| Entry |
|
|---|
| Name |
Ticlopidine hydrochloride (JP18/USP);
Ticlid (TN) |
|---|
| Formula |
C14H14ClNS. HCl
|
|---|
| Exact mass |
299.0302
|
|---|
| Mol weight |
300.2466
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
|
|---|
| Remark |
| Therapeutic category: | 3399 |
| Product (DG00156): | D01028<JP> |
|
|---|
| Efficacy |
Anticoagulant, Platelet aggregation inhibitor, Purinergic receptor P2Y12 antagonist |
|---|
| Disease |
Thrombotic thrombocytopenic purpura [DS: H00225] Aplastic anemia [DS: H01132] |
|---|
| Comment |
Thienopyridine derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
CYP inhibition: CYP2C19 [HSA: 1557], CYP1A2 [HSA: 1544], CYP2B6 [HSA: 1555], CYP2D6 [HSA: 1565]
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
B BLOOD AND BLOOD FORMING ORGANS
B01 ANTITHROMBOTIC AGENTS
B01A ANTITHROMBOTIC AGENTS
B01AC Platelet aggregation inhibitors excl. heparin
B01AC05 Ticlopidine
D01028 Ticlopidine hydrochloride (JP18/USP) <JP>
USP drug classification [BR:br08302]
Blood Products and Modifiers
Platelet Modifying Agents
Adenosine Diphosphate P2Y12 Inhibitors
Ticlopidine
D01028 Ticlopidine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
33 Blood and body fluid agents
339 Miscellaneous
3399 Others
D01028 Ticlopidine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
DG01808 Thienopyridine
DG00156 Ticlopidine
D01028 Ticlopidine hydrochloride
DG01809 P2Y12 receptor antagonist
DG01808 Thienopyridine
DG00156 Ticlopidine
D01028 Ticlopidine hydrochloride
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
DG00156 Ticlopidine
D01028 Ticlopidine hydrochloride
DG02892 CYP2B6 inhibitor
DG00156 Ticlopidine
D01028 Ticlopidine hydrochloride
DG01933 CYP2C19 inhibitor
DG00156 Ticlopidine
D01028 Ticlopidine hydrochloride
DG01645 CYP2D6 inhibitor
DG00156 Ticlopidine
D01028 Ticlopidine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Purine / pyrimidine
P2RY12
D01028 Ticlopidine hydrochloride (JP18/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01028 Ticlopidine hydrochloride
D01028 Ticlopidine hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01028
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
DG01808 Thienopyridine
DG00156 Ticlopidine
DG01809 P2Y12 receptor antagonist
DG01808 Thienopyridine
DG00156 Ticlopidine
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
DG00156 Ticlopidine
DG02892 CYP2B6 inhibitor
DG00156 Ticlopidine
DG01933 CYP2C19 inhibitor
DG00156 Ticlopidine
DG01645 CYP2D6 inhibitor
DG00156 Ticlopidine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 18
1 C8x C 10.2900 -8.6800
2 C8x C 10.2900 -10.0800
3 C8x C 11.5024 -10.7800
4 C8y C 12.7149 -10.0800
5 C8y C 12.7149 -8.6800
6 C8x C 11.5024 -7.9800
7 C1b C 13.9273 -10.7800
8 N1y N 15.1397 -10.0800
9 C1x C 15.1397 -8.6800
10 X Cl 13.9273 -7.9800
11 C1x C 16.3522 -10.7800
12 C8y C 17.5646 -10.0800
13 C8y C 17.5646 -8.6800
14 C1x C 16.3522 -7.9800
15 C8x C 18.8961 -10.5126
16 C8x C 19.7190 -9.3800
17 S2x S 18.8961 -8.2474
18 X Cl 22.1200 -9.4500
BOND 19
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 5 10 1
11 8 11 1
12 11 12 1
13 12 13 2
14 13 14 1
15 9 14 1
16 12 15 1
17 15 16 2
18 16 17 1
19 13 17 1
|
|---|
