KEGG DRUG: Zanamivir

DRUG: Zanamivir

Entry

D00902                      Drug

Name

Zanamivir (USP/INN);
Relenza (TN)

Product

RELENZA (GlaxoSmithKline LLC)

Formula

C12H20N4O7

Exact mass

332.1332

Mol weight

332.3098

Structure

Simcomp

Class

Antiviral
DG03029 Anti-influenza virus agent
DG02842 Neuraminidase inhibitor

Remark

Same as:

C08095

ATC code:

J05AH01

Chemical structure group:

DG00664

Product (DG00664):

D00902<US> D01937<JP>

Efficacy

Antiviral, Neuraminidase inhibitor

Disease

Influenza [DS:H00398]

Target

Influenza A/B virus neuraminidase [KO:K19392]

Pathway

ko03230

Viral genome structure

ko05164

Influenza A

Structure map

map07044

Antiviral agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AH Neuraminidase inhibitors
     J05AH01 Zanamivir
      D00902  Zanamivir (USP/INN) <US>
USP drug classification [BR:br08302]
Antivirals
  Anti-influenza Agents
   Zanamivir
    D00902  Zanamivir (USP/INN)
Drug groups [BR:br08330]
Antiviral
  DG03029  Anti-influenza virus agent
   DG02842  Neuraminidase inhibitor
    DG00664  Zanamivir
     D00902  Zanamivir
Drug classes [BR:br08332]
Antiviral
  DG03029  Anti-influenza virus agent
   D00902  Zanamivir
Antimicrobials [BR:br08307]
Antivirals
  Virus release inhibitor
   Neuraminidase inhibitor
    D00902  Zanamivir (USP/INN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D00902
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D00902
Drug groups [BR:br08330]
Antiviral
  DG03029  Anti-influenza virus agent
   DG02842  Neuraminidase inhibitor
    DG00664  Zanamivir
Antimicrobials abbreviations [BR:br08327]
Antivirals
  Virus release inhibitor
   Neuraminidase inhibitor
    DG00664  Zanamivir

Other DBs

CAS:	139110-80-8

PubChem:

7847966

ChEBI:

50663

PDB-CCD:

ZMR[PDBj]

LigandBox:

D00902

NIKKAJI:

J621.505J J680.760G

KCF data

ATOM        23
            1   C2x C    23.0207  -17.2968
            2   C1y C    23.0207  -18.6980
            3   C1y C    24.2381  -19.4020
            4   C1y C    25.4412  -18.6980
            5   O2x O    25.4412  -17.2968
            6   C2y C    24.2381  -16.5997
            7   N1b N    21.8098  -19.4020
            8   C2c C    20.5986  -18.6980
            9   N1a N    19.3875  -19.4020
            10  N2a N    20.5986  -17.2968
            11  C6a C    24.2397  -15.1985
            12  O6a O    25.4480  -14.4960
            13  O6a O    23.0261  -14.4930
            14  N1b N    24.2397  -21.2232
            15  C5a C    23.0261  -21.9218
            16  C1a C    23.0280  -23.3230
            17  C1c C    26.6469  -19.3949
            18  C1c C    27.8579  -18.6909
            19  C1b C    29.0690  -19.3878
            20  O1a O    30.2801  -18.6838
            21  O1a O    27.8548  -17.2897
            22  O1a O    26.6486  -20.7961
            23  O5a O    21.8111  -21.2262
BOND        23
            1    11  12 1
            2     5   6 1
            3    11  13 2
            4     6   1 2
            5     3  14 1 #Down
            6    14  15 1
            7     2   7 1 #Up
            8    15  16 1
            9     7   8 1
            10    4  17 1
            11    1   2 1
            12   17  18 1
            13    8   9 1
            14   18  19 1
            15    2   3 1
            16   19  20 1
            17    8  10 2
            18   18  21 1 #Down
            19    3   4 1
            20   17  22 1 #Up
            21    6  11 1
            22   15  23 2
            23    4   5 1

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