| Entry |
|
|---|
| Name |
Leuprolide acetate (USP);
Leuprorelin acetate (JP18);
Lupron (TN);
Lutrate (TN);
Eligard (TN);
Fensolvi (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C59H84N16O12. C2H4O2
|
|---|
| Exact mass |
1268.6666
|
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| Mol weight |
1269.4502
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Hormonal agent
DG01494 Gonadotropin-releasing hormone receptor agonist
|
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| Remark |
| Therapeutic category: | 2499 |
| Product (DG00730): | D00989<JP/US> D12337<US> |
|
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| Efficacy |
Antineoplastic, Gonadotropin-releasing hormone receptor agonist |
|---|
| Disease |
Endometriosis [DS: H01639] Uterine leiomyomata [DS: H01640] Central precocious puberty [DS: H02018] Prostate cancer [DS: H00024] |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Interaction |
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L02 ENDOCRINE THERAPY
L02A HORMONES AND RELATED AGENTS
L02AE Gonadotropin releasing hormone analogues
L02AE02 Leuprorelin
D00989 Leuprolide acetate (USP) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
Antineoplastics, Other
Leuprolide
D00989 Leuprolide acetate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
249 Miscellaneous
2499 Others
D00989 Leuprolide acetate (USP); Leuprorelin acetate (JP18)
Drug groups [BR:br08330]
Hormonal agent
DG01494 Gonadotropin-releasing hormone receptor agonist
DG00730 Leuprorelin
D00989 Leuprolide acetate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Gonadotropin-releasing hormone
GNRHR
D00989 Leuprolide acetate (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00989 Leuprorelin acetate
Drug groups [BR:br08330]
Hormonal agent
DG01494 Gonadotropin-releasing hormone receptor agonist
DG00730 Leuprorelin
|
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| Other DBs |
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| KCF data |
ATOM 91
1 C6a C 23.3263 -21.2463
2 C1a C 22.1044 -21.9542
3 O6a O 24.5383 -21.9443
4 O6a O 23.3164 -19.8402
5 C1c C 19.2124 -15.3004
6 N1b N 18.0037 -15.9403
7 C5a C 20.4211 -15.9403
8 C5a C 16.7951 -15.3004
9 N1b N 21.5587 -15.2293
10 O5a O 20.4211 -17.2911
11 C1c C 15.5864 -16.0114
12 O5a O 16.7951 -13.8784
13 C1c C 22.7673 -15.8692
14 N1b N 14.3777 -15.3004
15 C5a C 23.9760 -15.2293
16 C5a C 13.1691 -16.0114
17 N1b N 25.1847 -15.8692
18 O5a O 23.9760 -13.8073
19 C1y C 11.9604 -15.3715
20 O5a O 13.1691 -17.4333
21 C1c C 26.3933 -15.1582
22 C1x C 10.6806 -15.7981
23 N1x N 11.9604 -13.9495
24 C1b C 26.3933 -13.8073
25 C5a C 27.6020 -15.8692
26 C1x C 9.8986 -14.6605
27 C5x C 10.6806 -13.5940
28 C8y C 27.5309 -13.0963
29 N1b N 28.8107 -15.1582
30 O5a O 27.6020 -17.2911
31 O5x O 10.2540 -12.2432
32 C8x C 28.8107 -13.7362
33 C8x C 27.5309 -11.6744
34 C1c C 30.0904 -15.8692
35 C8x C 30.0193 -13.0252
36 C8x C 28.7396 -10.9634
37 C5a C 31.2991 -15.1582
38 C8y C 30.0193 -11.6744
39 N1b N 32.5078 -15.8692
40 O5a O 31.2991 -13.7362
41 O1a O 31.1569 -10.9634
42 C1c C 33.6453 -15.1582
43 C5a C 34.8540 -15.7981
44 N1b N 36.0627 -15.0871
45 O5a O 34.8540 -17.2200
46 C1c C 37.2714 -15.7981
47 C5a C 38.4800 -15.0871
48 C1b C 37.2714 -17.2200
49 N1y N 39.7598 -15.7270
50 O5a O 38.4800 -13.6651
51 C1y C 41.1107 -15.7270
52 C1x C 39.3332 -17.0778
53 C1x C 41.5372 -17.0778
54 C5a C 42.3904 -15.0160
55 C1x C 40.3997 -17.8599
56 N1b N 43.6702 -15.7981
57 O5a O 42.3904 -13.5229
58 C1b C 19.2124 -13.8784
59 C8y C 20.4922 -13.2385
60 C8y C 20.9188 -11.9588
61 C8x C 21.6298 -14.0206
62 C8y C 22.2696 -11.9588
63 C8x C 20.2078 -10.7501
64 N4x N 22.7673 -13.2385
65 C8x C 22.9806 -10.6790
66 C8x C 20.9188 -9.5414
67 C8x C 22.2696 -9.5414
68 C1b C 15.5864 -17.4333
69 C8y C 16.7951 -18.1443
70 C8x C 16.7951 -19.4952
71 N5x N 18.0748 -19.9929
72 C8x C 18.9280 -18.9264
73 N4x N 18.2170 -17.7177
74 C1b C 22.7673 -17.2911
75 O1a O 23.9987 -18.0021
76 C1b C 30.1079 -17.2910
77 C1c C 31.3348 -17.9794
78 C1a C 32.5730 -17.2436
79 C1a C 31.3521 -19.4240
80 C1b C 33.6655 -13.7371
81 C1c C 34.8918 -13.0520
82 C1a C 36.1253 -13.7879
83 C1a C 34.9118 -11.6034
84 C1b C 44.9105 -15.1025
85 C1a C 46.1028 -15.8110
86 C1b C 38.4988 -17.9379
87 C1b C 38.4988 -19.3599
88 N1b N 37.2564 -20.0774
89 C2c C 36.0305 -19.3696
90 N1a N 34.8305 -20.0625
91 N2a N 36.0300 -17.9314
BOND 95
1 1 2 1
2 1 3 1
3 1 4 2
4 5 6 1
5 5 7 1
6 6 8 1
7 7 9 1
8 7 10 2
9 8 11 1
10 8 12 2
11 9 13 1
12 11 14 1
13 13 15 1
14 14 16 1
15 15 17 1
16 15 18 2
17 16 19 1
18 16 20 2
19 17 21 1
20 19 22 1
21 19 23 1
22 21 24 1
23 21 25 1
24 22 26 1
25 23 27 1
26 24 28 1
27 25 29 1
28 25 30 2
29 27 31 2
30 28 32 2
31 28 33 1
32 29 34 1
33 32 35 1
34 33 36 2
35 34 37 1
36 35 38 2
37 37 39 1
38 37 40 2
39 38 41 1
40 39 42 1
41 42 43 1
42 43 44 1
43 43 45 2
44 44 46 1
45 46 47 1
46 46 48 1
47 47 49 1
48 47 50 2
49 49 51 1
50 49 52 1
51 51 53 1
52 51 54 1
53 52 55 1
54 54 56 1
55 54 57 2
56 26 27 1
57 36 38 1
58 53 55 1
59 5 58 1
60 58 59 1
61 59 60 1
62 60 62 2
63 60 63 1
64 61 64 1
65 62 65 1
66 63 66 2
67 65 67 2
68 62 64 1
69 66 67 1
70 61 59 2
71 11 68 1
72 68 69 1
73 69 70 2
74 70 71 1
75 71 72 2
76 72 73 1
77 73 69 1
78 13 74 1
79 74 75 1
80 34 76 1
81 76 77 1
82 77 78 1
83 77 79 1
84 42 80 1
85 80 81 1
86 81 82 1
87 81 83 1
88 56 84 1
89 84 85 1
90 48 86 1
91 86 87 1
92 87 88 1
93 88 89 1
94 89 90 1
95 89 91 2
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