| Entry |
|
|---|
| Name |
Cilazapril (USAN);
Cilazapril hydrate (JP18);
Inhibace (TN) |
|---|
| Formula |
C22H31N3O5. H2O
|
|---|
| Exact mass |
435.2369
|
|---|
| Mol weight |
435.5139
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antihypertensive, Angiotensin-converting enzyme inhibitor |
|---|
| Comment |
Active form of prodrug: Cilazaprilat [CPD: C17309]
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07217 | Renin-angiotensin system inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
C09A ACE INHIBITORS, PLAIN
C09AA ACE inhibitors, plain
C09AA08 Cilazapril
D01069 Cilazapril (USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG00340 Cilazapril
D01069 Cilazapril
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
DG00340 Cilazapril
D01069 Cilazapril
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Peptidyl-dipeptidases
ACE (CD143)
D01069 Cilazapril (USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01069 Cilazapril hydrate
D01069 Cilazapril tablets
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG00340 Cilazapril
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
DG00340 Cilazapril
Prodrugs [br08324.html]
DG00340
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 31
1 C1x C 19.1800 -19.8800
2 N1y N 18.3400 -18.7600
3 N1y N 18.6900 -17.4300
4 C5x C 19.9500 -16.8700
5 C1x C 20.5800 -19.8800
6 C1y C 21.2100 -17.5000
7 C1x C 21.4900 -18.8300
8 C1y C 17.6400 -16.4500
9 C1x C 16.3100 -16.8700
10 C1x C 15.9600 -18.2000
11 C1x C 17.0100 -19.1800
12 C6a C 17.9490 -15.0845
13 O6a O 19.2686 -14.6742
14 O6a O 16.8878 -14.1042
15 O5x O 19.9818 -15.4704
16 C7a C 23.9149 -18.8300
17 C1c C 23.9149 -17.4300
18 N1b N 22.7024 -16.7300
19 C1b C 25.1460 -16.7190
20 C1b C 26.3512 -17.4147
21 C8y C 27.5335 -16.7319
22 O7a O 25.1460 -19.5410
23 O6a O 22.7214 -19.5192
24 C1b C 26.3512 -18.8453
25 C1a C 27.5335 -19.5281
26 C8x C 28.7275 -17.4212
27 C8x C 29.9399 -16.7212
28 C8x C 29.9399 -15.3212
29 C8x C 28.7460 -14.6319
30 C8x C 27.5335 -15.3319
31 O0 O 32.2000 -18.4800
BOND 32
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 2 11 1
13 8 12 1 #Up
14 12 13 2
15 12 14 1
16 4 15 2
17 17 16 1 #Up
18 17 18 1
19 6 18 1 #Up
20 17 19 1
21 19 20 1
22 20 21 1
23 16 22 1
24 16 23 2
25 22 24 1
26 24 25 1
27 21 26 2
28 26 27 1
29 27 28 2
30 28 29 1
31 29 30 2
32 21 30 1
|
|---|
