KEGG   DRUG: Febuxostat
Entry
D01206                      Drug                                   
Name
Febuxostat (JAN/USAN/INN);
Uloric (TN);
Feburic (TN)
Product
ULORIC (Takeda Pharmaceuticals America)
  Generic
FEBUXOSTAT (Alembic Pharmaceuticals Limited), FEBUXOSTAT (Alembic Pharmaceuticals), FEBUXOSTAT (American Health Packaging), FEBUXOSTAT (Ascend Laboratories), FEBUXOSTAT (Aurobindo Pharma Limited), FEBUXOSTAT (DR REDDY'S LABORATORIES LIMITED), FEBUXOSTAT (Lannett Company), FEBUXOSTAT (MAJOR PHARMACEUTICALS), FEBUXOSTAT (Macleods Pharmaceuticals Limited), FEBUXOSTAT (NorthStar RxLLC), FEBUXOSTAT (NuCare Pharmaceuticals), FEBUXOSTAT (Solco Healthcare US LLC), FEBUXOSTAT (Sun Pharmaceutical Industries), FEBUXOSTAT (Viona Pharmaceuticals), FEBUXOSTAT (Zydus Lifesciences Limited)
Formula
C16H16N2O3S
Exact mass
316.0882
Mol weight
316.3748
Structure
Class
Cardiovascular agent
 DG01503  Xanthine dehydrogenase inhibitor
Musculo-skeletal system agent
 DG03130  Xanthin oxidase inhibitor
Remark
Therapeutic category: 3949
ATC code: M04AA03
Chemical structure group: DG02878
Product (DG02878): D01206<JP/US> D11081<JP/US>
Efficacy
Gout suppressant, Uric acid biosynthesis inhibitor, Xanthine oxidase inhibitor
  Disease
Gout [DS:H01532]
Comment
Management of hyperuricemia in patients with gout
Target
XDH [HSA:7498] [KO:K00106]
  Pathway
hsa00230  Purine metabolism
hsa04146  Peroxisome
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M04 ANTIGOUT PREPARATIONS
   M04A ANTIGOUT PREPARATIONS
    M04AA Preparations inhibiting uric acid production
     M04AA03 Febuxostat
      D01206  Febuxostat (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antigout Agents
  Febuxostat
   D01206  Febuxostat (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   394  Gout preparations
    3949  Others
     D01206  Febuxostat (JAN/USAN/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01503  Xanthine dehydrogenase inhibitor
   DG02878  Febuxostat
    D01206  Febuxostat
 Musculo-skeletal system agent
  DG03130  Xanthin oxidase inhibitor
   DG02878  Febuxostat
    D01206  Febuxostat
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Xanthine dehydrogenase/oxidase
    XDH
     D01206  Febuxostat (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01206
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01206
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01206
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01206
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01503  Xanthine dehydrogenase inhibitor
   DG02878  Febuxostat
 Musculo-skeletal system agent
  DG03130  Xanthin oxidase inhibitor
   DG02878  Febuxostat
Other DBs
CAS: 144060-53-7
PubChem: 7848269
ChEBI: 31596
PDB-CCD: TEI[PDBj]
LigandBox: D01206
KCF data

ATOM        22
            1   C8x C    16.2448  -15.8562
            2   C8y C    16.2448  -17.2564
            3   C8y C    17.4603  -17.9563
            4   C8x C    18.6686  -17.2564
            5   C8y C    18.6686  -15.8562
            6   C8x C    17.4603  -15.1562
            7   C8y C    19.8816  -15.1570
            8   C3b C    17.4620  -19.3565
            9   O2a O    15.0325  -17.9569
            10  C1b C    13.8197  -17.2575
            11  C1c C    12.6075  -17.9582
            12  C1a C    11.3946  -17.2587
            13  C1a C    12.6082  -19.3584
            14  S2x S    21.2083  -15.5955
            15  C8y C    22.0380  -14.4677
            16  C8y C    21.2218  -13.3302
            17  N5x N    19.8877  -13.7548
            18  C1a C    21.6625  -12.0012
            19  C6a C    23.4381  -14.4761
            20  O6a O    24.1311  -15.6927
            21  O6a O    24.1455  -13.2676
            22  N3a N    17.4539  -20.7566
BOND        23
            1     9  10 1
            2     5   6 2
            3    10  11 1
            4     6   1 1
            5    11  12 1
            6    11  13 1
            7     5   7 1
            8     1   2 2
            9     3   8 1
            10    2   3 1
            11    7  14 1
            12   14  15 1
            13   15  16 2
            14   16  17 1
            15   17   7 2
            16   16  18 1
            17    3   4 2
            18   15  19 1
            19    2   9 1
            20   19  20 2
            21    4   5 1
            22   19  21 1
            23    8  22 3

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Ontology (9)   
   KEGG BRITE (9)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   PDB-CCD (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
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