KEGG   DRUG: Oxethazaine
Entry
D01152                      Drug                                   
Name
Oxethazaine (JP18/USAN);
Oxetacaine (INN);
Strocain (TN)
Formula
C28H41N3O3
Exact mass
467.3148
Mol weight
467.6434
Structure
Simcomp
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01673  Amide type local anesthetic
Gastrointestinal agent
 DG01975  Agents for peptic ulcer
Remark
Same as: C12552
Therapeutic category: 1219
ATC code: C05AD06
Chemical structure group: DG00299
Product (DG00299): D01152<JP>
Efficacy
Anesthetic (local), Anti-ulcerative
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07038  Antiulcer drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD06 Oxetacaine
      D01152  Oxethazaine (JP18/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1219  Others
     D01152  Oxethazaine (JP18/USAN); Oxetacaine (INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for digestive organs
  15 Stomach pain and cramp relievers
   D01152  Oxethazaine (JP18/USAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Oxethazaine
    D01152  Oxethazaine (JP18/USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01673  Amide type local anesthetic
     DG00299  Oxetacaine
      D01152  Oxethazaine
 Gastrointestinal agent
  DG01975  Agents for peptic ulcer
   DG00299  Oxetacaine
    D01152  Oxethazaine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D01152  Oxethazaine (JP18/USAN) <JP>
    SCN2A
     D01152  Oxethazaine (JP18/USAN) <JP>
    SCN3A
     D01152  Oxethazaine (JP18/USAN) <JP>
    SCN4A
     D01152  Oxethazaine (JP18/USAN) <JP>
    SCN5A
     D01152  Oxethazaine (JP18/USAN) <JP>
    SCN8A
     D01152  Oxethazaine (JP18/USAN) <JP>
    SCN9A
     D01152  Oxethazaine (JP18/USAN) <JP>
    SCN10A
     D01152  Oxethazaine (JP18/USAN) <JP>
    SCN11A
     D01152  Oxethazaine (JP18/USAN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01152  Oxethazaine
Rx-to-OTC switch list in Japan [br08314.html]
 D01152
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01673  Amide type local anesthetic
     DG00299  Oxetacaine
 Gastrointestinal agent
  DG01975  Agents for peptic ulcer
   DG00299  Oxetacaine
Other DBs
CAS: 126-27-2
PubChem: 7848215
ChEBI: 31947
LigandBox: D01152
NIKKAJI: J2.510K
KCF data

ATOM        34
            1   N1c N    22.2607  -16.9888
            2   C1b C    20.8526  -16.9816
            3   C1b C    22.9710  -15.5628
            4   C5a C    24.4501  -15.5700
            5   N1c N    25.0893  -14.3540
            6   C1d C    26.4975  -14.3612
            7   C1a C    24.3914  -13.1311
            8   C1b C    27.2077  -13.1452
            9   C1a C    26.5552  -15.9089
            10  C1a C    27.7083  -15.0648
            11  C8y C    28.6157  -13.1524
            12  C8x C    29.3094  -14.3771
            13  C8x C    30.7175  -14.3843
            14  C8x C    31.4277  -13.1683
            15  C8x C    30.7298  -11.9452
            16  C8x C    29.3216  -11.9382
            17  C1b C    20.1546  -15.7587
            18  O1a O    18.7465  -15.7515
            19  C1b C    22.9587  -18.4218
            20  C5a C    24.3658  -18.4149
            21  N1c N    25.0758  -19.6309
            22  C1d C    26.4840  -19.6241
            23  C1b C    27.1940  -20.8400
            24  C1a C    24.3777  -20.8539
            25  C1a C    26.4709  -17.7957
            26  C1a C    27.6942  -18.9128
            27  C8y C    28.6022  -20.8332
            28  C8x C    29.3075  -22.0517
            29  C8x C    30.7156  -22.0447
            30  C8x C    31.4137  -20.8218
            31  C8x C    30.7037  -19.6058
            32  C8x C    29.2955  -19.6126
            33  O5a O    25.3686  -16.4233
            34  O5a O    25.2904  -17.5543
BOND        35
            1     2  17 1
            2     6   9 1
            3    17  18 1
            4     4   5 1
            5     1  19 1
            6     6  10 1
            7    19  20 1
            8     1   3 1
            9    20  21 1
            10    8  11 1
            11   21  22 1
            12    5   6 1
            13   22  23 1
            14    1   2 1
            15   21  24 1
            16    5   7 1
            17   22  25 1
            18    3   4 1
            19   22  26 1
            20    6   8 1
            21   23  27 1
            22   11  12 2
            23   12  13 1
            24   13  14 2
            25   14  15 1
            26   15  16 2
            27   27  28 2
            28   28  29 1
            29   29  30 2
            30   30  31 1
            31   31  32 2
            32   32  27 1
            33   16  11 1
            34    4  33 2
            35   20  34 2

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