KEGG   DRUG: Clindamycin phosphate
Entry
D01073                      Drug                                   
Name
Clindamycin phosphate (JP18/USP);
Cleocin (TN);
Dalacin-S (TN);
Evoclin (TN)
Product
CLEOCIN (Pharmacia & Upjohn Company LLC), CLEOCIN (Pharmacia & Upjohn Company LLC), CLEOCIN PHOSPHATE (Henry Schein), CLEOCIN PHOSPHATE (Medical Purchasing Solutions), CLEOCIN PHOSPHATE (Medical Purchasing Solutions), CLEOCIN PHOSPHATE (Medical Purchasing Solutions), CLEOCIN PHOSPHATE (Medical Purchasing Solutions), CLEOCIN PHOSPHATE (Pharmacia & Upjohn Company LLC), CLEOCIN PHOSPHATE (Pharmacia & Upjohn Company LLC), CLEOCIN T (Pharmacia & Upjohn Company LLC), CLINDAGEL (Bausch Health US), CLINDAMYCIN PHOSPHATE (ALMAJECT), CLINDAMYCIN PHOSPHATE (Baxter Healthcare Corporation), CLINDAMYCIN PHOSPHATE (Medical Purchasing Solutions), CLINDAMYCIN PHOSPHATE (Medical Purchasing Solutions), CLINDAMYCIN PHOSPHATE (Medical Purchasing Solutions), CLINDAMYCIN PHOSPHATE (Medical Purchasing Solutions), CLINDESSE (Padagis Israel Pharmaceuticals), XACIATO (Organon LLC)
  Generic
CLINDACIN (Medimetriks Pharmaceuticals), CLINDACIN ETZ (Medimetriks Pharmaceuticals), CLINDACIN P (Medimetriks Pharmaceuticals), CLINDAMYCIN (Henry Schein), CLINDAMYCIN (Medical Purchasing Solutions), CLINDAMYCIN (Medical Purchasing Solutions), CLINDAMYCIN (Medical Purchasing Solutions), CLINDAMYCIN (Medical Purchasing Solutions), CLINDAMYCIN (Medical Purchasing Solutions), CLINDAMYCIN (Medical Purchasing Solutions), CLINDAMYCIN (Sagent Pharmaceuticals), CLINDAMYCIN (Sagent Pharmaceuticals), CLINDAMYCIN IN 5 PERCENT DEXTROSE (Civica), CLINDAMYCIN IN 5 PERCENT DEXTROSE (Sandoz), CLINDAMYCIN PHOAPHATE TOPICAL SOLUTION USP, 1% (Encube Ethicals Private Limited), CLINDAMYCIN PHOAPHATE TOPICAL SOLUTION, 1% (Preferred Pharmaceuticals), CLINDAMYCIN PHOAPHATE TOPICAL USP, 1% (A-S Medication Solutions), CLINDAMYCIN PHOSPHATE (A-S Medication Solutions), CLINDAMYCIN PHOSPHATE (A-S Medication Solutions), CLINDAMYCIN PHOSPHATE (A-S Medication Solutions), CLINDAMYCIN PHOSPHATE (A-S Medication Solutions), CLINDAMYCIN PHOSPHATE (A-S Medication Solutions), CLINDAMYCIN PHOSPHATE (A-S Medication Solutions), CLINDAMYCIN PHOSPHATE (Alembic Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Amneal Pharmaceuticals NY LLC), CLINDAMYCIN PHOSPHATE (Amneal Pharmaceuticals NY LLC), CLINDAMYCIN PHOSPHATE (Baxter Healthcare Corporation), CLINDAMYCIN PHOSPHATE (Baxter Healthcare Corporation), CLINDAMYCIN PHOSPHATE (Baxter Healthcare Corporation), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), CLINDAMYCIN PHOSPHATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Encube Ethicals Private Limited), CLINDAMYCIN PHOSPHATE (Encube Ethicals Private Limited), CLINDAMYCIN PHOSPHATE (GLENMARK PHARMACEUTICALS), CLINDAMYCIN PHOSPHATE (GLENMARK PHARMACEUTICALS), CLINDAMYCIN PHOSPHATE (Glasshouse Pharmaceuticals Limited Canada), CLINDAMYCIN PHOSPHATE (Greenstone LLC), CLINDAMYCIN PHOSPHATE (Greenstone LLC), CLINDAMYCIN PHOSPHATE (NORTHSTAR RX LLC), CLINDAMYCIN PHOSPHATE (NORTHSTAR RX LLC), CLINDAMYCIN PHOSPHATE (Oceanside Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Padagis Israel Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Padagis Israel Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Padagis Israel Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Padagis Israel Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Padagis Israel Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Preferred Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Preferred Pharmaceuticals), CLINDAMYCIN PHOSPHATE (RPK Pharmaceuticals), CLINDAMYCIN PHOSPHATE (RPK Pharmaceuticals), CLINDAMYCIN PHOSPHATE (RPK Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Solaris Pharma Corporation), CLINDAMYCIN PHOSPHATE (Solaris Pharma Corporation), CLINDAMYCIN PHOSPHATE (Taro Pharmaceuticals U.S.A.), CLINDAMYCIN PHOSPHATE (Taro Pharmaceuticals U.S.A.), CLINDAMYCIN PHOSPHATE (Taro Pharmaceuticals U.S.A.), CLINDAMYCIN PHOSPHATE (Taro Pharmaceuticals U.S.A.), CLINDAMYCIN PHOSPHATE (Viona Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Viona Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Zydus Lifesciences Limited), CLINDAMYCIN PHOSPHATE (Zydus Lifesciences Limited)
Formula
C18H34ClN2O8PS
Exact mass
504.1462
Mol weight
504.9629
Structure
Simcomp
Class
Antibacterial
 DG01578  Lincosamide antibiotic
Remark
Same as: C11728
Therapeutic category: 2634 6112
ATC code: D10AF01 G01AA10 J01FF01
Chemical structure group: DG00435
Product (DG00435): D00277<US> D01073<JP/US> D01990<US> D02132<JP/US>
Product (mixture): D10602<JP/US> D11084<US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Infections due to susceptible strains of Streptococci [DS:H00333]
Acne vulgaris [DS:H01445]
Comment
Semisynthetic lincosamide
Active form of prodrug: Clindamycin [DR:D00277]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF01 Clindamycin
      D01073  Clindamycin phosphate (JP18/USP) <JP/US>
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA10 Clindamycin
      D01073  Clindamycin phosphate (JP18/USP) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FF Lincosamides
     J01FF01 Clindamycin
      D01073  Clindamycin phosphate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Clindamycin
    D01073  Clindamycin phosphate (JP18/USP)
 Dermatological Agents
  Topical Anti-infectives
   Antibacterials, dermatological
    Clindamycin
     D01073  Clindamycin phosphate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   263  Suppurative dermatosis agents
    2634  Antibiotics for external use
     D01073  Clindamycin phosphate (JP18/USP)
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   611  Acting mainly on gram-positive bacteria
    6112  Lincomycins
     D01073  Clindamycin phosphate (JP18/USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01578  Lincosamide antibiotic
   DG00435  Clindamycin
    D01073  Clindamycin phosphate
Drug classes [BR:br08332]
 Antibacterial
  DG01578  Lincosamide antibiotic
   D01073  Clindamycin phosphate
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Lincosamide
    D01073  Clindamycin phosphate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01073  Clindamycin phosphate
  D01073  Clindamycin phosphate injection
Prodrugs [br08324.html]
 D01073
Drug groups [BR:br08330]
 Antibacterial
  DG01578  Lincosamide antibiotic
   DG00435  Clindamycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Lincosamide
    DG00435  Clindamycin
Prodrugs [br08324.html]
 DG00435
Other DBs
CAS: 24729-96-2
PubChem: 7848136
ChEBI: 201756 3746
LigandBox: D01073
NIKKAJI: J286.383I
KCF data

ATOM        31
            1   C1y C    20.3420  -15.6751
            2   C1y C    20.3420  -17.0766
            3   C1y C    21.5567  -17.7773
            4   C1y C    22.7713  -17.0766
            5   C1y C    22.7713  -15.6751
            6   O2x O    21.5567  -14.9744
            7   S2a S    23.9859  -14.9744
            8   C1a C    23.9859  -13.5730
            9   O2b O    23.9859  -17.7773
            10  O1a O    21.5567  -19.1789
            11  O1a O    19.1275  -17.7773
            12  C1c C    19.1275  -14.9744
            13  N1b N    17.9129  -15.6751
            14  C1c C    19.1275  -13.5730
            15  X   Cl   17.9129  -12.8722
            16  C1a C    20.3420  -12.8722
            17  C5a C    16.6983  -14.9744
            18  C1y C    15.4837  -15.6751
            19  O5a O    16.6983  -13.5730
            20  N1y N    14.3578  -14.8803
            21  C1x C    13.2387  -15.7030
            22  C1y C    13.6855  -17.0322
            23  C1x C    15.0690  -17.0253
            24  C1a C    14.3578  -13.4808
            25  C1b C    12.9918  -18.2479
            26  C1b C    11.6141  -18.2550
            27  C1a C    10.9162  -19.4785
            28  P1b P    25.2093  -17.0704
            29  O1c O    26.4215  -16.3706
            30  O1c O    24.5068  -15.8540
            31  O1c O    25.9066  -18.2777
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     5   7 1 #Down
            8     7   8 1
            9     4   9 1 #Down
            10    3  10 1 #Up
            11    2  11 1 #Up
            12    1  12 1
            13   12  13 1
            14   12  14 1
            15   14  15 1 #Up
            16   14  16 1
            17   13  17 1
            18   18  17 1 #Down
            19   17  19 2
            20   18  20 1
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24   18  23 1
            25   20  24 1
            26   22  25 1 #Up
            27   25  26 1
            28   26  27 1
            29    9  28 1
            30   28  29 1
            31   28  30 2
            32   28  31 1

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   SIDER (1)   
Chemical substance (5)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (2)   
   NIKKAJI (1)   
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