KEGG DRUG: Adapalene

DRUG: Adapalene

Entry

D01112                      Drug

Name

Adapalene (JAN/USP/INN);
Differin (TN)

Product

DIFFERIN (GALDERMA LABORATORIES), DIFFERIN (Galderma Laboratories), DIFFERIN (Galderma Laboratories)

Generic

ADAPALENE (Actavis Pharma), ADAPALENE (Alembic Pharmaceuticals), ADAPALENE (Bryant Ranch Prepack), ADAPALENE (Bryant Ranch Prepack), ADAPALENE (CALL INC. (dba Rochester Pharmaceuticals)), ADAPALENE (E. Fougera & Co. a division of Fougera Pharmaceuticals), ADAPALENE (Mayne Pharma Commercial LLC.), ADAPALENE (Padagis Israel Pharmaceuticals), ADAPALENE (Taro Pharmaceuticals U.S.A.), ADAPALENE GEL USP, 0.3% (Encube Ethicals Private Limited), ADAPALENE TOPICAL SOLUTION (Allegis Holdings LLC), ADAPALENE TOPICAL SOLUTION (CALL INC (d.b.a Rochester Pharmaceuticals))

Formula

C28H28O3

Exact mass

412.2038

Mol weight

412.5201

Structure

Class

Vitamin and mineral
DG01604 Retinol derivative

Remark

Therapeutic category:

2699

ATC code:

D10AD03

Product:

D01112<JP/US>

Product (mixture):

D10792<JP/US>

Efficacy

Anti-acne, Retinoic acid receptor (RAR) agonist

Disease

Acne vulgaris [DS:H01445]

Target

NR1B3 (RARG) [HSA:5916] [KO:K08529]
NR1B2 (RARB) [HSA:5915] [KO:K08528]
NR2B3 (RXRG) [HSA:6258] [KO:K08526]
NR2B2 (RXRB) [HSA:6257] [KO:K08525]

Pathway

hsa04659

Th17 cell differentiation

Structure map

map07223

Retinoic acid receptor (RAR) and retinoid X receptor (RXR) agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AD Retinoids for topical use in acne
     D10AD03 Adapalene
      D01112  Adapalene (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
  Acne and Rosacea Agents
   Retinoids
    Adapalene
     D01112  Adapalene (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  26  Epidermides
   269  Miscellaneous
    2699  Others
     D01112  Adapalene (JAN/USP/INN)
Drug groups [BR:br08330]
Vitamin and mineral
  DG01604  Retinol derivative
   D01112  Adapalene
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Thyroid hormone like receptors
   Retinoic acid receptor (RAR)
    NR1B2 (RARB)
     D01112  Adapalene (JAN/USP/INN) <JP/US>
    NR1B3 (RARG)
     D01112  Adapalene (JAN/USP/INN) <JP/US>
  Hepatocyte nuclear factor 4 like receptors
   Retinoid X receptor (RXR)
    NR2B2 (RXRB)
     D01112  Adapalene (JAN/USP/INN) <JP/US>
    NR2B3 (RXRG)
     D01112  Adapalene (JAN/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D01112  Ibuprofen piconol
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D01112
Rx-to-OTC switch list in the USA [br08315.html]
D01112

Other DBs

CAS:	106685-40-9

PubChem:

ChEBI:

LigandBox:

NIKKAJI:

KCF data

ATOM        31
            1   C1z C    17.7219  -19.1703
            2   C1x C    16.9759  -20.6495
            3   C1y C    16.9759  -21.9529
            4   C1y C    16.5531  -21.1864
            5   C1y C    18.8839  -21.1864
            6   C1x C    15.2964  -22.4094
            7   C1x C    18.1087  -23.0011
            8   C1x C    16.5531  -19.8380
            9   C1x C    17.7237  -21.8606
            10  C1x C    18.8874  -19.8380
            11  C8x C    20.0526  -13.7790
            12  C8y C    20.0526  -15.1274
            13  C8x C    21.2231  -15.8016
            14  C8x C    21.2231  -13.1048
            15  C8y C    22.3869  -13.7790
            16  C8y C    22.3811  -15.1274
            17  C8x C    23.5460  -15.8065
            18  C8x C    24.7166  -15.1374
            19  C8y C    24.7223  -13.7890
            20  C8x C    23.5574  -13.1099
            21  C8y C    18.8851  -15.8022
            22  C8x C    17.7197  -15.1251
            23  C8x C    16.5524  -15.8000
            24  C8y C    16.5531  -17.1484
            25  C8y C    17.7212  -17.8219
            26  C8x C    18.8885  -17.1472
            27  C6a C    25.8929  -13.1198
            28  O6a O    27.0577  -13.7989
            29  O6a O    25.8988  -11.7714
            30  O2a O    15.3856  -17.8232
            31  C1a C    15.3864  -19.1716
BOND        36
            1    14  11 1
            2     1   2 1
            3     2   3 1
            4     8   4 1
            5     4   9 1
            6     9   5 1
            7    15  16 1
            8    16  17 1
            9    17  18 2
            10   18  19 1
            11   19  20 2
            12   20  15 1
            13    5  10 1
            14   12  21 1
            15   10   1 1
            16    1   8 1
            17    3   6 1
            18    3   7 1
            19    4   6 1
            20   21  22 2
            21   22  23 1
            22   23  24 2
            23   24  25 1
            24   25  26 2
            25   26  21 1
            26    5   7 1
            27   19  27 1
            28   11  12 2
            29   27  28 2
            30   12  13 1
            31   27  29 1
            32   13  16 2
            33   24  30 1
            34   15  14 2
            35   30  31 1
            36   25   1 1

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