KEGG   DRUG: Prilocaine hydrochloride
Entry
D01243                      Drug                                   
Name
Prilocaine hydrochloride (USP);
Propitocaine hydrochloride (JAN);
Citanest (TN)
Product
  Generic
CITANEST PLAIN (Dentsply Pharmaceutical)
Formula
C13H20N2O. HCl
Exact mass
256.1342
Mol weight
256.7716
Structure
Simcomp
Class
Cardiovascular agent
 DG01575  Calcium channel blocker
  DG01573  Calcium channel T type blocker
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01673  Amide type local anesthetic
Remark
ATC code: N01BB04
Chemical structure group: DG00803
Product (DG00803): D01243<US>
Product (mixture): D04817<JP> D04818<US>
Efficacy
Anesthetic (local)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB04 Prilocaine
      D01243  Prilocaine hydrochloride (USP) <US>
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Prilocaine
   D01243  Prilocaine hydrochloride (USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01573  Calcium channel T type blocker
    DG00803  Prilocaine
     D01243  Prilocaine hydrochloride
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01673  Amide type local anesthetic
     DG00803  Prilocaine
      D01243  Prilocaine hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN2A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN3A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN4A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN5A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN8A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN9A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN10A
     D01243  Prilocaine hydrochloride (USP) <US>
    SCN11A
     D01243  Prilocaine hydrochloride (USP) <US>
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01573  Calcium channel T type blocker
    DG00803  Prilocaine
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01673  Amide type local anesthetic
     DG00803  Prilocaine
Other DBs
CAS: 1786-81-8
PubChem: 7848306
ChEBI: 32053
LigandBox: D01243
NIKKAJI: J352.898G
KCF data

ATOM        17
            1   C8x C    16.3943  -16.8618
            2   C8x C    16.3943  -18.2644
            3   C8y C    17.6119  -18.9657
            4   C8y C    18.8224  -18.2644
            5   C8x C    18.8224  -16.8618
            6   C8x C    17.6119  -16.1605
            7   N1b N    20.0283  -18.9585
            8   C5a C    21.2396  -18.2572
            9   C1c C    22.4509  -18.9515
            10  N1b N    23.6622  -18.2503
            11  C1b C    24.8736  -18.9444
            12  C1b C    26.0849  -18.2431
            13  C1a C    27.2962  -18.9373
            14  C1a C    17.6685  -20.3682
            15  C1a C    22.4438  -20.3541
            16  O5a O    21.2325  -16.8546
            17  X   Cl   31.3854  -19.1015
BOND        16
            1     7   8 1
            2     1   2 2
            3     8   9 1
            4     2   3 1
            5     9  10 1
            6     3   4 2
            7    10  11 1
            8     4   5 1
            9    11  12 1
            10    5   6 2
            11   12  13 1
            12    6   1 1
            13    3  14 1
            14    9  15 1
            15    4   7 1
            16    8  16 2

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Ontology (4)   
   KEGG BRITE (4)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (18)   
   KEGG ORTHOLOGY (9)   
   KEGG GENES (9)   
All databases (28)   

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