KEGG   DRUG: Blonanserin
Entry
D01176                      Drug                                   
Name
Blonanserin (JAN/INN);
AD 5423
Formula
C23H30FN3
Exact mass
367.2424
Mol weight
367.5028
Structure
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
 DG03200  Antipsychotic agent
  DG03064  Atypical antipsychotic
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1179
Product: D01176<JP>
Efficacy
Antipsychotic
Target
HTR2A [HSA:3356] [KO:K04157]
DRD2 [HSA:1813] [KO:K04145]
DRD3 [HSA:1814] [KO:K04146]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01176  Blonanserin (JAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   D01176  Blonanserin
  DG03200  Antipsychotic agent
   DG03064  Atypical antipsychotic
    D01176  Blonanserin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D01176  Blonanserin
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D01176  Blonanserin (JAN/INN) <JP>
    DRD3
     D01176  Blonanserin (JAN/INN) <JP>
   Serotonin
    HTR2A
     D01176  Blonanserin (JAN/INN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01176
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01176
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01176
Other DBs
CAS: 132810-10-7
PubChem: 7848239
ChEBI: 31296
LigandBox: D01176
KCF data

ATOM        27
            1   C8y C    18.6615  -14.9275
            2   C8y C    18.6615  -16.3259
            3   C8y C    19.8755  -17.0251
            4   C8x C    21.0824  -16.3259
            5   C8y C    21.0824  -14.9275
            6   N5x N    19.8755  -14.2283
            7   C1x C    17.6737  -17.3297
            8   C1x C    16.2651  -17.3297
            9   C1x C    17.6737  -13.9339
            10  C1x C    15.2715  -16.3301
            11  C1x C    16.2651  -13.9339
            12  C1x C    15.2715  -14.9275
            13  N1y N    22.2940  -14.2292
            14  C8y C    19.8772  -18.4235
            15  C8x C    18.6681  -19.1227
            16  C8x C    18.6698  -20.5211
            17  C8y C    19.8818  -21.2187
            18  C8x C    21.0920  -20.5180
            19  C8x C    21.0902  -19.1196
            20  X   F    19.8836  -22.6171
            21  C1x C    23.5010  -14.9299
            22  C1x C    24.7126  -14.2315
            23  N1y N    24.7136  -12.8331
            24  C1x C    23.5032  -12.1331
            25  C1x C    22.2916  -12.8313
            26  C1b C    25.9252  -12.1348
            27  C1a C    27.1358  -12.8350
BOND        30
            1     5  13 1
            2     3  14 1
            3     1   2 2
            4     2   3 1
            5     3   4 2
            6     4   5 1
            7     5   6 2
            8    14  15 2
            9    15  16 1
            10   16  17 2
            11   17  18 1
            12   18  19 2
            13   19  14 1
            14    2   7 1
            15   17  20 1
            16    7   8 1
            17    1   9 1
            18    8  10 1
            19    9  11 1
            20   10  12 1
            21   13  21 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   24  25 1
            26   25  13 1
            27   11  12 1
            28   23  26 1
            29    6   1 1
            30   26  27 1

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Ontology (6)   
   KEGG BRITE (6)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (4)   
   KEGG DGROUP (3)   
   LigandBox (1)   
Chemical substance (2)   
   PubChem (1)   
   ChEBI (1)   
Gene (6)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (3)   
All databases (19)   

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