| Entry |
|
|---|
| Name |
Tolterodine tartrate (JAN/USP);
Detrol (TN);
Detrusitol (TN) |
|---|
| Product |
|
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| Generic |
TOLTERODINE TARTRATE (A-S Medication Solutions), TOLTERODINE TARTRATE (ANI Pharmaceuticals), TOLTERODINE TARTRATE (Ajanta Pharma USA), TOLTERODINE TARTRATE (American Health Packaging), TOLTERODINE TARTRATE (Athem LLC), TOLTERODINE TARTRATE (Camber Pharmaceuticals), TOLTERODINE TARTRATE (Camber Pharmaceuticals), TOLTERODINE TARTRATE (Drug Ocean LLC), TOLTERODINE TARTRATE (Golden State Medical Supply), TOLTERODINE TARTRATE (Greenstone LLC), TOLTERODINE TARTRATE (Macleods Pharmaceuticals Limited), TOLTERODINE TARTRATE (Major Pharmaceuticals), TOLTERODINE TARTRATE (Proficient Rx LP), TOLTERODINE TARTRATE (Rising Pharma Holdings), TOLTERODINE TARTRATE (Slate Run Pharmaceuticals), TOLTERODINE TARTRATE (Teva Pharmaceuticals USA), TOLTERODINE TARTRATE (Teva Pharmaceuticals USA), TOLTERODINE TARTRATE (Torrent Pharmaceuticals Limited), TOLTERODINE TARTRATE (Unichem Pharmaceuticals (USA)), TOLTERODINE TARTRATE EXTENDED RELEASE (Greenstone LLC) |
|---|
| Formula |
C22H31NO. C4H6O6
|
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| Exact mass |
475.257
|
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| Mol weight |
475.5745
|
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| Structure |
|
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| Class |
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 2590 |
| Product (DG00480): | D01148<JP/US> |
|
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| Efficacy |
Overactive bladder agent, Muscarinic acetylcholine receptor antagonist |
|---|
| Comment |
Treatment of urinary incontinence
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04B UROLOGICALS
G04BD Drugs for urinary frequency and incontinence
G04BD07 Tolterodine
D01148 Tolterodine tartrate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Genitourinary Agents
Antispasmodics, Urinary
Cholinergic Muscarinic Antagonists
Tolterodine
D01148 Tolterodine tartrate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
25 Urogenital and anal organ agents
259 Miscellaneous
2590 Miscellaneous
D01148 Tolterodine tartrate (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG00480 Tolterodine
D01148 Tolterodine tartrate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00480 Tolterodine
D01148 Tolterodine tartrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00480 Tolterodine
D01148 Tolterodine tartrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM3
D01148 Tolterodine tartrate (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01148
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01148
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D01148
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG00480 Tolterodine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00480 Tolterodine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00480 Tolterodine
|
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| Other DBs |
|
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| KCF data |
ATOM 34
1 O6a O 22.5567 -17.4447
2 C6a C 23.7680 -16.7435
3 C1c C 24.9791 -17.4447
4 C1c C 26.1905 -16.7435
5 C6a C 27.4018 -17.4447
6 O6a O 28.6130 -16.7435
7 O6a O 23.7680 -15.3410
8 O1a O 24.9791 -18.8472
9 O1a O 26.1905 -15.3410
10 O6a O 27.4018 -18.8472
11 C1c C 9.8068 -16.8754
12 N1c N 11.0205 -17.5762
13 C1b C 12.2344 -16.8754
14 C1b C 13.4481 -17.5762
15 C1c C 14.6618 -16.8754
16 C8y C 15.8756 -17.5762
17 C8x C 17.0894 -16.8754
18 C8y C 18.3032 -17.5762
19 C1a C 19.5170 -16.8754
20 C1a C 8.5930 -17.5762
21 C1a C 9.8068 -15.4739
22 C1c C 11.0205 -18.9775
23 C1a C 9.7899 -19.6882
24 C1a C 12.2175 -19.6687
25 C8y C 14.6618 -15.4740
26 C8y C 15.8756 -18.9774
27 C8x C 18.3032 -18.9776
28 C8x C 17.1102 -19.6905
29 O1a O 14.6827 -19.6663
30 C8x C 15.8607 -14.7817
31 C8x C 15.8606 -13.3802
32 C8x C 14.6468 -12.6795
33 C8x C 13.4479 -13.3718
34 C8x C 13.4480 -14.7733
BOND 34
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 2 7 2
7 3 8 1 #Up
8 4 9 1 #Up
9 5 10 2
10 11 12 1
11 12 13 1
12 13 14 1
13 15 14 1 #Down
14 15 16 1
15 16 17 1
16 17 18 2
17 18 19 1
18 11 20 1
19 11 21 1
20 12 22 1
21 22 23 1
22 22 24 1
23 15 25 1
24 16 26 2
25 18 27 1
26 26 28 1
27 28 27 2
28 26 29 1
29 25 30 2
30 30 31 1
31 31 32 2
32 32 33 1
33 33 34 2
34 25 34 1
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