KEGG   DRUG: Epinephrine hydrochloride
Entry
D00996                      Drug                                   
Name
Epinephrine hydrochloride (JAN);
Adrenalin chloride (TN)
Formula
C9H13NO3. HCl
Exact mass
219.0662
Mol weight
219.6654
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
Metabolizing enzyme substrate
 DG01592  COMT substrate
 DG02917  MAO substrate
Remark
ATC code: A01AD01 B02BC09 C01CA24 R01AA14 R03AA01 S01EA01
Chemical structure group: DG00013
Product (DG00013): D00095<JP/US>
Product (mixture): D11290<US> D11569<US>
Efficacy
Vasoconstrictor, Adrenergic receptor agonist
Comment
Catecholamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Metabolism
Enzyme: COMT [HSA:1312], MAO [HSA:4128 4129]
Interaction
Structure map
map07214  beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AD Other agents for local oral treatment
     A01AD01 Epinephrine
      D00996  Epinephrine hydrochloride (JAN)
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BC Local hemostatics
     B02BC09 Epinephrine
      D00996  Epinephrine hydrochloride (JAN)
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA24 Epinephrine
      D00996  Epinephrine hydrochloride (JAN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA14 Epinephrine
      D00996  Epinephrine hydrochloride (JAN)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AA Alpha- and beta-adrenoreceptor agonists
     R03AA01 Epinephrine
      D00996  Epinephrine hydrochloride (JAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA01 Epinephrine
      D00996  Epinephrine hydrochloride (JAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Adrenaline (Epinephrine)
    D00996  Epinephrine hydrochloride (JAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00013  Epinephrine
     D00996  Epinephrine hydrochloride
  DG01456  Adrenergic receptor agonist
   DG00013  Epinephrine
    D00996  Epinephrine hydrochloride
  DG01951  Catecholamine adrenergic receptor agonist
   DG00013  Epinephrine
    D00996  Epinephrine hydrochloride
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00013  Epinephrine
    D00996  Epinephrine hydrochloride
  DG02917  MAO substrate
   DG00013  Epinephrine
    D00996  Epinephrine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00996  Epinephrine hydrochloride (JAN)
    ADRA2
     D00996  Epinephrine hydrochloride (JAN)
    ADRB
     D00996  Epinephrine hydrochloride (JAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00996
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00013  Epinephrine
  DG01456  Adrenergic receptor agonist
   DG00013  Epinephrine
  DG01951  Catecholamine adrenergic receptor agonist
   DG00013  Epinephrine
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00013  Epinephrine
  DG02917  MAO substrate
   DG00013  Epinephrine
Other DBs
CAS: 55-31-2
PubChem: 7848059
ChEBI: 6213
LigandBox: D00996
NIKKAJI: J231.250F
KCF data

ATOM        14
            1   X   Cl   16.4509  -13.8031
            2   C8y C    10.1428  -11.1333
            3   C8x C    10.1428  -12.5484
            4   C8x C     8.9257  -10.4344
            5   C1c C    11.3483  -10.4344
            6   C8x C     8.9257  -13.2589
            7   C8y C     7.7142  -11.1333
            8   C1b C    12.5596  -11.1275
            9   O1a O    11.3483   -9.0368
            10  C8y C     7.7142  -12.5484
            11  N1b N    13.7591  -10.4287
            12  O1a O     6.5030  -13.2356
            13  O1a O     6.5077  -10.4365
            14  C1a C    14.9684  -11.1206
BOND        13
            1     2   4 1
            2     2   5 1
            3     3   6 1
            4     4   7 2
            5     5   8 1
            6     5   9 1 #Up
            7     6  10 2
            8     8  11 1
            9    10  12 1
            10    7  10 1
            11    7  13 1
            12    2   3 2
            13   11  14 1

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (18)   
   KEGG ORTHOLOGY (9)   
   KEGG GENES (9)   
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