KEGG   DRUG: Rebamipide
Entry
D01121                      Drug                                   
Name
Rebamipide (JP18/INN);
Mucosta (TN)
Formula
C19H15ClN2O4
Exact mass
370.072
Mol weight
370.7864
Structure
Class
Gastrointestinal agent
 DG01975  Agents for peptic ulcer
  DG02008  Gastric mucosal protectant
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1319 2329
ATC code: A02BX14
Product: D01121<JP>
Efficacy
Anti-ulcerative, Mucin production accelerator
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07038  Antiulcer drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BX Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
     A02BX14 Rebamipide
      D01121  Rebamipide (JP18/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01121  Rebamipide (JP18/INN)
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2329  Others
     D01121  Rebamipide (JP18/INN)
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01975  Agents for peptic ulcer
   DG02008  Gastric mucosal protectant
    D01121  Rebamipide
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D01121  Rebamipide
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01121  Rebamipide
  D01121  Rebamipide tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01121
Other DBs
CAS: 111911-87-6
PubChem: 7848184
ChEBI: 32090 93814
LigandBox: D01121
KCF data

ATOM        26
            1   C8x C    18.6833  -23.6491
            2   C8x C    18.6833  -22.2477
            3   C8x C    19.8999  -21.5470
            4   C8x C    19.8999  -24.3498
            5   C8y C    21.0393  -23.6491
            6   C8y C    21.1034  -22.2477
            7   C8y C    22.3140  -21.5417
            8   C8x C    23.5306  -22.2373
            9   C8y C    23.5366  -23.6387
            10  N4x N    22.3259  -24.3446
            11  O5x O    24.7532  -24.3342
            12  C1b C    22.3081  -20.1403
            13  C1c C    23.5174  -19.4449
            14  N1b N    24.7277  -20.1456
            15  C5a C    25.9380  -19.4449
            16  C8y C    27.1483  -20.1456
            17  C8x C    28.3603  -19.4477
            18  C8x C    29.5707  -20.1485
            19  C8y C    29.5690  -21.5470
            20  C8x C    28.3569  -22.2448
            21  C8x C    27.1466  -21.5441
            22  X   Cl   30.7818  -22.2491
            23  O5a O    25.9380  -18.0434
            24  C6a C    23.5194  -18.0434
            25  O6a O    22.3067  -17.3409
            26  O6a O    24.7342  -17.3444
BOND        28
            1     2   3 1
            2    12  13 1
            3     3   6 2
            4    13  14 1
            5     5   4 2
            6    14  15 1
            7     4   1 1
            8    15  16 1
            9     5   6 1
            10    6   7 1
            11    7   8 2
            12    8   9 1
            13    9  10 1
            14   16  17 2
            15   17  18 1
            16   18  19 2
            17   19  20 1
            18   20  21 2
            19   21  16 1
            20   10   5 1
            21   19  22 1
            22   15  23 2
            23    9  11 2
            24   13  24 1
            25    1   2 2
            26   24  25 1
            27    7  12 1
            28   24  26 2

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