KEGG   DRUG: Meloxicam
Entry
D00969                      Drug                                   
Name
Meloxicam (JAN/USP/INN);
Mobic (TN)
Product
MELOXICAM (Avondale Pharmaceuticals)
  Generic
MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (Advanced Rx Pharmacy of Tennessee), MELOXICAM (Advanced Rx Pharmacy of Tennessee), MELOXICAM (Advanced Rx Pharmacy of Tennessee), MELOXICAM (Advanced Rx Pharmacy of Tennessee), MELOXICAM (Advanced Rx Pharmacy of Tennessee), MELOXICAM (Advanced Rx Pharmacy of Tennessee), MELOXICAM (AiPing Pharmaceutical), MELOXICAM (American Health Packaging), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Ascent Pharmaceuticals), MELOXICAM (Asclemed USA), MELOXICAM (Asclemed USA), MELOXICAM (Aurobindo Pharma Limited), MELOXICAM (AvPAK), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Camber Pharmaceuticals), MELOXICAM (Carlsbad Technology), MELOXICAM (Chartwell RX), MELOXICAM (Cipla USA), MELOXICAM (Denton Pharma), MELOXICAM (Denton Pharma), MELOXICAM (Direct Rx), MELOXICAM (Direct_Rx), MELOXICAM (Direct_Rx), MELOXICAM (Direct_Rx), MELOXICAM (Emerald Therapeutics), MELOXICAM (Exelan Pharmaceuticals), MELOXICAM (Glenmark Pharmaceuticals), MELOXICAM (Golden State Medical Supply), MELOXICAM (Lupin Pharmaceuticals), MELOXICAM (Lupin Pharmaceuticals), MELOXICAM (Medsource Pharmaceuticals), MELOXICAM (NCS HealthCare of KY), MELOXICAM (Northwind Pharmaceuticals), MELOXICAM (Northwind Pharmaceuticals), MELOXICAM (Northwind Pharmaceuticals), MELOXICAM (Northwind Pharmaceuticals), MELOXICAM (Novitium Pharma LLC), MELOXICAM (NuCare Pharmaceuticals), MELOXICAM (NuCare Pharmaceuticals), MELOXICAM (NuCare Pharmaceuticals), MELOXICAM (NuCare Pharmaceuticals), MELOXICAM (PD-Rx Pharmaceuticals), MELOXICAM (PD-Rx Pharmaceuticals), MELOXICAM (PD-Rx Pharmaceuticals), MELOXICAM (PD-Rx Pharmaceuticals), MELOXICAM (Preferred Pharmaceuticals), MELOXICAM (Preferred Pharmaceuticals), MELOXICAM (Proficient Rx LP), MELOXICAM (Proficient Rx LP), MELOXICAM (Proficient Rx LP), MELOXICAM (QPharma), MELOXICAM (QPharma), MELOXICAM (Quality Care Products LLC), MELOXICAM (Quality Care Products LLC), MELOXICAM (Quallent Pharmaceuticals Health LLC), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (RPK Pharmaceuticals), MELOXICAM (RPK Pharmaceuticals), MELOXICAM (RedPharm Drug), MELOXICAM (Redpharm Drug), MELOXICAM (Rising Pharma Holdings), MELOXICAM (ST. MARY'S MEDICAL PARK PHARMACY), MELOXICAM (St. Mary's Medical Park Pharmacy), MELOXICAM (St. Mary's Medical Park Pharmacy), MELOXICAM (St. Mary's Medical Park Pharmacy), MELOXICAM (Strides Pharma Science Limited), MELOXICAM (Unichem Pharmaceuticals (USA)), MELOXICAM (XLCare Pharmaceuticals), MELOXICAM (Zydus Lifesciences Limited), MELOXICAM (Zydus Pharmaceuticals USA)
Formula
C14H13N3O4S2
Exact mass
351.0347
Mol weight
351.4007
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01910  Anti-inflammatory drug, oxicams
  DG01922  Selective COX2 inhibitor
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C08169
Therapeutic category: 1149
ATC code: M01AC06
Product: D00969<JP/US>
Product (mixture): D12270<US>
Efficacy
Analgesic, Anti-inflammatory, COX-2 inhibitor
Comment
Oxicams
Target
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]; CYP3A4 [HSA:1576]
Interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AC Oxicams
     M01AC06 Meloxicam
      D00969  Meloxicam (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Meloxicam
    D00969  Meloxicam (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00969  Meloxicam (JAN/USP/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01910  Anti-inflammatory drug, oxicams
    D00969  Meloxicam
   DG01922  Selective COX2 inhibitor
    D00969  Meloxicam
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   D00969  Meloxicam
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00969  Meloxicam
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D00969  Meloxicam
   D00969  Meloxicam
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS2 (COX2)
     D00969  Meloxicam (JAN/USP/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D00969
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00969
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00969
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00969
Other DBs
CAS: 71125-38-7
PubChem: 7848032
ChEBI: 6741
PDB-CCD: MXM[PDBj]
LigandBox: D00969
NIKKAJI: J22.773K
KCF data

ATOM        23
            1   C8y C    29.1386  -17.3775
            2   C8y C    29.1152  -18.7625
            3   C8y C    30.3483  -16.6996
            4   C8x C    27.9406  -16.6586
            5   S2x S    30.3015  -19.4695
            6   C8x C    27.9055  -19.4403
            7   C8y C    31.5345  -17.4125
            8   O1a O    30.3717  -15.3088
            9   C8x C    26.7310  -17.3481
            10  N4y N    31.5112  -18.7975
            11  O3c O    31.3591  -20.4571
            12  O3c O    29.1211  -20.5273
            13  C8x C    26.7135  -18.7391
            14  C5a C    32.7500  -16.7347
            15  C1a C    32.7149  -19.5105
            16  N1b N    33.9480  -17.4534
            17  O5a O    32.7734  -15.3438
            18  C8y C    35.1635  -16.7755
            19  N5x N    36.4943  -17.1641
            20  S2x S    35.1230  -15.3776
            21  C8x C    37.2806  -16.0189
            22  C8y C    36.4368  -14.9158
            23  C1a C    36.8219  -13.5763
BOND        25
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 2
            11    5  12 2
            12    6  13 2
            13    7  14 1
            14   10  15 1
            15   14  16 1
            16   14  17 2
            17   16  18 1
            18   18  19 2
            19   18  20 1
            20   19  21 1
            21   20  22 1
            22   22  23 1
            23    7  10 1
            24    9  13 1
            25   21  22 2

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