 | | DRUG: Neostigmine methylsulfate | |
| Entry |
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| Name |
Neostigmine methylsulfate (JP18/USP);
Bloxiverz (TN);
Prostigmin (TN) |
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| Product |
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| Generic |
NEOSTIGMINE (Dr.Reddy's Laboratories), NEOSTIGMINE (Medical Purchasing Solutions), NEOSTIGMINE METHYLSULFATE (Amneal Pharmaceuticals LLC), NEOSTIGMINE METHYLSULFATE (Amphastar Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (BE Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (Camber Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (Caplin Steriles Limited), NEOSTIGMINE METHYLSULFATE (Civica), NEOSTIGMINE METHYLSULFATE (Civica), NEOSTIGMINE METHYLSULFATE (Dr.Reddys Laboratories), NEOSTIGMINE METHYLSULFATE (Eugia US LLC), NEOSTIGMINE METHYLSULFATE (Gland Pharma Limited), NEOSTIGMINE METHYLSULFATE (HF Acquisition Co LLC), NEOSTIGMINE METHYLSULFATE (Henry Schein), NEOSTIGMINE METHYLSULFATE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (Hikma Pharmaceuticals USA), NEOSTIGMINE METHYLSULFATE (Hikma Pharmaceuticals USA), NEOSTIGMINE METHYLSULFATE (Hikma Pharmaceuticals USA), NEOSTIGMINE METHYLSULFATE (Hikma Pharmaceuticals USA), NEOSTIGMINE METHYLSULFATE (Indoco Remedies Limited), NEOSTIGMINE METHYLSULFATE (Medical Purchasing Solutions), NEOSTIGMINE METHYLSULFATE (Medical Purchasing Solutions), NEOSTIGMINE METHYLSULFATE (Medical Purchasing Solutions), NEOSTIGMINE METHYLSULFATE (Medical Purchasing Solutions), NEOSTIGMINE METHYLSULFATE (Meitheal Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (Nivagen Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (Par Pharmaceutical), NEOSTIGMINE METHYLSULFATE (Sagent Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (Somerset Therapeutics), NEOSTIGMINE METHYLSULFATE (Xellia Pharmaceuticals USA LLC), NEOSTIGMINE METHYLSULFATE (Xiromed LLC) |
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| Formula |
C12H19N2O2. CH3SO4
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| Exact mass |
334.1199
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| Mol weight |
334.3886
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG01719 Parasympathomimetic agent
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| Remark |
| Therapeutic category: | 1233 |
| Product (DG00987): | D00995<JP> D00998<JP/US> |
| Product (mixture): | D04114<JP> D09186<JP> |
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| Efficacy |
Parasympathomimetic, Acetylcholinesterase inhibitor |
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| Comment |
Physostigmine derivative
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| Target |
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| Pathway |
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| Interaction |
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| Structure map |
| map07220 | Cholinergic and anticholinergic drugs |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07A PARASYMPATHOMIMETICS
N07AA Anticholinesterases
N07AA01 Neostigmine
D00998 Neostigmine methylsulfate (JP18/USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EB Parasympathomimetics
S01EB06 Neostigmine
D00998 Neostigmine methylsulfate (JP18/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
12 Agents affecting peripheral nervous system
123 Autonomic nervous system agents
1233 Neostigmines
D00998 Neostigmine methylsulfate (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for ophthalmologic use
62 General eye drops
D00998 Neostigmine methylsulfate (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Third-class OTC drugs
Inorganic and organic chemicals
Neostigmine
D00998 Neostigmine methylsulfate (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG00987 Neostigmine
D00998 Neostigmine methylsulfate
DG01719 Parasympathomimetic agent
DG00987 Neostigmine
D00998 Neostigmine methylsulfate
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Carboxylic-ester hydrolases
ACHE
D00998 Neostigmine methylsulfate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00998 Neostigmine methylsulfate
D00998 Neostigmine methylsulfate injection
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG00987 Neostigmine
DG01719 Parasympathomimetic agent
DG00987 Neostigmine
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| Other DBs |
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| KCF data |
ATOM 22
1 C8y C 21.6932 -17.0217
2 C8x C 22.9128 -16.3157
3 C8x C 21.6932 -18.4279
4 O7a O 20.4737 -16.3214
5 C8y C 24.1207 -17.0217
6 C8x C 22.9128 -19.1281
7 C7a C 19.2600 -17.0274
8 C8x C 24.1207 -18.4221
9 N1d N 25.3402 -16.3157 #+
10 N1c N 18.0405 -16.3274
11 O6a O 19.2600 -18.4338
12 C1a C 26.7988 -15.3937
13 C1a C 24.6750 -15.2537
14 C1a C 26.1630 -17.5234
15 C1a C 16.8326 -17.0334
16 C1a C 18.0405 -14.9210
17 S4a S 32.7856 -17.4302
18 O2a O 31.4201 -17.4243
19 O1d O 32.7739 -18.7022
20 O1d O 32.7272 -15.8138
21 O1d O 34.1686 -17.4302 #-
22 C1a C 30.6791 -16.3389
BOND 21
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 3 6 2
6 4 7 1
7 5 8 2
8 5 9 1
9 7 10 1
10 7 11 2
11 9 12 1
12 9 13 1
13 9 14 1
14 10 15 1
15 10 16 1
16 6 8 1
17 17 18 1
18 17 19 2
19 17 20 2
20 17 21 1
21 18 22 1
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