 | | DRUG: Hydroxyzine pamoate | |
| Entry |
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| Name |
Hydroxyzine pamoate (JP18/USP);
Atarax-P (TN);
Vistaril pamoate (TN) |
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| Product |
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| Generic |
HYDROXYZINE PAMOATE (A-S Medication Solutions), HYDROXYZINE PAMOATE (A-S Medication Solutions), HYDROXYZINE PAMOATE (A-S Medication Solutions), HYDROXYZINE PAMOATE (A-S Medication Solutions), HYDROXYZINE PAMOATE (A-S Medication Solutions), HYDROXYZINE PAMOATE (A-S Medication Solutions), HYDROXYZINE PAMOATE (American Health Packaging), HYDROXYZINE PAMOATE (American Health Packaging), HYDROXYZINE PAMOATE (Amneal Pharmaceuticals of New York LLC), HYDROXYZINE PAMOATE (Aphena Pharma Solutions - Tennessee), HYDROXYZINE PAMOATE (Aphena Pharma Solutions - Tennessee), HYDROXYZINE PAMOATE (Aphena Pharma Solutions - Tennessee), HYDROXYZINE PAMOATE (Aphena Pharma Solutions - Tennessee), HYDROXYZINE PAMOATE (Aphena Pharma Solutions - Tennessee), HYDROXYZINE PAMOATE (Aphena Pharma Solutions - Tennessee), HYDROXYZINE PAMOATE (Aphena Pharma Solutions - Tennessee), HYDROXYZINE PAMOATE (AvPAK), HYDROXYZINE PAMOATE (Bryant Ranch Prepack), HYDROXYZINE PAMOATE (Bryant Ranch Prepack), HYDROXYZINE PAMOATE (Bryant Ranch Prepack), HYDROXYZINE PAMOATE (Bryant Ranch Prepack), HYDROXYZINE PAMOATE (Bryant Ranch Prepack), HYDROXYZINE PAMOATE (Bryant Ranch Prepack), HYDROXYZINE PAMOATE (Bryant Ranch Prepack), HYDROXYZINE PAMOATE (Bryant Ranch Prepack), HYDROXYZINE PAMOATE (Bryant Ranch Prepack), HYDROXYZINE PAMOATE (Cardinal Health 107), HYDROXYZINE PAMOATE (Cardinal Health 107), HYDROXYZINE PAMOATE (Chartwell RX), HYDROXYZINE PAMOATE (Denton Pharma), HYDROXYZINE PAMOATE (DirectRx), HYDROXYZINE PAMOATE (Direct_Rx), HYDROXYZINE PAMOATE (Direct_Rx), HYDROXYZINE PAMOATE (Direct_Rx), HYDROXYZINE PAMOATE (Greenstone LLC), HYDROXYZINE PAMOATE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), HYDROXYZINE PAMOATE (Major Pharmaceuticals), HYDROXYZINE PAMOATE (NCS HealthCare of KY), HYDROXYZINE PAMOATE (Northwind Pharmaceuticals), HYDROXYZINE PAMOATE (Northwind Pharmaceuticals), HYDROXYZINE PAMOATE (Northwind Pharmaceuticals), HYDROXYZINE PAMOATE (Northwind Pharmaceuticals), HYDROXYZINE PAMOATE (NuCare Pharmaceuticals), HYDROXYZINE PAMOATE (NuCare Pharmaceuticals), HYDROXYZINE PAMOATE (NuCare Pharmaceuticals), HYDROXYZINE PAMOATE (NuCare Pharmaceuticals), HYDROXYZINE PAMOATE (NuCare Pharmaceuticals), HYDROXYZINE PAMOATE (NuCare Pharmaceuticals), HYDROXYZINE PAMOATE (PD-Rx Pharmaceuticals), HYDROXYZINE PAMOATE (PD-Rx Pharmaceuticals), HYDROXYZINE PAMOATE (Pharmasource Meds), HYDROXYZINE PAMOATE (Preferred Pharmaceuticals), HYDROXYZINE PAMOATE (Preferred Pharmaceuticals), HYDROXYZINE PAMOATE (Preferred Pharmaceuticals), HYDROXYZINE PAMOATE (Proficient Rx LP), HYDROXYZINE PAMOATE (Proficient Rx LP), HYDROXYZINE PAMOATE (Proficient Rx LP), HYDROXYZINE PAMOATE (Proficient Rx LP), HYDROXYZINE PAMOATE (Proficient Rx LP), HYDROXYZINE PAMOATE (Proficient Rx LP), HYDROXYZINE PAMOATE (Quality Care Products), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (RedPharm Drug), HYDROXYZINE PAMOATE (Sandoz), HYDROXYZINE PAMOATE (Teva Pharmaceuticals USA) |
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| Formula |
C23H16O6. C21H27ClN2O2
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| Exact mass |
762.2708
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| Mol weight |
763.2738
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| Structure |
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Dermatological agent
DG03243 Atopic dermatitis agent
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| Remark |
| Therapeutic category: | 1179 |
| Product (DG00912): | D00672<JP/US> D01096<JP/US> |
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| Efficacy |
Antianxiety, Minor tranquilizer, H1 receptor antagonist |
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| Disease |
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| Comment |
In vitro studies suggested a role for CYP3A4 and CYP3A5 in the metabolism of Hydroxyzine.
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Interaction |
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| Structure map |
| map07212 | Histamine H1 receptor antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05B ANXIOLYTICS
N05BB Diphenylmethane derivatives
N05BB01 Hydroxyzine
D01096 Hydroxyzine pamoate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Anxiolytics
Anxiolytics, Other
Hydroxyzine
D01096 Hydroxyzine pamoate (JP18/USP)
Respiratory Tract/Pulmonary Agents
Antihistamines
Histamine (H1) Receptor Antagonists, Sedating
Hydroxyzine
D01096 Hydroxyzine pamoate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D01096 Hydroxyzine pamoate (JP18/USP)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00912 Hydroxyzine
D01096 Hydroxyzine pamoate
Dermatological agent
DG03243 Atopic dermatitis agent
D01096 Hydroxyzine pamoate
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D01096 Hydroxyzine pamoate
Dermatological agent
DG03243 Atopic dermatitis agent
D01096 Hydroxyzine pamoate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D01096 Hydroxyzine pamoate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01096 Hydroxyzine pamoate
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00912 Hydroxyzine
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| Other DBs |
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| KCF data |
ATOM 55
1 C8x C 33.9216 -16.0049
2 C8x C 33.9216 -17.3788
3 C8x C 35.1113 -18.0656
4 C8x C 36.3012 -17.3788
5 C8y C 36.3012 -16.0049
6 C8y C 35.1113 -15.3180
7 C8y C 37.4909 -15.3180
8 C8y C 37.4909 -13.9441
9 C8y C 36.3012 -13.2573
10 C8x C 35.1113 -13.9441
11 C1b C 39.3696 -16.1435
12 C8y C 40.9559 -15.3280
13 C8y C 42.1205 -16.0004
14 C8y C 43.3103 -15.3134
15 C8x C 43.3103 -13.9396
16 C8y C 42.1456 -13.2672
17 C8y C 40.9558 -13.9542
18 C8x C 42.1205 -17.3742
19 C8x C 43.3103 -18.0610
20 C8x C 44.5000 -17.3741
21 C8x C 44.5000 -16.0003
22 C6a C 36.3012 -11.8836
23 O6a O 37.5094 -11.1859
24 O6a O 35.1299 -11.2073
25 C6a C 42.1454 -11.8835
26 O6a O 40.9699 -11.2050
27 O6a O 43.3494 -11.1881
28 O1a O 38.6826 -13.2561
29 O1a O 39.7409 -13.2527
30 C8x C 22.7711 -15.9341
31 C8y C 22.7711 -17.3375
32 C8x C 23.9865 -18.0392
33 C8x C 25.2019 -17.3375
34 C8y C 25.2019 -15.9341
35 C8x C 23.9865 -15.2324
36 C8x C 27.6326 -17.3375
37 C8y C 27.6326 -15.9341
38 C1c C 26.4173 -15.2324
39 N1y N 26.4173 -13.8290
40 C1x C 27.6347 -13.1261
41 C1x C 27.6347 -11.7227
42 N1y N 26.4193 -11.0210
43 C1x C 25.2019 -11.7239
44 C1x C 25.2019 -13.1273
45 C8x C 28.8481 -18.0392
46 C8x C 30.0634 -17.3375
47 C8x C 30.0634 -15.9341
48 C8x C 28.8481 -15.2324
49 X Cl 21.5558 -18.0392
50 C1b C 26.4193 -9.6188
51 C1b C 27.6352 -8.9168
52 O2a O 28.8338 -9.6089
53 C1b C 30.0239 -8.9220
54 C1b C 31.2181 -9.6117
55 O1a O 32.4105 -8.9233
BOND 60
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 6 10 1
12 7 11 1
13 11 12 1
14 12 13 1
15 13 14 2
16 14 15 1
17 15 16 2
18 16 17 1
19 12 17 2
20 13 18 1
21 18 19 2
22 19 20 1
23 20 21 2
24 14 21 1
25 9 22 1
26 22 23 2
27 22 24 1
28 16 25 1
29 25 26 2
30 25 27 1
31 8 28 1
32 17 29 1
33 30 31 2
34 31 32 1
35 32 33 2
36 33 34 1
37 34 35 2
38 30 35 1
39 36 37 1
40 37 38 1
41 34 38 1
42 38 39 1
43 39 40 1
44 40 41 1
45 41 42 1
46 42 43 1
47 43 44 1
48 39 44 1
49 36 45 2
50 45 46 1
51 46 47 2
52 47 48 1
53 37 48 2
54 31 49 1
55 42 50 1
56 50 51 1
57 51 52 1
58 52 53 1
59 53 54 1
60 54 55 1
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