| Entry |
|
|---|
| Name |
Paricalcitol (JAN/USP/INN);
Zemplar (TN) |
|---|
| Product |
|
|---|
| Generic |
PARICALCITOL (Amneal Pharmaceuticals LLC), PARICALCITOL (Amneal Pharmaceuticals LLC), PARICALCITOL (Aurobindo Pharma Limited), PARICALCITOL (Bionpharma), PARICALCITOL (Bryant Ranch Prepack), PARICALCITOL (Bryant Ranch Prepack), PARICALCITOL (Bryant Ranch Prepack), PARICALCITOL (Bryant Ranch Prepack), PARICALCITOL (Dr. Reddy's Laboratories Limited), PARICALCITOL (Dr. Reddy's Laboratories), PARICALCITOL (Eugia US LLC), PARICALCITOL (MARKSANS PHARMA LIMITED), PARICALCITOL (TIME CAP LABORATORIES) |
|---|
| Formula |
C27H44O3
|
|---|
| Exact mass |
416.329
|
|---|
| Mol weight |
416.6365
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Gastrointestinal agent
DG01607 Vitamin D derivatives
|
|---|
| Remark |
|
|---|
| Efficacy |
Antihyperparathyroidism, Vitamin D receptor agonist |
|---|
| Disease |
Secondary hyperparathyroidism [DS: H01669] |
|---|
| Comment |
Vitamin D analog
Treatment of osteodystrophy (for the reduction of parathyroid hormone levels)
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04928 | Parathyroid hormone synthesis, secretion and action |
| hsa04961 | Endocrine and other factor-regulated calcium reabsorption |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H05 CALCIUM HOMEOSTASIS
H05B ANTI-PARATHYROID AGENTS
H05BX Other anti-parathyroid agents
H05BX02 Paricalcitol
D00930 Paricalcitol (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
Metabolic Bone Disease Agents
Vitamin D-related Agents
Paricalcitol
D00930 Paricalcitol (JAN/USP/INN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01607 Vitamin D derivatives
D00930 Paricalcitol
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Thyroid hormone like receptors
Vitamin D3 like receptor
NR1I1 (VDR)
D00930 Paricalcitol (JAN/USP/INN) <US>
|
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| Other DBs |
|
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| KCF data |
ATOM 30
1 C1x C 14.1400 -22.7500
2 C1x C 14.1400 -24.1500
3 C2y C 15.3524 -24.8500
4 C1y C 16.5649 -24.1500
5 C1z C 16.5649 -22.7500
6 C1x C 15.3524 -22.0500
7 C1x C 17.8964 -24.5826
8 C1x C 18.7193 -23.4500
9 C1y C 17.8964 -22.3174
10 C1a C 16.5649 -21.3500
11 C2b C 15.3524 -26.2498
12 C2b C 14.1232 -26.9597
13 C2y C 14.1234 -28.3499
14 C1x C 12.9235 -29.0430
15 C1y C 12.9238 -30.4430
16 C1x C 14.1364 -31.1427
17 C1y C 15.3363 -30.4496
18 C1x C 15.3360 -29.0496
19 O1a O 16.5443 -31.1468
20 O1a O 11.7284 -31.1338
21 C1c C 18.3275 -20.9906
22 C2b C 19.7275 -20.9906
23 C1a C 17.5135 -19.8700
24 C2b C 20.4266 -19.7799
25 C1c C 21.8397 -19.7797
26 C1a C 22.5533 -21.0147
27 C1d C 22.5265 -18.5899
28 O1a O 23.9397 -18.5895
29 C1a C 21.8427 -17.4060
30 C1a C 23.2432 -19.8306
BOND 32
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 5 9 1
11 5 10 1 #Up
12 3 11 2
13 11 12 1
14 12 13 2
15 13 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 13 18 1
21 17 19 1 #Up
22 15 20 1 #Down
23 9 21 1
24 21 22 1
25 21 23 1 #Down
26 22 24 2
27 24 25 1
28 25 26 1 #Up
29 25 27 1
30 27 28 1
31 27 29 1
32 27 30 1
|
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