KEGG   DRUG: Duloxetine hydrochloride
Entry
D01179                      Drug                                   
Name
Duloxetine hydrochloride (JAN/USP);
Cymbalta (TN);
Yentreve (TN)
Product
CYMBALTA (Eli Lilly and Company), DRIZALMA SPRINKLE (SUN PHARMACEUTICAL INDUSTRIES)
  Generic
DULOXETINE (A-S Medication Solutions), DULOXETINE (A-S Medication Solutions), DULOXETINE (A-S Medication Solutions), DULOXETINE (A-S Medication Solutions), DULOXETINE (A-S Medication Solutions), DULOXETINE (A-S Medication Solutions), DULOXETINE (A-S Medication Solutions), DULOXETINE (A-S Medication Solutions), DULOXETINE (A-S Medication Solutions), DULOXETINE (A-S Medication Solutions), DULOXETINE (A-S Medication Solutions), DULOXETINE (Actavis Pharma), DULOXETINE (Advanced Rx Pharmacy of Tennessee), DULOXETINE (Advanced Rx Pharmacy of Tennessee), DULOXETINE (Ajanta Pharma USA), DULOXETINE (American Health Packaging), DULOXETINE (American Health Packaging), DULOXETINE (Aphena Pharma Solutions - Tennessee), DULOXETINE (Aphena Pharma Solutions - Tennessee), DULOXETINE (Aphena Pharma Solutions - Tennessee), DULOXETINE (Aphena Pharma Solutions - Tennessee), DULOXETINE (Aphena Pharma Solutions - Tennessee), DULOXETINE (Aphena Pharma Solutions - Tennessee), DULOXETINE (Aphena Pharma Solutions - Tennessee), DULOXETINE (Ascend Laboratories), DULOXETINE (Asclemed USA), DULOXETINE (Asclemed USA), DULOXETINE (Aurobindo Pharma Limited), DULOXETINE (AvPAK), DULOXETINE (BluePoint Laboratories), DULOXETINE (BluePoint Laboratories), DULOXETINE (BluePoint), DULOXETINE (Breckenridge Pharmaceutical), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Bryant Ranch Prepack), DULOXETINE (Camber Pharmaceuticals), DULOXETINE (Camber Pharmaceuticals), DULOXETINE (Cardinal Health 107), DULOXETINE (Cardinal Health 107), DULOXETINE (Cardinal Health 107), DULOXETINE (DIRECT RX), DULOXETINE (Direct_Rx), DULOXETINE (Golden State Medical Supply), DULOXETINE (Golden State Medical Supply), DULOXETINE (Inventia Healthcare Private Limited), DULOXETINE (Lupin Pharmaceuticals), DULOXETINE (MARKSANS PHARMA LIMITED), DULOXETINE (Major Pharmaceuticals), DULOXETINE (Medsource Pharmaceuticals), DULOXETINE (NCS HealthCare of KY), DULOXETINE (Northwind Pharmaceuticals), DULOXETINE (NuCare Pharmaceuticals), DULOXETINE (NuCare Pharmaceuticals), DULOXETINE (NuCare Pharmaceuticals), DULOXETINE (PD-Rx Pharmaceuticals), DULOXETINE (PD-Rx Pharmaceuticals), DULOXETINE (PD-Rx Pharmaceuticals), DULOXETINE (Preferred Pharmaceuticals), DULOXETINE (Preferred Pharmaceuticals), DULOXETINE (Preferred Pharmaceuticals), DULOXETINE (Preferred Pharmaceuticals), DULOXETINE (Preferred Pharmaceuticals), DULOXETINE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE (Proficient Rx LP), DULOXETINE (Quality Care Products LLC), DULOXETINE (Quality Care Products LLC), DULOXETINE (Quality Care Products), DULOXETINE (Quality Care Products), DULOXETINE (Quallent Pharmaceuticals Health), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (REMEDYREPACK), DULOXETINE (RPK Pharmaceuticals), DULOXETINE (RPK Pharmaceuticals), DULOXETINE (Rising Pharma Holdings), DULOXETINE (ST. MARY'S MEDICAL PARK PHARMACY), DULOXETINE (ST. MARY'S MEDICAL PARK PHARMACY), DULOXETINE (Solco Healthcare US), DULOXETINE (St. Mary's Medical Park Pharmacy), DULOXETINE (St. Mary's Medical Park Pharmacy), DULOXETINE (Sun Pharmaceutical Industries), DULOXETINE (Zydus Lifesciences Limited), DULOXETINE (Zydus Lifesciences Limited), DULOXETINE (Zydus Pharmaceuticals (USA)), DULOXETINE (Zydus Pharmaceuticals USA), DULOXETINE (medsource pharmaceuticals), DULOXETINE HCL (Advanced Rx Pharmacy of Tennessee), DULOXETINE HCL (Advanced Rx Pharmacy of Tennessee), DULOXETINE HCL (Advanced Rx Pharmacy of Tennessee), DULOXETINE HCL (Advanced Rx Pharmacy of Tennessee), DULOXETINE HCL (Advanced Rx Pharmacy of Tennessee), DULOXETINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), DULOXETINE HYDROCHLORIDE (DIRECT RX), DULOXETINE HYDROCHLORIDE (Direct_Rx), DULOXETINE HYDROCHLORIDE (Macleods Pharmaceuticals Limited), DULOXETINE HYDROCHLORIDE (NCS HealthCare of KY), DULOXETINE HYDROCHLORIDE (NCS HealthCare of KY), DULOXETINE HYDROCHLORIDE (Proficient Rx LP), DULOXETINE HYDROCHLORIDE (Proficient Rx LP), DULOXETINE HYDROCHLORIDE (Proficient Rx LP), DULOXETINE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), NA (Qingdao BAHEAL Pharmaceutical)
Formula
C18H19NOS. HCl
Exact mass
333.0954
Mol weight
333.8755
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01658  Serotonin and norepinephrine reuptake inhibitor (SNRI)
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 1179 1190
ATC code: N06AX21
Chemical structure group: DG00962
Product (DG00962): D01179<JP/US>
Efficacy
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
  Disease
Major depressive disorder [DS:H01646]
Generalized anxiety disorder [DS:H01662]
Diabetic peripheral neuropathic pain [DS:H01459]
Fibromyalgia [DS:H01636]
Comment
Fluoxetine derivative
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544]; CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX21 Duloxetine
      D01179  Duloxetine hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Duloxetine
    D01179  Duloxetine hydrochloride (JAN/USP)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Duloxetine
    D01179  Duloxetine hydrochloride (JAN/USP)
 Central Nervous System Agents
  Fibromyalgia Agents
   Duloxetine
    D01179  Duloxetine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01179  Duloxetine hydrochloride (JAN/USP)
   119  Miscellaneous
    1190  Miscellaneous
     D01179  Duloxetine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01658  Serotonin and norepinephrine reuptake inhibitor (SNRI)
   DG00962  Duloxetine
    D01179  Duloxetine hydrochloride
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00962  Duloxetine
    D01179  Duloxetine hydrochloride
  DG01644  CYP2D6 substrate
   DG00962  Duloxetine
    D01179  Duloxetine hydrochloride
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00962  Duloxetine
    D01179  Duloxetine hydrochloride
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D01179  Duloxetine hydrochloride (JAN/USP) <JP/US>
    SLC6A4 (HTT)
     D01179  Duloxetine hydrochloride (JAN/USP) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01179
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01179
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01179
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01179
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01179
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D01179
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01658  Serotonin and norepinephrine reuptake inhibitor (SNRI)
   DG00962  Duloxetine
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00962  Duloxetine
  DG01644  CYP2D6 substrate
   DG00962  Duloxetine
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00962  Duloxetine
Other DBs
CAS: 136434-34-9
PubChem: 7848242
ChEBI: 31526
LigandBox: D01179
KCF data

ATOM        22
            1   S2x S    17.1214  -19.0627
            2   C8x C    15.9783  -19.8891
            3   C8x C    16.4140  -21.2272
            4   C8x C    17.8216  -21.2272
            5   C8y C    18.2576  -19.8891
            6   C1c C    19.4627  -19.1831
            7   C1b C    20.6722  -19.8833
            8   C1b C    21.8817  -19.1831
            9   N1b N    23.0912  -19.8833
            10  C1a C    24.3007  -19.1831
            11  O2a O    19.4589  -17.7826
            12  C8y C    20.6699  -17.0791
            13  C8x C    21.8781  -17.7788
            14  C8x C    23.0891  -17.0756
            15  C8x C    23.0856  -15.6751
            16  C8y C    20.6599  -15.6814
            17  C8y C    21.8696  -14.9832
            18  C8x C    21.8698  -13.5864
            19  C8x C    20.6603  -12.8879
            20  C8x C    19.4506  -13.5861
            21  C8x C    19.4504  -14.9828
            22  X   Cl   27.5966  -17.5067
BOND        23
            1     4   5 2
            2     6  11 1 #Up
            3     5   1 1
            4    11  12 1
            5     2   3 2
            6     5   6 1
            7    12  13 2
            8    13  14 1
            9    14  15 2
            10   15  17 1
            11   16  12 1
            12    6   7 1
            13    7   8 1
            14    1   2 1
            15    8   9 1
            16    3   4 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   21  16 1
            23    9  10 1

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