| Entry |
|
|---|
| Name |
Spiperone (JAN/USAN);
Spiropitan (TN) |
|---|
| Formula |
C23H26FN3O2
|
|---|
| Exact mass |
395.2009
|
|---|
| Mol weight |
395.4698
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01940 Butyrophenone derivative
|
|---|
| Remark |
| Therapeutic category: | 1179 |
|
|---|
| Efficacy |
Antipsychotic, Dopamine D2 receptor antagonist |
|---|
| Comment |
Butyrophenone derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07031 | Antipsychotics - butyrophenones |
| map07213 | Dopamine receptor agonists/antagonists |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D01051 Spiperone (JAN/USAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
D01051 Spiperone
DG03200 Antipsychotic agent
DG01940 Butyrophenone derivative
D01051 Spiperone
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D01051 Spiperone (JAN/USAN) <JP>
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 29
1 N1y N 26.8289 -17.2797
2 N1x N 30.7754 -14.0613
3 C1x C 31.5060 -15.2542
4 N1y N 30.5878 -16.3243
5 C1z C 29.2967 -15.7828
6 C5x C 29.3413 -14.3917
7 C1x C 29.3410 -17.2043
8 C1x C 28.0502 -15.1344
9 C1x C 28.1362 -17.9562
10 C1x C 26.7826 -15.8742
11 C1b C 25.6795 -17.9800
12 C1b C 24.4742 -17.2770
13 C1b C 23.2763 -17.9743
14 C5a C 22.0770 -17.2652
15 O5a O 22.0581 -15.8696
16 C8y C 20.8608 -17.9699
17 C8x C 20.8640 -19.3738
18 C8x C 19.6478 -20.0787
19 C8y C 18.4295 -19.3777
20 C8x C 18.4272 -17.9721
21 C8x C 19.6434 -17.2674
22 X F 17.2132 -20.0824
23 C8y C 30.9070 -17.6744
24 C8x C 29.9061 -18.6173
25 C8x C 30.2294 -19.9858
26 C8x C 31.5762 -20.3901
27 C8x C 32.5771 -19.4472
28 C8x C 32.2538 -18.0787
29 O5x O 28.2672 -13.5087
BOND 32
1 7 9 1
2 8 10 1
3 9 1 1
4 10 1 1
5 2 3 1
6 3 4 1
7 4 5 1
8 5 6 1
9 6 2 1
10 5 7 1
11 5 8 1
12 14 16 1
13 11 12 1
14 12 13 1
15 13 14 1
16 14 15 2
17 16 17 1
18 17 18 2
19 18 19 1
20 19 20 2
21 20 21 1
22 21 16 2
23 19 22 1
24 11 1 1
25 4 23 1
26 23 24 2
27 24 25 1
28 25 26 2
29 26 27 1
30 27 28 2
31 23 28 1
32 6 29 2
|
|---|
