| Entry |
|
|---|
| Name |
Anastrozole (JP18/USP/INN);
Arimidex (TN) |
|---|
| Product |
|
|---|
| Generic |
ANASTROZOLE (A-S Medication Solutions), ANASTROZOLE (A-S Medication Solutions), ANASTROZOLE (Accord Healthcare), ANASTROZOLE (American Health Packaging), ANASTROZOLE (Asclemed USA), ANASTROZOLE (Aurobindo Pharma Limited), ANASTROZOLE (AvKARE), ANASTROZOLE (AvKARE), ANASTROZOLE (AvPAK), ANASTROZOLE (Avet Pharmaceuticals), ANASTROZOLE (BluePoint Laboratories), ANASTROZOLE (Breckenridge Pharmaceutical), ANASTROZOLE (Bryant Ranch Prepack), ANASTROZOLE (Bryant Ranch Prepack), ANASTROZOLE (Chartwell RX), ANASTROZOLE (Direct_Rx), ANASTROZOLE (Major Pharmaceuticals), ANASTROZOLE (Natco Pharma Limited), ANASTROZOLE (NuCare Pharmaceuticals), ANASTROZOLE (NuCare Pharmaceuticals), ANASTROZOLE (NuCare Pharmaceuticals), ANASTROZOLE (PD-Rx Pharmaceuticals), ANASTROZOLE (PD-Rx Pharmaceuticals), ANASTROZOLE (PD-Rx Pharmaceuticals), ANASTROZOLE (Proficient Rx LP), ANASTROZOLE (Teva Pharmaceuticals USA), ANASTROZOLE (Yiling Pharmaceutical), ANASTROZOLE (Zydus Lifesciences Limited), ANASTROZOLE (Zydus Pharmaceuticals USA) |
|---|
| Formula |
C17H19N5
|
|---|
| Exact mass |
293.164
|
|---|
| Mol weight |
293.3663
|
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| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antineoplastic
DG01596 Aromatase inhibitor
DG01524 Triazole antineoplastic
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
DG01643 CYP2C9 inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
|
|---|
| Remark |
| Therapeutic category: | 4291 |
|
|---|
| Efficacy |
Antineoplastic, Estrogen biosynthesis inhibitor |
|---|
| Disease |
Breast cancer, postmenopausal (HR-positive or HR-unknown) [DS: H00031] |
|---|
| Comment |
Aromatase inhibitor
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
CYP inhibition: CYP1A2 [HSA: 1544], CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
|
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| Structure map |
|
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| Other map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L02 ENDOCRINE THERAPY
L02B HORMONE ANTAGONISTS AND RELATED AGENTS
L02BG Aromatase inhibitors
L02BG03 Anastrozole
D00960 Anastrozole (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
Aromatase Inhibitors
Anastrozole
D00960 Anastrozole (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
429 Miscellaneous
4291 Other Antitumors
D00960 Anastrozole (JP18/USP/INN)
Drug groups [BR:br08330]
Antineoplastic
DG01596 Aromatase inhibitor
D00960 Anastrozole
DG01524 Triazole antineoplastic
D00960 Anastrozole
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
D00960 Anastrozole
DG01643 CYP2C9 inhibitor
D00960 Anastrozole
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
D00960 Anastrozole
Drug classes [BR:br08332]
Antineoplastic
DG01596 Aromatase inhibitor
D00960 Anastrozole
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Cytochrome P450
CYP19A1 (ARO)
D00960 Anastrozole (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00960 Anastrozole
D00960 Anastrozole tablets
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00960
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00960
Pharmacogenomic biomarkers [br08341.html]
Somatic variations in targeted cancer therapies
D00960
|
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| Other DBs |
|
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| KCF data |
ATOM 22
1 C8x C 8.8900 -10.7800
2 C8y C 8.8900 -12.1800
3 C8x C 10.1024 -12.8800
4 C8y C 11.3149 -12.1800
5 C8x C 11.3149 -10.7800
6 C8y C 10.1024 -10.0800
7 C1b C 10.1024 -8.6802
8 N4y N 11.2980 -7.9898
9 C1d C 7.6776 -12.8800
10 C1d C 12.5460 -12.8910
11 C3b C 13.7584 -13.5910
12 C1a C 11.8467 -14.1019
13 C1a C 13.2468 -11.6774
14 N3a N 14.9709 -14.2910
15 C3b C 6.4651 -13.5800
16 C1a C 6.9834 -11.6773
17 C1a C 8.3830 -14.1021
18 N3a N 5.2527 -14.2800
19 N5x N 12.6279 -8.4272
20 C8x C 13.4536 -7.2966
21 N5x N 12.6335 -6.1620
22 C8x C 11.3009 -6.5913
BOND 23
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 6 7 1
8 7 8 1
9 2 9 1
10 4 10 1
11 10 11 1
12 10 12 1
13 10 13 1
14 11 14 3
15 9 15 1
16 9 16 1
17 9 17 1
18 15 18 3
19 8 19 1
20 19 20 2
21 20 21 1
22 21 22 2
23 8 22 1
|
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