KEGG   DRUG: Distigmine bromide
Entry
D01228                      Drug                                   
Name
Distigmine bromide (JP18/INN);
Ubretid (TN)
Formula
C22H32N4O4. 2Br
Exact mass
574.079
Mol weight
576.3219
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
 DG01719  Parasympathomimetic agent
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Remark
Therapeutic category: 1231 1312
ATC code: N07AA03
Chemical structure group: DG00989
Product (DG00989): D01228<JP>
Efficacy
Acetylcholinesterase inhibitor
Comment
Quaternary ammonium compound
Target
ACHE [HSA:43] [KO:K01049]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse
Interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AA Anticholinesterases
     N07AA03 Distigmine
      D01228  Distigmine bromide (JP18/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   123  Autonomic nervous system agents
    1231  Quaternary ammoniums
     D01228  Distigmine bromide (JP18/INN)
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1312  Miotic agents
     D01228  Distigmine bromide (JP18/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00989  Distigmine
     D01228  Distigmine bromide
  DG01719  Parasympathomimetic agent
   DG00989  Distigmine
    D01228  Distigmine bromide
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D01228  Distigmine bromide
Drug classes [BR:br08332]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D01228  Distigmine bromide
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Carboxylic-ester hydrolases
    ACHE
     D01228  Distigmine bromide (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01228  Distigmine bromide
  D01228  Distigmine bromide tablets
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00989  Distigmine
  DG01719  Parasympathomimetic agent
   DG00989  Distigmine
Other DBs
CAS: 15876-67-2
PubChem: 7848291
ChEBI: 31512
LigandBox: D01228
NIKKAJI: J231.100C
KCF data

ATOM        32
            1   X   Br   10.8112  -13.6523 #-
            2   X   Br   32.7804  -20.1826 #-
            3   C8y C    29.7353  -17.3380
            4   C8x C    29.7284  -18.7366
            5   N5y N    30.9361  -19.4420 #+
            6   C8x C    32.1507  -18.7488
            7   C8x C    32.1578  -17.3503
            8   C8x C    30.9502  -16.6449
            9   C8y C    14.0147  -16.7005
            10  O7a O    15.2248  -17.3903
            11  C8x C    14.0147  -15.2917
            12  C8x C    12.7989  -17.3962
            13  C7a C    16.4406  -16.6947
            14  N5y N    12.7989  -14.5844 #+
            15  C8x C    11.5772  -16.7005
            16  N1c N    17.6566  -17.3845
            17  O6a O    16.4348  -15.2800
            18  C8x C    11.5772  -15.2917
            19  C1a C    12.8047  -13.1816
            20  C1b C    18.8667  -16.6771
            21  C1a C    17.6566  -18.7875
            22  C1b C    20.0796  -17.3662
            23  C1b C    21.2803  -16.6669
            24  C1b C    22.4953  -17.3592
            25  C1b C    23.6960  -16.6599
            26  C1b C    24.9110  -17.3521
            27  N1c N    26.1117  -16.6529
            28  C7a C    27.3267  -17.3450
            29  O7a O    28.5275  -16.6458
            30  O6a O    27.3196  -18.7436
            31  C1a C    30.9686  -20.8345
            32  C1a C    26.1051  -15.2323
BOND        31
            1     9  11 1
            2     9  12 2
            3    10  13 1
            4    11  14 2
            5    12  15 1
            6    13  16 1
            7    13  17 2
            8    14  18 1
            9    14  19 1
            10   16  20 1
            11   16  21 1
            12   15  18 2
            13    4   5 2
            14   20  22 1
            15    5   6 1
            16   22  23 1
            17    6   7 2
            18   23  24 1
            19    7   8 1
            20   24  25 1
            21    8   3 2
            22   25  26 1
            23   26  27 1
            24   27  28 1
            25   28  29 1
            26   29   3 1
            27    3   4 1
            28   28  30 2
            29    9  10 1
            30    5  31 1
            31   27  32 1

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