KEGG   DRUG: Ramatroban
Entry
D01128                      Drug                                   
Name
Ramatroban (JAN/INN);
Baynas (TN)
Formula
C21H21FN2O4S
Exact mass
416.1206
Mol weight
416.4658
Structure
Class
Anti-allergic agent
 DG01517  Thromboxane A2 receptor antagonist
Remark
Therapeutic category: 4490
Product: D01128<JP>
Efficacy
Antiallergic, Antiasthmatic, Anti-inflammatory, Thromboxane A2 (TXA2) receptor antagonist, Prostaglandin D receptor antagonist
Target
TBXA2R [HSA:6915] [KO:K04264]
PTGDR [HSA:5729] [KO:K04332]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07034  Eicosanoids
map07228  Eicosanoid receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D01128  Ramatroban (JAN/INN)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01517  Thromboxane A2 receptor antagonist
   D01128  Ramatroban
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostaglandin
    PTGDR
     D01128  Ramatroban (JAN/INN) <JP>
   Thromboxane
    TBXA2R
     D01128  Ramatroban (JAN/INN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01128
Other DBs
CAS: 116649-85-5
PubChem: 7848191
ChEBI: 32087
PDB-CCD: A8X[PDBj]
LigandBox: D01128
NIKKAJI: J388.276D
KCF data

ATOM        29
            1   C1b C    29.1759  -17.4458
            2   C1b C    30.5733  -17.4458
            3   N4y N    28.4773  -18.6560
            4   C6a C    31.2719  -16.2357
            5   C1y C    24.7942  -20.6074
            6   C1x C    24.7937  -19.2163
            7   C1x C    25.9979  -18.5205
            8   C8y C    27.2029  -19.2155
            9   C8y C    27.2034  -20.6064
            10  C1x C    25.9990  -21.3023
            11  C8x C    29.3958  -22.1157
            12  C8x C    30.7989  -19.6999
            13  C8x C    31.4942  -20.9119
            14  C8x C    30.7957  -22.1180
            15  C8y C    29.4053  -19.6940
            16  C8y C    28.7034  -20.8972
            17  N1b N    23.5843  -21.3064
            18  S4a S    22.3740  -20.6082
            19  C8y C    21.1640  -21.3074
            20  C8x C    19.9601  -20.6089
            21  C8x C    18.7502  -21.3081
            22  C8y C    18.7507  -22.7054
            23  C8x C    19.9611  -23.4036
            24  C8x C    21.1709  -22.7044
            25  X   F    17.5409  -23.4044
            26  O6a O    32.6693  -16.2357
            27  O6a O    30.5733  -15.0255
            28  O3c O    21.1616  -19.9082
            29  O3c O    23.5864  -19.9082
BOND        32
            1     5   6 1
            2     6   7 1
            3    15  16 1
            4    16   9 1
            5     8   3 1
            6     3  15 1
            7     7   8 1
            8     5  17 1 #Down
            9     8   9 2
            10   17  18 1
            11    9  10 1
            12   18  19 1
            13   10   5 1
            14    1   2 1
            15    2   4 1
            16    1   3 1
            17   11  16 2
            18   15  12 2
            19   19  20 2
            20   20  21 1
            21   21  22 2
            22   22  23 1
            23   23  24 2
            24   24  19 1
            25   12  13 1
            26   22  25 1
            27   13  14 2
            28    4  26 1
            29   14  11 1
            30    4  27 2
            31   18  28 2
            32   18  29 2

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (4)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
   PDB-CCD (1)   
Gene (4)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (2)   
All databases (17)   

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