Entry |
|
Name |
Josamycin (JP18/USAN/INN); Leucomycin A3; JM; Josamycin (TN) |
Formula |
C42H69NO15
|
Exact mass |
827.4667
|
Mol weight |
827.995
|
Structure |
|
Simcomp |
|
Source |
Streptomyces narbonensis [TAX: 67333]
|
Class |
Antibacterial
DG01551 Macrolide antibiotic
DG01876 16-Membered ring macrolide antibiotic
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
|
Remark |
Therapeutic category: | 6145 |
|
Efficacy |
Antibacterial, Protein biosynthesis inhibitor |
Target |
50S ribosomal subunit |
Pathway |
|
Interaction |
CYP inhibition: CYP3A4 [HSA: 1576]
|
Structure map |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
J01FA Macrolides
J01FA07 Josamycin
D01235 Josamycin (JP18/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
614 Acting mainly on gram-positive bacteria and mycoplasma
6145 Josamycins
D01235 Josamycin (JP18/USAN/INN)
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01876 16-Membered ring macrolide antibiotic
DG00604 Josamycin
D01235 Josamycin
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00604 Josamycin
D01235 Josamycin
Drug classes [BR:br08332]
Antibacterial
DG01551 Macrolide antibiotic
D01235 Josamycin
Antimicrobials [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
D01235 Josamycin (JP18/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01235 Josamycin
D01235 Josamycin tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01235
Prodrugs [br08324.html]
D01235
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01876 16-Membered ring macrolide antibiotic
DG00604 Josamycin
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00604 Josamycin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
DG00604 Josamycin
Prodrugs [br08324.html]
DG00604
|
Other DBs |
|
KCF data |
ATOM 58
1 C1y C 28.8885 -21.4172
2 C1y C 29.9965 -22.0654
3 O2a O 27.7850 -22.0654
4 C1y C 28.8885 -20.1443
5 C1y C 31.1167 -21.4172
6 N1c N 29.9965 -23.3451
7 C1y C 26.6827 -22.7024
8 O2x O 29.9965 -19.5073
9 C1a C 27.7908 -19.5073
10 C1y C 31.1167 -20.1443
11 O1a O 32.2259 -22.0654
12 C1a C 31.1054 -23.9810
13 C1a C 28.8942 -23.9810
14 C1x C 26.6827 -23.9753
15 O2x O 25.5624 -22.0654
16 O2a O 33.3513 -17.3301
17 C1z C 25.5624 -24.6234
18 C1y C 24.4544 -22.7024
19 C1y C 29.9346 -13.6690
20 C1y C 24.4544 -23.9753
21 C1a C 24.6985 -25.8456
22 O1a O 26.4614 -26.0049
23 C1a C 23.3567 -22.0654
24 C1y C 29.9291 -12.3555
25 C1y C 28.8732 -14.3344
26 O7a O 23.3567 -24.6234
27 C1x C 28.7862 -11.7129
28 C1b C 31.0257 -11.7072
29 C1y C 28.8088 -15.7160
30 O2a O 27.7584 -13.7029
31 C1y C 28.7862 -10.4232
32 C4a C 32.1404 -12.3387
33 C1x C 27.6659 -16.3073
34 C1y C 27.6601 -9.7862
35 C1a C 29.8885 -9.7806
36 O4a O 33.2427 -11.6903
37 C7x C 26.5058 -15.6647
38 C2x C 26.5578 -10.4232
39 O1a O 27.6601 -8.5141
40 O7x O 25.3471 -16.3018
41 O6a O 26.5058 -14.3851
42 C2x C 26.5578 -11.7129
43 C1y C 24.2042 -15.6071
44 C2x C 25.4262 -12.3555
45 C1x C 24.1874 -14.2540
46 C1a C 23.0782 -16.2214
47 C2x C 25.4092 -13.6520
48 C1a C 27.8181 -12.4292
49 C7a C 22.2529 -23.9972
50 C1b C 21.1550 -24.6454
51 O6a O 22.2401 -22.7296
52 C1c C 20.0512 -24.0260
53 C1a C 18.9628 -24.6722
54 C1a C 20.0357 -22.7605
55 O7a O 29.9721 -16.3864
56 C7a C 29.9733 -17.7371
57 O6a O 31.1435 -18.4114
58 C1a C 28.8042 -18.4134
BOND 60
1 10 16 1 #Up
2 14 17 1
3 15 18 1
4 19 16 1 #Down
5 17 20 1
6 17 21 1 #Down
7 17 22 1 #Up
8 18 23 1 #Down
9 19 24 1
10 19 25 1
11 20 26 1 #Up
12 24 27 1
13 24 28 1 #Down
14 25 29 1
15 25 30 1 #Down
16 27 31 1
17 28 32 1
18 29 33 1
19 31 34 1
20 31 35 1 #Down
21 32 36 2
22 33 37 1
23 34 38 1
24 34 39 1 #Down
25 37 40 1
26 37 41 2
27 38 42 2
28 40 43 1
29 42 44 1
30 43 45 1
31 43 46 1 #Down
32 44 47 2
33 8 10 1
34 18 20 1
35 45 47 1
36 30 48 1
37 1 2 1
38 26 49 1
39 1 3 1 #Down
40 49 50 1
41 1 4 1
42 49 51 2
43 2 5 1
44 50 52 1
45 2 6 1 #Up
46 7 3 1 #Up
47 4 8 1
48 4 9 1 #Up
49 5 10 1
50 5 11 1 #Down
51 52 53 1
52 6 12 1
53 52 54 1
54 29 55 1 #Down
55 6 13 1
56 55 56 1
57 7 14 1
58 56 57 2
59 7 15 1
60 56 58 1
|