KEGG   DRUG: Prednisolone sodium phosphate
Entry
D00981                      Drug                                   
Name
Prednisolone sodium phosphate (JP18/USP);
Pediapred (TN)
Product
  Generic
Formula
C21H27O8P. 2Na
Exact mass
484.1239
Mol weight
484.3876
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Therapeutic category: 2456
ATC code: A01AC04 A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Product (mixture): D11699<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Atopic dermatitis [DS:H01358]
Allergic rhinitis [DS:H01360]
Bullous dermatitis herpetiformis [DS:H01362]
Contact dermatitis [DS:H01357]
Mycosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Severe erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Congenital adrenal hyperplasia [DS:H00216]
Primary or secondary adrenocortical insufficiency [DS:H01598]
Crohn's disease [DS:H00286]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Diamond-Blackfan anemia [DS:H00237]
Pure red cell aplasia [DS:H01586]
Multiple sclerosis [DS:H01490]
Acute or chronic solid organ rejection [DS:H00083]
Chronic obstructive pulmonary disease [DS:H01714]
Allergic bronchopulmonary aspergillosis [DS:H01328]
Asthma [DS:H00079]
Pulmonary tuberculosis [DS:H00342]
Hypersensitivity pneumonitis [DS:H00346]
Idiopathic bronchiolitis obliterans [DS:H01873]
Idiopathic pulmonary fibrosis [DS:H01299]
Pneumocystis carinii pneumonia [DS:H01521]
Nephrotic syndrome [DS:H01657]
Ankylosing spondylitis [DS:H01674]
Dermatomyositis and polymyositis [DS:H01604]
Polymyalgia rheumatica [DS:H01606]
Temporal arteritis [DS:H01698]
Psoriatic arthritis [DS:H01507]
Relapsing polychondritis [DS:H01758]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Sjogren's Syndrome [DS:H01502]
Systemic lupus erythematosus [DS:H00080]
Trichinosis with neurologic or myocardial involvement [DS:H01099]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC04 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Prednisolone
   D00981  Prednisolone sodium phosphate (JP18/USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Prednisolone
    D00981  Prednisolone sodium phosphate (JP18/USP)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Prednisolone
     D00981  Prednisolone sodium phosphate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2456  Prednisolones
     D00981  Prednisolone sodium phosphate (JP18/USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
     D00981  Prednisolone sodium phosphate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D00981  Prednisolone sodium phosphate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00981  Prednisolone sodium phosphate
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
Other DBs
CAS: 125-02-0
PubChem: 7848044
ChEBI: 8379
LigandBox: D00981
NIKKAJI: J5.364C
KCF data

ATOM        32
            1   C2x C     3.4829  -12.1384
            2   C5x C     3.4829  -13.5014
            3   C2x C     4.6633  -14.1829
            4   C2y C     5.8437  -13.5014
            5   C1z C     5.8437  -12.1384
            6   C2x C     4.6633  -11.4568
            7   C1x C     7.0241  -14.1829
            8   C1x C     8.2045  -13.5014
            9   C1y C     8.2045  -12.1384
            10  C1y C     7.0241  -11.4568
            11  C1y C     9.3850  -11.4568
            12  C1z C     9.3850  -10.0938
            13  C1x C     8.2045   -9.4123
            14  C1y C     7.0241  -10.0938
            15  C1x C    11.7457  -11.4568
            16  C1x C    11.7457  -10.0938
            17  C1z C    10.5654   -9.4123
            18  O5x O     2.3025  -14.1829
            19  C1a C     5.8437  -10.7753
            20  O1a O     5.8457   -9.4135
            21  C1a C     9.3850   -8.7308
            22  C5a C    10.5654   -7.6348
            23  O1a O    11.7457   -8.7308
            24  C1b C    11.7497   -6.9511
            25  O5a O     9.3889   -6.9555
            26  O2b O    12.9156   -7.6243
            27  P1b P    14.1511   -6.9106
            28  O1c O    15.3635   -6.2106 #-
            29  O1c O    13.4565   -5.7082 #-
            30  O1c O    14.8569   -8.1325
            31  Z   Na   11.1300   -5.6700 #+
            32  Z   Na   17.5700   -6.0200 #+
BOND        33
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   22  24 1
            28   22  25 2
            29   24  26 1
            30   26  27 1
            31   27  28 1
            32   27  29 1
            33   27  30 2

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