |
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
Transporter: SLCO1B1 [HSA: 10599]
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| Interaction |
CYP inhibition: CYP2C9 [HSA: 1559]
Transporter inhibition: ABCB11 [HSA: 8647]
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AA HMG CoA reductase inhibitors
C10AA04 Fluvastatin
D00892 Fluvastatin sodium (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Dyslipidemics, HMG CoA Reductase Inhibitors
Fluvastatin
D00892 Fluvastatin sodium (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
218 Hyperlipidemia agents
2189 Others
D00892 Fluvastatin sodium (JAN/USP)
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
DG00354 Fluvastatin
D00892 Fluvastatin sodium
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00354 Fluvastatin
D00892 Fluvastatin sodium
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00354 Fluvastatin
D00892 Fluvastatin sodium
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG00354 Fluvastatin
D00892 Fluvastatin sodium
Transporter substrate
DG02856 SLCO1B1 substrate
DG00354 Fluvastatin
D00892 Fluvastatin sodium
Transporter inhibitor
DG02882 ABCB11 inhibitor
DG00354 Fluvastatin
D00892 Fluvastatin sodium
Drug classes [BR:br08332]
Cardiovascular agent
DG01946 Hypolipidemic agent
D00892 Fluvastatin sodium
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dehydrogenases
HMGCR
D00892 Fluvastatin sodium (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00892
Drug transporters
D00892
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
DG00354 Fluvastatin
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00354 Fluvastatin
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00354 Fluvastatin
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG00354 Fluvastatin
Transporter substrate
DG02856 SLCO1B1 substrate
DG00354 Fluvastatin
Transporter inhibitor
DG02882 ABCB11 inhibitor
DG00354 Fluvastatin
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| Other DBs |
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| KCF data |
ATOM 31
1 Z Na 25.8336 -11.8516 #+
2 C8y C 12.5783 -14.7270
3 C8x C 12.5783 -16.1297
4 C8x C 13.7706 -16.8311
5 C8y C 15.0330 -16.1297
6 C8x C 15.0330 -14.7270
7 C8x C 13.7706 -14.0257
8 X F 11.3861 -14.0257
9 C8y C 16.2253 -16.8311
10 C8y C 16.7162 -18.1636
11 C8y C 18.0488 -18.1636
12 N4y N 18.4696 -16.8311
13 C8y C 17.3474 -15.9895
14 C8x C 16.0149 -19.3559
15 C8x C 16.7162 -20.6183
16 C8x C 18.1189 -20.6183
17 C8x C 18.8203 -19.3559
18 C2b C 17.3474 -14.5868
19 C1a C 20.9243 -16.8311
20 C1c C 19.7320 -16.1297
21 C1a C 19.7320 -14.7270
22 C2b C 18.5397 -13.8854
23 C1c C 18.5397 -12.4828
24 C1b C 19.7320 -11.7814
25 C1c C 20.9243 -12.4828
26 C1b C 22.1165 -11.7814
27 C6a C 23.3088 -12.4828
28 O6a O 24.5011 -11.7814 #-
29 O6a O 23.3088 -13.8854
30 O1a O 17.3474 -11.7814
31 O1a O 20.9243 -13.8854
BOND 32
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 2 8 1
8 5 9 1
9 9 10 1
10 10 11 1
11 11 12 1
12 12 13 1
13 9 13 2
14 10 14 2
15 14 15 1
16 15 16 2
17 16 17 1
18 11 17 2
19 13 18 1
20 19 20 1
21 12 20 1
22 20 21 1
23 18 22 2
24 22 23 1
25 23 24 1
26 24 25 1
27 25 26 1
28 26 27 1
29 27 28 1
30 27 29 2
31 23 30 1 #Down
32 25 31 1 #Up
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