KEGG   DRUG: Penicillin G potassium
Entry
D01053                      Drug                                   
Name
Penicillin G potassium (USP);
Benzylpenicillin potassium (JP18);
Pfizerpen (TN)
Product
PENICILLIN G POTASSIUM (Baxter Healthcare Corporation)
  Generic
BUFFERED PENICILLIN G POTASSIUM (HF Acquisition Co LLC), PENICILLIN G POTASSIUM (Athenex Pharmaceutical Division), PENICILLIN G POTASSIUM (NorthStar Rx), PENICILLIN G POTASSIUM (Sandoz), PENICILLIN G POTASSIUM (WG Critical Care), PFIZERPEN (Roerig), PFIZERPEN (Roerig), PFIZERPEN (Roerig)
Formula
C16H17N2O4S. K
Exact mass
372.0546
Mol weight
372.4805
Structure
Simcomp
Class
Antibacterial
 DG01710  beta-Lactam antibiotic
  DG01713  Penicillin skeleton group
   DG01480  Penicillin
 DG01778  beta-Lactamase sensitive penicillin
Transporter substrate
 DG02860  SLC22A8 substrate
Remark
Therapeutic category: 6111
ATC code: J01CE01 S01AA14
Chemical structure group: DG00534
Product (DG00534): D01053<JP/US> D02157<JP/US> D05408<US>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
  Disease
Pneumonia due to Streptococcus pneumoniae [DS:H01321]
Endocarditis [DS:H00334]
Anthrax [DS:H00328]
Actinomycosis [DS:H01325]
Botulism [DS:H00339]
Gas gangrene [DS:H00336]
Tetanus [DS:H00337]
Diphtheria [DS:H00343]
Listeria infections [DS:H00332]
Pasteurella infections [DS:H00306]
Haverhill fever [DS:H01314]
Rat bite fever [DS:H01314]
Gonococcal infections [DS:H00315]
Syphilis [DS:H00354]
Meningococcal meningitis [DS:H00314]
Target
penicillin binding protein
  Pathway
ko00550  Peptidoglycan biosynthesis
Metabolism
Transporter: SLC22A8 [HSA:9376]
Interaction
Structure map
map07011  Penicillins
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01C BETA-LACTAM ANTIBACTERIALS, PENICILLINS
    J01CE Beta-lactamase sensitive penicillins
     J01CE01 Benzylpenicillin
      D01053  Penicillin G potassium (USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA14 Benzylpenicillin
      D01053  Penicillin G potassium (USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Beta-lactam, Penicillins
   Penicillin G
    D01053  Penicillin G potassium (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   611  Acting mainly on gram-positive bacteria
    6111  Penicillins
     D01053  Penicillin G potassium (USP); Benzylpenicillin potassium (JP18)
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01713  Penicillin skeleton group
    DG01480  Penicillin
     DG00534  Benzylpenicillin
      D01053  Penicillin G potassium
  DG01778  beta-Lactamase sensitive penicillin
   DG00534  Benzylpenicillin
    D01053  Penicillin G potassium
 Transporter substrate
  DG02860  SLC22A8 substrate
   D01053  Penicillin G potassium
Drug classes [BR:br08332]
 Antibacterial
  DG01480  Penicillin
   D01053  Penicillin G potassium
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   beta-Lactamase sensitive penicillin
    D01053  Penicillin G potassium (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01053  Benzylpenicillin potassium
  D01053  Benzylpenicillin potassium for injection
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D01053
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01713  Penicillin skeleton group
    DG01480  Penicillin
     DG00534  Benzylpenicillin
  DG01778  beta-Lactamase sensitive penicillin
   DG00534  Benzylpenicillin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   beta-Lactamase sensitive penicillin
    DG00534  Benzylpenicillin
Other DBs
CAS: 113-98-4
PubChem: 7848116
ChEBI: 7963
LigandBox: D01053
NIKKAJI: J9.869H
KCF data

ATOM        24
            1   C1y C    28.4000  -14.5226
            2   C5x C    28.4000  -15.9274
            3   N1y N    29.8049  -15.9274
            4   C1y C    29.8049  -14.5226
            5   C1y C    31.1394  -16.3488
            6   C1z C    31.9822  -15.2249
            7   S2x S    31.1394  -14.1010
            8   C1a C    32.9657  -16.2083
            9   C1a C    32.9657  -14.2415
            10  C6a C    31.6311  -17.6833
            11  O6a O    33.0358  -17.6833 #-
            12  O6a O    30.7881  -18.8071
            13  N1b N    27.2059  -13.8201
            14  C5a C    26.0118  -14.5226
            15  O5x O    27.2059  -16.6297
            16  O5a O    26.0118  -15.9274
            17  C1b C    24.7923  -13.8250
            18  C8y C    23.5999  -14.5203
            19  C8x C    22.3863  -13.8196
            20  C8x C    21.1728  -14.5203
            21  C8x C    21.1728  -15.9215
            22  C8x C    22.3863  -16.6221
            23  C8x C    23.5999  -15.9215
            24  Z   K    34.5100  -17.7100 #+
BOND        25
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     1   4 1
            5     3   5 1
            6     5   6 1
            7     6   7 1
            8     4   7 1
            9     6   8 1
            10    6   9 1
            11    5  10 1 #Down
            12   10  11 1
            13   10  12 2
            14    1  13 1 #Up
            15   13  14 1
            16    2  15 2
            17   14  16 2
            18   14  17 1
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   18  23 1

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