| Entry |
|
|---|
| Name |
Alprenolol hydrochloride (JP18/USAN);
Regletin (TN) |
|---|
| Formula |
C15H23NO2. HCl
|
|---|
| Exact mass |
285.1496
|
|---|
| Mol weight |
285.8096
|
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| Structure |
|
|---|
| Simcomp |
|
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
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| Remark |
|
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| Efficacy |
Antiarrhythmic, beta-Adrenergic receptor antagonist |
|---|
| Comment |
Propranolol derivative
|
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| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07214 | beta-Adrenergic receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AA Beta blocking agents, non-selective
C07AA01 Alprenolol
D01182 Alprenolol hydrochloride (JP18/USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG00303 Alprenolol
D01182 Alprenolol hydrochloride
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00303 Alprenolol
D01182 Alprenolol hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00303 Alprenolol
D01182 Alprenolol hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB
D01182 Alprenolol hydrochloride (JP18/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01182 Alprenolol hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01182
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG00303 Alprenolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00303 Alprenolol
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00303 Alprenolol
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 19
1 C1b C 12.2500 -5.1800
2 C1c C 13.4400 -5.8800
3 C1b C 14.6300 -5.1800
4 N1b N 15.8200 -5.8800
5 C1c C 17.0800 -5.1800
6 C1a C 18.2700 -5.8800
7 O2a O 10.9900 -5.8800
8 O1a O 13.4400 -7.2800
9 C1a C 17.0800 -3.7800
10 C8y C 10.9900 -7.2800
11 C8y C 9.7776 -7.9800
12 C8x C 9.7776 -9.3800
13 C8x C 10.9900 -10.0800
14 C8x C 12.2024 -9.3800
15 C8x C 12.2024 -7.9800
16 C1b C 8.5821 -7.2896
17 C2b C 7.3947 -7.9751
18 C2a C 7.3947 -9.3751
19 X Cl 16.8000 -9.1700
BOND 18
1 2 3 1
2 3 4 1
3 4 5 1
4 5 6 1
5 2 8 1
6 7 1 1
7 5 9 1
8 1 2 1
9 7 10 1
10 10 11 2
11 11 12 1
12 12 13 2
13 13 14 1
14 14 15 2
15 10 15 1
16 11 16 1
17 16 17 1
18 17 18 2
|
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