KEGG   DRUG: Diclofenac sodium
Entry
D00904                      Drug                                   
Name
Diclofenac sodium (JP18/USP);
Solaraze (TN);
Voltaren (TN)
Product
PENNSAID (Horizon Therapeutics USA), VOLTAREN (Proficient Rx LP)
  Generic
DICLOFENAC (Advanced Rx Pharmacy of Tennessee), DICLOFENAC (Altaire Pharmaceuticals), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (Actavis Pharma), DICLOFENAC SODIUM (Actavis Pharma), DICLOFENAC SODIUM (Advagen Pharma), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Advanced Rx Pharmacy of Tennessee), DICLOFENAC SODIUM (Alembic Pharmaceuticals), DICLOFENAC SODIUM (Alembic Pharmaceuticals), DICLOFENAC SODIUM (American Health Packaging), DICLOFENAC SODIUM (American Health Packaging), DICLOFENAC SODIUM (Amneal Pharmaceuticals LLC), DICLOFENAC SODIUM (Amneal Pharmaceuticals LLC), DICLOFENAC SODIUM (Amneal Pharmaceuticals LLC), DICLOFENAC SODIUM (Aphena Pharma Solutions - Tennessee), DICLOFENAC SODIUM (Apotex Corp.), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Asclemed USA), DICLOFENAC SODIUM (Aurolife Pharma LLC), DICLOFENAC SODIUM (AvKARE), DICLOFENAC SODIUM (AvKARE), DICLOFENAC SODIUM (Bausch & Lomb Incorporated), DICLOFENAC SODIUM (BluePoint Laboratories), DICLOFENAC SODIUM (BluePoint Laboratories), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Carlsbad Technology), DICLOFENAC SODIUM (Cipla USA), DICLOFENAC SODIUM (DIRECT RX), DICLOFENAC SODIUM (DIRECTRX), DICLOFENAC SODIUM (Denton Pharma), DICLOFENAC SODIUM (Denton Pharma), DICLOFENAC SODIUM (DirectRx), DICLOFENAC SODIUM (Direct_Rx), DICLOFENAC SODIUM (Direct_Rx), DICLOFENAC SODIUM (EXELAN PHARMACEUTICALS), DICLOFENAC SODIUM (Edenbridge Pharmaceuticals LLC.), DICLOFENAC SODIUM (Encube Ethicals Private Limited), DICLOFENAC SODIUM (GLENMARK PHARMACEUTICALS), DICLOFENAC SODIUM (Gabar Health Sciences Corp), DICLOFENAC SODIUM (Golden State Medical Supply), DICLOFENAC SODIUM (IPG PHARMACEUTICALS), DICLOFENAC SODIUM (IPG PHARMACEUTICALS), DICLOFENAC SODIUM (Ingenus Pharmaceuticals), DICLOFENAC SODIUM (Lake Erie Medical DBA Quality Care Products LLC), DICLOFENAC SODIUM (Lannett Company), DICLOFENAC SODIUM (Lupin Pharmaceuticals), DICLOFENAC SODIUM (Lupin Pharmaceuticals), DICLOFENAC SODIUM (Lupin Pharmaceuticals), DICLOFENAC SODIUM (Lupin Pharmaceuticals), DICLOFENAC SODIUM (Medsource Pharmaceuticals), DICLOFENAC SODIUM (Medsource Pharmaceuticals), DICLOFENAC SODIUM (Medsource Pharmaceuticals), DICLOFENAC SODIUM (Medsource Pharmaceuticals), DICLOFENAC SODIUM (Medsource pharmaceuticals), DICLOFENAC SODIUM (NORTHWIND PHARMACEUTICALS), DICLOFENAC SODIUM (Northwind Pharmaceuticals), DICLOFENAC SODIUM (Novel Laboratories), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (NuCare Pharmaceuticals), DICLOFENAC SODIUM (Oceanside Pharmaceuticals), DICLOFENAC SODIUM (PD-Rx Pharmaceuticals), DICLOFENAC SODIUM (PD-Rx Pharmaceuticals), DICLOFENAC SODIUM (Padagis Israel Pharmaceuticals), DICLOFENAC SODIUM (Padagis Israel Pharmaceuticals), DICLOFENAC SODIUM (Padagis US LLC), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (PureTek Corporation), DICLOFENAC SODIUM (PureTek Corporation), DICLOFENAC SODIUM (Quality Care Products LLC), DICLOFENAC SODIUM (Quality Care Products LLC), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (Quality Care Products), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REPHARM LLC), DICLOFENAC SODIUM (RPK Pharmaceuticals), DICLOFENAC SODIUM (RPK Pharmaceuticals), DICLOFENAC SODIUM (RPK Pharmaceuticals), DICLOFENAC SODIUM (RPK Pharmaceuticals), DICLOFENAC SODIUM (RedPharm Drug), DICLOFENAC SODIUM (RedPharm Drug), DICLOFENAC SODIUM (Rising Pharma Holdings), DICLOFENAC SODIUM (Rising Pharmaceuticals), DICLOFENAC SODIUM (SOLA Pharmaceuticals), DICLOFENAC SODIUM (Sandoz), DICLOFENAC SODIUM (St. Mary's Medical Park Pharmacy), DICLOFENAC SODIUM (St. Mary's Medical Park Pharmacy), DICLOFENAC SODIUM (St. Mary's Medical Park Pharmacy), DICLOFENAC SODIUM (St. Mary's Medical Park Pharmacy), DICLOFENAC SODIUM (St. Mary's Medical Park Pharmacy), DICLOFENAC SODIUM (Taro Pharmaceuticals U.S.A.), DICLOFENAC SODIUM (Taro Pharmaceuticals U.S.A.), DICLOFENAC SODIUM (Taro Pharmaceuticals U.S.A.), DICLOFENAC SODIUM (UNIT DOSE SERVICES), DICLOFENAC SODIUM (UNIT DOSE SERVICES), DICLOFENAC SODIUM (UNIT DOSE SERVICES.), DICLOFENAC SODIUM (UNIT DOSE SERVICES.), DICLOFENAC SODIUM (Viona Pharmaceuticals), DICLOFENAC SODIUM (Zydus Lifesciences Limited), DICLOFENAC SODIUM (medsource pharmaceuticals), DICLOFENAC SODIUM (medsource pharmaceuticals), DICLOFENAC SODIUM (medsource pharmaceuticals), DICLOFENAC SODIUM 1.5% (Preferred Pharmaceuticals), DICLOFENAC SODIUM 1.5% (Proficient Rx LP), DICLOFENAC SODIUM 1.5% (Proficient Rx LP), DICLOFENAC SODIUM 1.5% (Quality Care Products), DICLOFENAC SODIUM 1.5% (SOLA Pharmaceuticals), DICLOFENAC SODIUM D/R (Direct RX), DICLOFENAC SODIUM DELAYED RELEASE (A-S Medication Solutions), DICLOFENAC SODIUM DELAYED RELEASE (Cambridge Therapeutics Technologies), DICLOFENAC SODIUM GEL (Direct_Rx), DICLOFENAC SODIUM GEL (Direct_Rx), DICLOFENAC SODIUM GEL (Direct_Rx), DICLOFENAC SODIUM TOPICAL SOL (Direct_Rx), DICLOFENAC SODIUM TOPICAL SOLUTION (Direct_Rx), DICLOFENAC SODIUM TOPICAL SOLUTION (Direct_Rx), DICLOFENAC SODIUM TOPICAL SOLUTION (medsource pharmaceuticals), INFLATHERM (V2 Pharma), NUDICLO SOLUPAK (NuCare Pharmaceuticals), NUDICLO TABPAK (Nucare Pharmaceuticals), VAROPHEN (V2 Pharma), VOLTAREN (Direct_Rx)
Formula
C14H10Cl2NO2. Na
Exact mass
316.9986
Mol weight
318.1305
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01906  Anti-inflammatory drug, acetic acid derivatives
   DG01898  Anti-inflammatory drug, phenylacetic acid derivatives
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Transporter inhibitor
 DG02866  SLC22A8 inhibitor
Remark
Therapeutic category: 1147 1319 2649
ATC code: D11AX18 M01AB05 M02AA15 S01BC03
Chemical structure group: DG00441
Product (DG00441): D00903<US> D00904<JP/US> D07818<US>
Product (mixture): D11091<US>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Transporter inhibition: SLC22A8 [HSA:9376]
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX18 Diclofenac
      D00904  Diclofenac sodium (JP18/USP) <JP/US>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AB Acetic acid derivatives and related substances
     M01AB05 Diclofenac
      D00904  Diclofenac sodium (JP18/USP) <JP/US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA15 Diclofenac
      D00904  Diclofenac sodium (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC03 Diclofenac
      D00904  Diclofenac sodium (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Diclofenac
    D00904  Diclofenac sodium (JP18/USP)
 Dermatological Agents
  Dermatological Agents, Other
   Warts and Actinic Keratosis Agents
    Diclofenac
     D00904  Diclofenac sodium (JP18/USP)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Nonsteroidal Anti-Inflammatory Drugs, Ophthalmic
    Diclofenac
     D00904  Diclofenac sodium (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1147  Phenylacetates
     D00904  Diclofenac sodium (JP18/USP)
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00904  Diclofenac sodium (JP18/USP)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00904  Diclofenac sodium (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00904  Diclofenac sodium (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Diclofenac
    D00904  Diclofenac sodium (JP18/USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01906  Anti-inflammatory drug, acetic acid derivatives
    DG01898  Anti-inflammatory drug, phenylacetic acid derivatives
     DG00441  Diclofenac
      D00904  Diclofenac sodium
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   DG00441  Diclofenac
    D00904  Diclofenac sodium
 Transporter inhibitor
  DG02866  SLC22A8 inhibitor
   DG00441  Diclofenac
    D00904  Diclofenac sodium
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D00904  Diclofenac sodium
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00904  Diclofenac sodium (JP18/USP) <JP/US>
    PTGS2 (COX2)
     D00904  Diclofenac sodium (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00904  Diclofenac sodium
  D00904  Diclofenac sodium suppositories
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00904
 Drug transporters
  D00904
Rx-to-OTC switch list in the USA [br08315.html]
 D00904
Rx-to-OTC switch list in Japan [br08314.html]
 D00904
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01906  Anti-inflammatory drug, acetic acid derivatives
    DG01898  Anti-inflammatory drug, phenylacetic acid derivatives
     DG00441  Diclofenac
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   DG00441  Diclofenac
 Transporter inhibitor
  DG02866  SLC22A8 inhibitor
   DG00441  Diclofenac
Other DBs
CAS: 15307-79-6
PubChem: 7847968
ChEBI: 4509
LigandBox: D00904
NIKKAJI: J8.556A
KCF data

ATOM        20
            1   Z   Na   34.1141  -25.5138 #+
            2   C8x C    26.2972  -26.1573
            3   C8x C    26.2972  -27.5565
            4   C8x C    27.5089  -28.2561
            5   C8x C    28.7206  -27.5565
            6   C8y C    28.7206  -26.1573
            7   C8y C    27.5089  -25.4578
            8   C1b C    29.9510  -25.4468
            9   C6a C    31.1554  -26.1420
            10  O6a O    32.3370  -25.4597 #-
            11  O6a O    31.1558  -27.5561
            12  N1b N    27.5089  -24.0588
            13  C8y C    26.2804  -23.3494
            14  C8y C    26.2807  -21.9600
            15  C8x C    25.0692  -21.2602
            16  C8x C    23.8573  -21.9595
            17  C8x C    23.8570  -23.3489
            18  C8y C    25.0686  -24.0487
            19  X   Cl   27.5049  -21.2534
            20  X   Cl   25.0686  -25.4575
BOND        20
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     6   8 1
            8     8   9 1
            9     9  10 1
            10    9  11 2
            11    7  12 1
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   16  17 1
            17   17  18 2
            18   13  18 1
            19   14  19 1
            20   18  20 1

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Ontology (12)   
   KEGG BRITE (12)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (8)   
   PubChem (1)   
   ChEBI (1)   
   MASSBANK (5)   
   NIKKAJI (1)   
Gene (4)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (2)   
All databases (28)   

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