KEGG DRUG: Eplerenone

DRUG: Eplerenone

Entry

D01115                      Drug

Name

Eplerenone (JP18/USAN/INN);
Inspra (TN)

Product

INSPRA (Pfizer Laboratories Div Pfizer)

Generic

EPLERENONE (Accord Healthcare), EPLERENONE (American Health Packaging), EPLERENONE (AvKARE), EPLERENONE (Breckenridge Pharmaceutical), EPLERENONE (Camber Pharmaceuticals), EPLERENONE (Eon Labs), EPLERENONE (Greenstone LLC), EPLERENONE (Prasco Laboratories), EPLERENONE (Proficient Rx LP), EPLERENONE (Slate Run Pharmaceuticals), EPLERENONE (Westminster Pharmaceuticals)

Formula

C24H30O6

Exact mass

414.2042

Mol weight

414.4914

Structure

Simcomp

Class

Cardiovascular agent
DG03231  Antihypertensive
  DG01676  Aldosterone antagonist
DG01885  Potassium-sparing diuretic
Metabolizing enzyme substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Same as:

C12512

Therapeutic category:

2149

ATC code:

C03DA04

Product:

D01115<JP/US>

Efficacy

Antihypertensive, Aldosterone antagonist

Disease

Hypertension [DS:H01633]

Comment

Spironolactone derivative

Target

NR3C2 (MR) [HSA:4306] [KO:K08555]

Pathway

hsa04960

Aldosterone-regulated sodium reabsorption

Metabolism

Enzyme: CYP3A4 [HSA:1576]

Interaction

Structure map

map07225

Glucocorticoid and mineralocorticoid receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03D ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
    C03DA Aldosterone antagonists
     C03DA04 Eplerenone
      D01115  Eplerenone (JP18/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
  Mineralocorticoid Receptor Antagonist
   Eplerenone
    D01115  Eplerenone (JP18/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01115  Eplerenone (JP18/USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG03231  Antihypertensive
   DG01676  Aldosterone antagonist
    D01115  Eplerenone
  DG01885  Potassium-sparing diuretic
   D01115  Eplerenone
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D01115  Eplerenone
Drug classes [BR:br08332]
Cardiovascular agent
  DG01676  Aldosterone antagonist
   D01115  Eplerenone
  DG03231  Antihypertensive
   D01115  Eplerenone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C2 (MR)
     D01115  Eplerenone (JP18/USAN/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D01115  Eplerenone
  D01115  Eplerenone tablets
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D01115
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D01115
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D01115
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D01115

Other DBs

CAS:	107724-20-9

PubChem:

7848178

ChEBI:

31547

PDB-CCD:

YNU[PDBj]

LigandBox:

D01115

NIKKAJI:

J835.298D

KCF data

ATOM        30
            1   C1z C    25.7600  -21.4200
            2   C1z C    24.5000  -22.1200
            3   C1x C    26.8800  -22.1200
            4   O7x O    26.8800  -20.6500
            5   C1x C    24.6400  -20.6500
            6   C1y C    24.5000  -23.4500
            7   C1x C    23.3800  -21.4200
            8   C1a C    23.8700  -20.5800
            9   C1x C    26.8800  -23.4500
            10  C7x C    26.4600  -19.3200
            11  C1x C    25.0600  -19.3200
            12  C1y C    23.3800  -24.1500
            13  C1y C    22.1900  -22.1200
            14  O6a O    27.2300  -18.2700
            15  C1z C    22.1900  -23.4500
            16  C1y C    23.3800  -25.5500
            17  C1z C    21.0000  -24.1500
            18  C1x C    22.1900  -26.1800
            19  C7a C    24.5000  -26.1800
            20  C2y C    21.0000  -25.4800
            21  C1x C    19.8100  -23.4500
            22  C1a C    21.0000  -22.7500
            23  O7a O    25.6900  -25.5500
            24  C2x C    19.8100  -26.1800
            25  C1x C    18.6200  -24.1500
            26  C1a C    26.8800  -26.1800
            27  C5x C    18.6200  -25.4800
            28  O5x O    17.4300  -26.1800
            29  O6a O    24.5000  -27.5800
            30  O2x O    23.4024  -22.8200
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Down
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 1
            13   10  14 2
            14   12  15 1
            15   12  16 1
            16   15  17 1
            17   16  18 1
            18   16  19 1 #Down
            19   17  20 1
            20   17  21 1
            21   17  22 1 #Up
            22   19  23 1
            23   20  24 2
            24   21  25 1
            25   23  26 1
            26   24  27 1
            27   27  28 2
            28    6   9 1
            29   10  11 1
            30   13  15 1
            31   18  20 1
            32   25  27 1
            33   19  29 2
            34   13  30 1 #Down
            35   15  30 1 #Down

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